Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
Dampening of insulin/insulin-like growth factor-1 (IGF1) signaling results in the extension of lifespan in invertebrate as well as murine models. The impact of this evolutionarily conserved pathway on the modulation of human lifespan remains unclear. We previously identified two IGF1R mutations (Ala...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| Online-Zugang: | https://doi.org/10.1111/j.1474-9726.2011.00697.x https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2011.00697.x |
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