Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.
Furin is a membrane-associated calcium-dependent serine endoprotease that cleaves proproteins on the carboxyl side of the consensus sequence -Arg-X-Lys/Arg-Arg-. Using site-directed mutagenesis, a variant alpha 1-antitrypsin (alpha 1-AT) was constructed which contains in its reactive site -Arg-X-X-A...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
1993
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| Accés en línia: | https://doi.org/10.1016/s0021-9258(19)74548-7 |
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