Search Results - Z. Dave Sharp

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  1. 1
    Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice

    Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice by Z. Dave Sharp, A. Bartke

    Published 2005
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  2. 2
    Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update

    Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update by Z. Dave Sharp, Randy Strong

    Published 2023
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  3. 3
    mTORC1 and p53

    mTORC1 and p53 by Paul Hasty, Z. Dave Sharp, Tyler J. Curiel, Judith Campisi

    Published 2012
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  4. 4
    Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control

    Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control by Chi‐Fen Chen, Phang‐Lang Chen, Qing Zhong, Z. Dave Sharp, Wen‐Hwa Lee

    Published 1999
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  5. 5
    Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice

    Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice by Karl A. Rodriguez, Sherry G. Dodds, Randy Strong, Verónica Galván, Z. Dave Sharp, Rochelle Buffenstein

    Published 2014
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  6. 6
    The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

    The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment by Phang‐Lang Chen, Chi‐Fen Chen, Yumay Chen, Jun Xiao, Z. Dave Sharp, Wen‐Hwa Lee

    Published 1998
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  7. 7
    The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor

    The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor by Chi‐Fen Chen, Shang Li, Yumay Chen, Phang‐Lang Chen, Z. Dave Sharp, Wen‐Hwa Lee

    Published 1996
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  8. 8
    Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage

    Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage by Shang Li, Phang‐Lang Chen, Thirugnana Subramanian, G. Chinnadurai, Gail E. Tomlinson, C. Kent Osborne, Z. Dave Sharp, Wen‐Hwa Lee

    Published 1999
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  9. 9
    Design of aging intervention studies: the NIA interventions testing program

    Design of aging intervention studies: the NIA interventions testing program by Nancy L. Nadon, Randy Strong, Richard A. Miller, James F. Nelson, Martin A. Javors, Z. Dave Sharp, Josep Maria Peralba, David E. Harrison

    Published 2008
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  10. 10
    Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

    Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs by Cheresa Calhoun, Pooja Shivshankar, Mirna Saker, Lauren Sloane, Carolina B. Livi, Z. Dave Sharp, Carlos J. Orihuela, Serge Adnot, Eric S. White, Arlan Richardson, Claude Jourdan Le Saux

    Published 2015
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  11. 11
    Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

    Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors by Carolina B. Livi, Rulon L. Hardman, Barbara A. Christy, Sherry G. Dodds, D.R. Jones, Charnae Williams, Randy Strong, Alex Bokov, Martin A. Javors, Yuji Ikeno, Gene B. Hubbard, Paul Hasty, Z. Dave Sharp

    Published 2013
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  12. 12
    Chronic <scp>mTOR</scp> inhibition in mice with rapamycin alters <scp>T</scp>,<scp> B</scp>, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice

    Chronic <scp>mTOR</scp> inhibition in mice with rapamycin alters <scp>T</scp>,<scp> B</scp>, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient... by Vincent Hurez, Vinh Dao, Aijie Liu, Srilakshmi Pandeswara, Jonathan Gelfond, Lishi Sun, Molly A. Bergman, Carlos J. Orihuela, Verónica Galván, Álvaro Padrón, Justin Drerup, Yang Liu, Paul Hasty, Z. Dave Sharp, Tyler J. Curiel

    Published 2015
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  13. 13
    Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

    Rapamycin fed late in life extends lifespan in genetically heterogeneous mice by David E. Harrison, Randy Strong, Z. Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, John E. Wilkinson, Krystyna Frenkel, Christy S. Carter, Marco Pahor, Martin A. Javors, Elizabeth Fernández, Richard A. Miller

    Published 2009
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  14. 14
    eRapa Restores a Normal Life Span in a FAP Mouse Model

    eRapa Restores a Normal Life Span in a FAP Mouse Model by Paul Hasty, Carolina B. Livi, Sherry G. Dodds, D.R. Jones, Randy Strong, Martin A. Javors, Kathleen E. Fischer, Lauren Sloane, Kruthi Murthy, Gene B. Hubbard, Lishi Sun, Vincent Hurez, Tyler J. Curiel, Z. Dave Sharp

    Published 2013
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  15. 15
    Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

    Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction by Richard A. Miller, David E. Harrison, Clinton M. Astle, Elizabeth Fernández, Kevin Flurkey, Melissa Han, Martin A. Javors, Xinna Li, Nancy L. Nadon, James F. Nelson, Scott D. Pletcher, Adam B. Salmon, Z. Dave Sharp, Sabrina Van Roekel, Lynn Winkleman, Randy Strong

    Published 2013
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  16. 16
    Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer

    Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer by Pei-Yin Hsu, Hang-Kai Hsu, Xun Lan, Liran Juan, Pearlly S. Yan, Jadwiga Labanowska, Nyla A. Heerema, Tzu‐Hung Hsiao, Yu‐Chiao Chiu, Yidong Chen, Yunlong Liu, Lang Li, Rong Li, Ian M. Thompson, Kenneth P. Nephew, Z. Dave Sharp, Nameer B. Kirma, Victor X. Jin, Tim H.‐M. Huang

    Published 2013
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  17. 17
    Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

    Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice by Richard A. Miller, David E. Harrison, Clinton M. Astle, Joseph A. Baur, Angela R. Boyd, Rafael de Cabo, Elizabeth Fernández, Kevin Flurkey, Martin A. Javors, James F. Nelson, Carlos J. Orihuela, Scott D. Pletcher, Z. Dave Sharp, David Sinclair, Joseph W. Starnes, John E. Wilkinson, Nancy L. Nadon, Randy Strong

    Published 2010
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  18. 18
    mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

    mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism by Huibin Tang, Ken Inoki, Susan V. Brooks, Hideki Okazawa, Myung Lee, Junying Wang, Michael Kim, Catherine L. Kennedy, Peter Macpherson, Xuhuai Ji, Sabrina Van Roekel, Danielle Fraga, Kun Wang, Jinguo Zhu, Yoyo Wang, Z. Dave Sharp, Richard A. Miller, Thomas A. Rando, Daniel Goldman, Kun‐Liang Guan, Joseph B. Shrager

    Published 2019
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