Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo

We examined the potential of ex vivo gene therapy to enhance bone repair using lentiviral vectors encoding either enhanced green fluorescent protein (EGFP) as a reporter gene or bone morphogenetic protein-2 (BMP-2) downstream of either the cytomegalovirus immediate early (CMV) promoter or the murine...

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Auteurs principaux: Osamu Sugiyama, Dong Sung An, Sam Kung, Brian T. Feeley, Seth C. Gamradt, Nancy Q. Liu, Irvin S. Y. Chen, Jay R. Lieberman
Format: Artigo
Langue:anglais
Publié: 2004
Accès en ligne:https://doi.org/10.1016/j.ymthe.2004.10.019
https://www.cell.com/article/S1525001604015114/pdf
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