Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats

Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats

Small-molecule inhibitors of prolyl hydroxylase (PHD) enzymes are a novel target for the treatment of anaemia and functional iron deficiency (FID). Other than being orally bioavailable, the differentiation of PHD inhibitors from recombinant human erythropoietin (rhEPO) has not been demonstrated.JNJ-...

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Hlavní autoři: Terrance D. Barrett, Heather L. Palomino, Theresa I. Brondstetter, Kimon C. Kanelakis, Xiaodong Wu, Wen Yan, Katherine P Merton, Freddy Schoetens, Ying Jing, Judy Skaptason, Jingjin Gao, Da‐Thao Tran, Hariharan Venkatesan, Mark D. Rosen, Nigel P. Shankley, Michael H. Rabinowitz
Médium: Artigo
Jazyk:angličtina
Vydáno: 2015
On-line přístup:https://doi.org/10.1111/bph.13188
https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.13188
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https://doi.org/10.1111/bph.13188
https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.13188

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