Search Results - Yun, Cai-Hong

Structural and Mechanistic Underpinnings of the Differential Drug Sensitivity of EGFR Mutations in Non-Small Cell Lung Cancer by Eck, Michael J., Yun, Cai-hong

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Mechanism for activation of mutated epidermal growth factor receptors in lung cancer by Red Brewer, Monica, Yun, Cai-Hong, Lai, Darson, Lemmon, Mark A., Eck, Michael J., Pao, William

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Structural basis of mutant-selectivity and drug-resistance related to CO-1686 by Yan, Xiao-E, Zhu, Su-Jie, Liang, Ling, Zhao, Peng, Choi, Hwan Geun, Yun, Cai-Hong

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Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity by Yun, Cai-Hong, Boggon, Titus J., Li, Yiqun, Woo, Michele S., Greulich, Heidi, Meyerson, Matthew, Eck, Michael J.

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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones by Sun, Fa-Hui, Zhao, Peng, Zhang, Nan, Kong, Lu-Lu, Wong, Catherine C. L., Yun, Cai-Hong

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Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase by Chen, Ji-Yun, Liu, Liang, Cao, Chun-Ling, Li, Mei-Jun, Tan, Kemin, Yang, Xiaohan, Yun, Cai-Hong

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EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors by Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.

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Acetylation of 53BP1 dictates the DNA double strand break repair pathway by Guo, Xiang, Bai, Yongtai, Zhao, Meimei, Zhou, Mei, Shen, Qinjian, Yun, Cai-Hong, Zhang, Hongquan, Zhu, Wei-Guo, Wang, Jiadong

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP by Yun, Cai-Hong, Mengwasser, Kristen E., Toms, Angela V., Woo, Michele S., Greulich, Heidi, Wong, Kwok-Kin, Meyerson, Matthew, Eck, Michael J.

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Structure-guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase Technology by Zhang, Chao, Lopez, Michael S., Dar, Arvin C., LaDow, Eva, Finkbeiner, Steven, Yun, Cai-Hong, Eck, Michael J., Shokat, Kevan M.

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Structural insights into drug development strategy targeting EGFR T790M/C797S by Zhu, Su-Jie, Zhao, Peng, Yang, Jiao, Ma, Rui, Yan, Xiao-E, Yang, Sheng-Yong, Yang, Jing-Wen, Yun, Cai-Hong

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EGF receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src by Begley, Michael J, Yun, Cai-hong, Gewinner, Christina A, Asara, John M, Johnson, Jared L, Coyle, Anthony J, Eck, Michael J, Apostolou, Irina, Cantley, Lewis C

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Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR(T790M/C797S) Mutants by Li, Shan, Zhang, Tao, Zhu, Su-Jie, Lei, Chong, Lai, Mengzhen, Peng, Lijie, Tong, Linjiang, Pang, Zilu, Lu, Xiaoyun, Ding, Jian, Ren, Xiaomei, Yun, Cai-Hong, Xie, Hua, Ding, Ke

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Discovery of JND3229 as a New EGFR(C797S) Mutant Inhibitor with In Vivo Monodrug Efficacy by Lu, Xiaoyun, Zhang, Tao, Zhu, Su-Jie, Xun, Qiuju, Tong, Lingjiang, Hu, Xianglong, Li, Yan, Chan, Shingpan, Su, Yi, Sun, Yiming, Chen, Yi, Ding, Jian, Yun, Cai-Hong, Xie, Hua, Ding, Ke

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EGFR Exon 19 Insertions: A New Family of Sensitizing EGFR Mutations in Lung Adenocarcinoma by He, Mai, Capelletti, Marzia, Nafa, Khedoudja, Yun, Cai-Hong, Arcila, Maria E., Miller, Vincent A., Ginsberg, Michelle S., Zhao, Binsheng, Kris, Mark G., Eck, Michael J., Jänne, Pasi A., Ladanyi, Marc, Oxnard, Geoffrey R.

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Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants by Wang, Zi-Long, Gao, Hao-Meng, Wang, Shuang, Zhang, Meng, Chen, Kuan, Zhang, Ya-Qun, Wang, Hai-Dong, Han, Bo-Yun, Xu, Lu-Lu, Song, Tian-Qiao, Yun, Cai-Hong, Qiao, Xue, Ye, Min

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Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors by De Clercq, Dries J. H., Heppner, David E., To, Ciric, Jang, Jaebong, Park, Eunyoung, Yun, Cai-Hong, Mushajiang, Mierzhati, Shin, Bo Hee, Gero, Thomas W., Scott, David A., Jänne, Pasi A., Eck, Michael J., Gray, Nathanael S.

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A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant Btk(C481S) mutation in B‐cell malignancies by Gui, Fu, Jiang, Jie, He, Zhixiang, Li, Li, Li, Yunzhan, Deng, Zhou, Lu, Yue, Wu, Xinrui, Chen, Guyue, Su, Jingyi, Song, Siyang, Zhang, Yue‐Ming, Yun, Cai‐Hong, Huang, Xin, Weisberg, Ellen, Zhang, Jianming, Deng, Xianming

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Novel mutant-selective EGFR kinase inhibitors against EGFR T790M by Zhou, Wenjun, Ercan, Dalia, Chen, Liang, Yun, Cai-hong, Li, Danan, Capelletti, Marzia, Cortot, Alexis B., Chirieac, Lucian, Iacob, Roxana E., Padera, Robert, Engen, John R., Wong, Kwok-Kin, Eck, Michael J., Gray, Nathanael S., Jänne, Pasi A.

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Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode by Hu, Chen, Wang, Aoli, Wu, Hong, Qi, Ziping, Li, Xixiang, Yan, Xiao-E, Chen, Cheng, Yu, Kailin, Zou, Fengming, Wang, Wenchao, Wang, Wei, Wu, Jiaxin, Liu, Juan, Wang, Beilei, Wang, Li, Ren, Tao, Zhang, Shanchun, Yun, Cai-Hong, Liu, Jing, Liu, Qingsong

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