G‐protein‐coupled receptor heteromers: function and ligand pharmacology

Almost all existing models for G‐protein‐coupled receptors (GPCRs) are based on the occurrence of monomers. Recent studies show that many GPCRs are dimers. Therefore for some receptors dimers and not monomers are the main species interacting with hormones/neurotransmitters/drugs. There are reasons f...

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Autors principals: Rafael Franco, Vicent Casadó, Antoni Cortés, Josefa Mallol, Francisco Ciruela, Sergi Ferré, Carme Lluı́s, Enric I. Canela
Format: Revisão
Idioma:anglès
Publicat: 2007
Accés en línia:https://doi.org/10.1038/sj.bjp.0707571
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0707571
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