Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats

Small-molecule inhibitors of prolyl hydroxylase (PHD) enzymes are a novel target for the treatment of anaemia and functional iron deficiency (FID). Other than being orally bioavailable, the differentiation of PHD inhibitors from recombinant human erythropoietin (rhEPO) has not been demonstrated.JNJ-...

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Main Authors: Terrance D. Barrett, Heather L. Palomino, Theresa I. Brondstetter, Kimon C. Kanelakis, Xiaodong Wu, Wen Yan, Katherine P Merton, Freddy Schoetens, Ying Jing, Judy Skaptason, Jingjin Gao, Da‐Thao Tran, Hariharan Venkatesan, Mark D. Rosen, Nigel P. Shankley, Michael H. Rabinowitz
格式: Artigo
语言:英语
出版: 2015
在线阅读:https://doi.org/10.1111/bph.13188
https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.13188
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