檢索結果 - Yuan‐Fang Wang
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Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV‐1 protease mutants with substrate analogs 由 Yunfeng Tie, Péter Boross, Yuan‐Fang Wang, L. Gaddis, Fengling Liu, Xianfeng Chen, József Tözsér, Robert W. Harrison, Irene T. Weber
出版 2005Artigo -
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A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro 由 Masayuki Amano, Yasuhiro Koh, Debananda Das, Jianfeng Li, Sofiya Leschenko, Yuan-Fang Wang, Péter Boross, Irene T. Weber, Arun K. Ghosh, Hiroaki Mitsuya
出版 2007Artigo -
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Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evalua... 由 Arun K. Ghosh, Sofiya Leshchenko-Yashchuk, David D. Anderson, Abigail Baldridge, Marcus W. Noetzel, Heather B. Miller, Yunfeng Tie, Yuan-Fang Wang, Yasuhiro Koh, Irene T. Weber, Hiroaki Mitsuya
出版 2009Artigo -
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Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants 由 Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Heather L. Osswald, Cuthbert D. Martyr, Manabu Aoki, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Haydar Bulut, Debananda Das, Irene T. Weber, Hiroaki Mitsuya
出版 2017Artigo -
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Novel <i>bis</i> -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency... 由 Yasuhiro Koh, Hirotomo Nakata, Kenji Maeda, Hiromi Ogata, Geoffrey Bilcer, Thippeswamy Devasamudram, John Kincaid, Péter Boross, Yuan-Fang Wang, Yunfeng Tie, Patra Volarath, L. Gaddis, Robert W. Harrison, Irene T. Weber, Arun K. Ghosh, Hiroaki Mitsuya
出版 2003Artigo
相關主題
Biochemistry
Biology
Enzyme
Protease
Chemistry
HIV-1 protease
Virology
Antiretroviral therapy
Human immunodeficiency virus (HIV)
Protease inhibitor (pharmacology)
Stereochemistry
Viral load
Gene
Medicine
Mutant
Amprenavir
Crystallography
Enzyme inhibitor
In vitro
Indinavir
Organic chemistry
Receptor
Sida
Viral disease
Active site
Combinatorial chemistry
Ecology
Immunology
Internal medicine
Ligand (biochemistry)