Výsledky vyhledávání - Yuan‐Fang Wang
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Kinetic, Stability, and Structural Changes in High-resolution Crystal Structures of HIV-1 Protease with Drug-resistant Mutations L24I, I50V, and G73S Autor Fengling Liu, Péter Boross, Yuan-Fang Wang, József Tözsér, John M. Louis, Robert W. Harrison, Irene T. Weber
Vydáno 2005Artigo -
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Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV‐1 protease mutants with substrate analogs Autor Yunfeng Tie, Péter Boross, Yuan‐Fang Wang, L. Gaddis, Fengling Liu, Xianfeng Chen, József Tözsér, Robert W. Harrison, Irene T. Weber
Vydáno 2005Artigo -
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Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M Autor Andrey Kovalevsky, Yunfeng Tie, Fengling Liu, Péter Boross, Yuan‐Fang Wang, Sofiya Leshchenko, Arun K. Ghosh, Robert W. Harrison, Irene T. Weber
Vydáno 2006Artigo -
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A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro Autor Masayuki Amano, Yasuhiro Koh, Debananda Das, Jianfeng Li, Sofiya Leschenko, Yuan-Fang Wang, Péter Boross, Irene T. Weber, Arun K. Ghosh, Hiroaki Mitsuya
Vydáno 2007Artigo -
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Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evalua... Autor Arun K. Ghosh, Sofiya Leshchenko-Yashchuk, David D. Anderson, Abigail Baldridge, Marcus W. Noetzel, Heather B. Miller, Yunfeng Tie, Yuan-Fang Wang, Yasuhiro Koh, Irene T. Weber, Hiroaki Mitsuya
Vydáno 2009Artigo -
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Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants Autor Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Heather L. Osswald, Cuthbert D. Martyr, Manabu Aoki, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Haydar Bulut, Debananda Das, Irene T. Weber, Hiroaki Mitsuya
Vydáno 2017Artigo -
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Novel <i>bis</i> -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency... Autor Yasuhiro Koh, Hirotomo Nakata, Kenji Maeda, Hiromi Ogata, Geoffrey Bilcer, Thippeswamy Devasamudram, John Kincaid, Péter Boross, Yuan-Fang Wang, Yunfeng Tie, Patra Volarath, L. Gaddis, Robert W. Harrison, Irene T. Weber, Arun K. Ghosh, Hiroaki Mitsuya
Vydáno 2003Artigo
Vyhledávací nástroje:
Související témata
Biochemistry
Biology
Enzyme
Protease
Chemistry
HIV-1 protease
Virology
Antiretroviral therapy
Human immunodeficiency virus (HIV)
Protease inhibitor (pharmacology)
Stereochemistry
Viral load
Gene
Medicine
Mutant
Amprenavir
Crystallography
Enzyme inhibitor
In vitro
Indinavir
Organic chemistry
Receptor
Sida
Viral disease
Active site
Combinatorial chemistry
Ecology
Immunology
Internal medicine
Ligand (biochemistry)