Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations

Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations

ABSTRACT Defective interfering RNAs (DI-RNAs) of the viral genome can form during infections of negative-strand RNA viruses and outgrow full-length viral genomes, thereby modulating the severity and duration of infection. Here we document the frequent de novo generation of copy-back DI-RNAs from ind...

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Bibliografski detalji
Glavni autori: Christian K. Pfaller, George Mastorakos, William E. Matchett, Xiao Ma, Charles E. Samuel, Roberto Cattaneo
Format: Artigo
Jezik:engleski
Izdano: 2015
Online pristup:https://doi.org/10.1128/jvi.01017-15
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https://doi.org/10.1128/jvi.01017-15

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