Canlyniadau Chwilio - Yun, Cai-Hong

Structural and Mechanistic Underpinnings of the Differential Drug Sensitivity of EGFR Mutations in Non-Small Cell Lung Cancer gan Eck, Michael J., Yun, Cai-hong

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Mechanism for activation of mutated epidermal growth factor receptors in lung cancer gan Red Brewer, Monica, Yun, Cai-Hong, Lai, Darson, Lemmon, Mark A., Eck, Michael J., Pao, William

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Structural basis of mutant-selectivity and drug-resistance related to CO-1686 gan Yan, Xiao-E, Zhu, Su-Jie, Liang, Ling, Zhao, Peng, Choi, Hwan Geun, Yun, Cai-Hong

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Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity gan Yun, Cai-Hong, Boggon, Titus J., Li, Yiqun, Woo, Michele S., Greulich, Heidi, Meyerson, Matthew, Eck, Michael J.

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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones gan Sun, Fa-Hui, Zhao, Peng, Zhang, Nan, Kong, Lu-Lu, Wong, Catherine C. L., Yun, Cai-Hong

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Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase gan Chen, Ji-Yun, Liu, Liang, Cao, Chun-Ling, Li, Mei-Jun, Tan, Kemin, Yang, Xiaohan, Yun, Cai-Hong

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EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors gan Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.

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Acetylation of 53BP1 dictates the DNA double strand break repair pathway gan Guo, Xiang, Bai, Yongtai, Zhao, Meimei, Zhou, Mei, Shen, Qinjian, Yun, Cai-Hong, Zhang, Hongquan, Zhu, Wei-Guo, Wang, Jiadong

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP gan Yun, Cai-Hong, Mengwasser, Kristen E., Toms, Angela V., Woo, Michele S., Greulich, Heidi, Wong, Kwok-Kin, Meyerson, Matthew, Eck, Michael J.

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Structure-guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology gan Zhang, Chao, Lopez, Michael S., Dar, Arvin C., LaDow, Eva, Finkbeiner, Steven, Yun, Cai-Hong, Eck, Michael J., Shokat, Kevan M.

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Structural insights into drug development strategy targeting EGFR T790M/C797S gan Zhu, Su-Jie, Zhao, Peng, Yang, Jiao, Ma, Rui, Yan, Xiao-E, Yang, Sheng-Yong, Yang, Jing-Wen, Yun, Cai-Hong

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EGF receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src gan Begley, Michael J, Yun, Cai-hong, Gewinner, Christina A, Asara, John M, Johnson, Jared L, Coyle, Anthony J, Eck, Michael J, Apostolou, Irina, Cantley, Lewis C

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Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR(T790M/C797S) Mutants gan Li, Shan, Zhang, Tao, Zhu, Su-Jie, Lei, Chong, Lai, Mengzhen, Peng, Lijie, Tong, Linjiang, Pang, Zilu, Lu, Xiaoyun, Ding, Jian, Ren, Xiaomei, Yun, Cai-Hong, Xie, Hua, Ding, Ke

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Discovery of JND3229 as a New EGFR(C797S) Mutant Inhibitor with In Vivo Monodrug Efficacy gan Lu, Xiaoyun, Zhang, Tao, Zhu, Su-Jie, Xun, Qiuju, Tong, Lingjiang, Hu, Xianglong, Li, Yan, Chan, Shingpan, Su, Yi, Sun, Yiming, Chen, Yi, Ding, Jian, Yun, Cai-Hong, Xie, Hua, Ding, Ke

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EGFR Exon 19 Insertions: A New Family of Sensitizing EGFR Mutations in Lung Adenocarcinoma gan He, Mai, Capelletti, Marzia, Nafa, Khedoudja, Yun, Cai-Hong, Arcila, Maria E., Miller, Vincent A., Ginsberg, Michelle S., Zhao, Binsheng, Kris, Mark G., Eck, Michael J., Jänne, Pasi A., Ladanyi, Marc, Oxnard, Geoffrey R.

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Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants gan Wang, Zi-Long, Gao, Hao-Meng, Wang, Shuang, Zhang, Meng, Chen, Kuan, Zhang, Ya-Qun, Wang, Hai-Dong, Han, Bo-Yun, Xu, Lu-Lu, Song, Tian-Qiao, Yun, Cai-Hong, Qiao, Xue, Ye, Min

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Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors gan De Clercq, Dries J. H., Heppner, David E., To, Ciric, Jang, Jaebong, Park, Eunyoung, Yun, Cai-Hong, Mushajiang, Mierzhati, Shin, Bo Hee, Gero, Thomas W., Scott, David A., Jänne, Pasi A., Eck, Michael J., Gray, Nathanael S.

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A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant Btk(C481S) mutation in B‐cell malignancies gan Gui, Fu, Jiang, Jie, He, Zhixiang, Li, Li, Li, Yunzhan, Deng, Zhou, Lu, Yue, Wu, Xinrui, Chen, Guyue, Su, Jingyi, Song, Siyang, Zhang, Yue‐Ming, Yun, Cai‐Hong, Huang, Xin, Weisberg, Ellen, Zhang, Jianming, Deng, Xianming

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Novel mutant-selective EGFR kinase inhibitors against EGFR T790M gan Zhou, Wenjun, Ercan, Dalia, Chen, Liang, Yun, Cai-hong, Li, Danan, Capelletti, Marzia, Cortot, Alexis B., Chirieac, Lucian, Iacob, Roxana E., Padera, Robert, Engen, John R., Wong, Kwok-Kin, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.

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Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode gan Hu, Chen, Wang, Aoli, Wu, Hong, Qi, Ziping, Li, Xixiang, Yan, Xiao-E, Chen, Cheng, Yu, Kailin, Zou, Fengming, Wang, Wenchao, Wang, Wei, Wu, Jiaxin, Liu, Juan, Wang, Beilei, Wang, Li, Ren, Tao, Zhang, Shanchun, Yun, Cai-Hong, Liu, Jing, Liu, Qingsong

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