The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
The effects of acetaminophen and its major toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), have been investigated in hepatocytes isolated from 3-methylcholanthrene-pretreated and -untreated rats, respectively. The two compounds produced qualitatively similar changes although the quinone imi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
1985
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| Online Access: | https://doi.org/10.1016/s0021-9258(17)38834-8 |
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