The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

The effects of acetaminophen and its major toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), have been investigated in hepatocytes isolated from 3-methylcholanthrene-pretreated and -untreated rats, respectively. The two compounds produced qualitatively similar changes although the quinone imi...

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Main Authors: Matthew D. Moore, Hjördis Thor, Gregory A. Moore, Sidney D. Nelson, Peter Moldéus, Sten Orrenius
Format: Artigo
Jezik:angleščina
Izdano: 1985
Online dostop:https://doi.org/10.1016/s0021-9258(17)38834-8
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Internet

https://doi.org/10.1016/s0021-9258(17)38834-8

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