The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies
OBJECTIVE Delayed-release metformin (Met DR) is formulated to deliver the drug to the lower bowel to leverage the gut-based mechanisms of metformin action with lower plasma exposure. Met DR was assessed in two studies. Study 1 compared the bioavailability of single daily doses of Met DR to currently...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Language: | English |
| Published: |
2015
|
| Online Access: | https://doi.org/10.2337/dc15-0488 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|