Výsledky vyhledávání - Yosuke Osawa

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  1. 1
    Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs

    Wnt/β-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs Autor Koji Nishikawa, Yosuke Osawa, Kiminori Kimura

    Vydáno 2018
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    Revisão
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  2. 2
    Tumor Necrosis Factor-α Promotes Cholestasis-Induced Liver Fibrosis in the Mouse through Tissue Inhibitor of Metalloproteinase-1 Production in Hepatic Stellate Cells

    Tumor Necrosis Factor-α Promotes Cholestasis-Induced Liver Fibrosis in the Mouse through Tissue Inhibitor of Metalloproteinase-1 Production in Hepatic Stellate Cells Autor Yosuke Osawa, Masato Hoshi, Ichiro Yasuda, Toshiji Saibara, Hisataka Moriwaki, Osamu Kozawa

    Vydáno 2013
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    Artigo
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  3. 3
    Anandamide induces necrosis in primary hepatic stellate cells

    Anandamide induces necrosis in primary hepatic stellate cells Autor Sören Siegmund, Hiroshi Uchinami, Yosuke Osawa, David A. Brenner, Robert F. Schwabe

    Vydáno 2005
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    Artigo
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  4. 4
    The Forkhead Transcription Factor FoxO1 Regulates Proliferation and Transdifferentiation of Hepatic Stellate Cells

    The Forkhead Transcription Factor FoxO1 Regulates Proliferation and Transdifferentiation of Hepatic Stellate Cells Autor Masayuki Adachi, Yosuke Osawa, Hiroshi Uchinami, Tadahiro Kitamura, Domenico Accili, David A. Brenner

    Vydáno 2007
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    Artigo
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  5. 5
    Antiapoptotic Effect of c-Jun N-terminal Kinase-1 through Mcl-1 Stabilization in TNF-Induced Hepatocyte Apoptosis

    Antiapoptotic Effect of c-Jun N-terminal Kinase-1 through Mcl-1 Stabilization in TNF-Induced Hepatocyte Apoptosis Autor Yuzo Kodama, Kojiro Taura, Kouichi Miura, Bernd Schnabl, Yosuke Osawa, David A. Brenner

    Vydáno 2009
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    Artigo
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  6. 6
    Fatty Acid Amide Hydrolase Determines Anandamide-induced Cell Death in the Liver

    Fatty Acid Amide Hydrolase Determines Anandamide-induced Cell Death in the Liver Autor Sören Siegmund, Ekihiro Seki, Yosuke Osawa, Hiroshi Uchinami, Benjamin F. Cravatt, Robert F. Schwabe

    Vydáno 2006
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  7. 7
    Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α

    Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α Autor Yosuke Osawa, Hiroshi Uchinami, Jacek Bielawski, Robert F. Schwabe, Yusuf A. Hannun, David A. Brenner

    Vydáno 2005
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  8. 8
    TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes

    TNF-α-Induced Sphingosine 1-Phosphate Inhibits Apoptosis Through a Phosphatidylinositol 3-Kinase/Akt Pathway in Human Hepatocytes Autor Yosuke Osawa, Yoshiko Banno, Masahito Nagaki, David A. Brenner, Taku Naiki, Yoshinori Nozawa, Shigeru Nakashima, Hisataka Moriwaki

    Vydáno 2001
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    Artigo
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  9. 9
    Tumor Necrosis Factor Alpha-Induced Interleukin-8 Production via NF-κB and Phosphatidylinositol 3-Kinase/Akt Pathways Inhibits Cell Apoptosis in Human Hepatocytes

    Tumor Necrosis Factor Alpha-Induced Interleukin-8 Production via NF-κB and Phosphatidylinositol 3-Kinase/Akt Pathways Inhibits Cell Apoptosis in Human Hepatocytes Autor Yosuke Osawa, Masahito Nagaki, Yoshiko Banno, David A. Brenner, Takahiko Asano, Yoshinori Nozawa, Hisataka Moriwaki, Shigeru Nakashima

    Vydáno 2002
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    Artigo
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  10. 10
    Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

    Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice Autor Yosuke Osawa, Keisuke Oboki, Jun Imamura, Ekumi Kojika, Yukiko Hayashi, Tsunekazu Hishima, Toshiji Saibara, Futoshi Shibasaki, Michinori Kohara, Kiminori Kimura

    Vydáno 2015
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  11. 11
    Seasonal changes in spermatogenesis and testicular steroidogenesis in the male black bear Ursus americanus

    Seasonal changes in spermatogenesis and testicular steroidogenesis in the male black bear Ursus americanus Autor Toshio Tsubota, Lesley A. Skalla, Hiroaki Nitta, Yosuke Osawa, J. Ian Mason, P. G. Meiers, R.A. Nelson, J. M. Bahr

    Vydáno 1997
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  12. 12
    Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation

    Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation Autor Satoshi Nemoto, Mitsuhiro Nakamura, Yosuke Osawa, Saki Kono, Yoshinori Itoh, Yukio Okano, Takashi Murate, Akira Hara, Hiroshi Ueda, Yoshinori Nozawa, Yoshiko Banno

    Vydáno 2009
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  13. 13
    <scp>l</scp>-Tryptophan–Kynurenine Pathway Metabolites Regulate Type I IFNs of Acute Viral Myocarditis in Mice

    <scp>l</scp>-Tryptophan–Kynurenine Pathway Metabolites Regulate Type I IFNs of Acute Viral Myocarditis in Mice Autor Masato Hoshi, Keishi Matsumoto, Hiroyasu Ito, Hirofumi Ohtaki, Yuko Arioka, Yosuke Osawa, Yasuko Yamamoto, Hidetoshi Matsunami, Akira Hara, Mitsuru Seishima, Kuniaki Saito

    Vydáno 2012
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  14. 14
    The Absence of IDO Upregulates Type I IFN Production, Resulting in Suppression of Viral Replication in the Retrovirus-Infected Mouse

    The Absence of IDO Upregulates Type I IFN Production, Resulting in Suppression of Viral Replication in the Retrovirus-Infected Mouse Autor Masato Hoshi, Kuniaki Saito, Akira Hara, Ayako Taguchi, Hirofumi Ohtaki, Ryo Tanaka, Hidetsugu Fujigaki, Yosuke Osawa, Masao Takemura, Hidetoshi Matsunami, Hiroyasu Ito, Mitsuru Seishima

    Vydáno 2010
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  15. 15
    l-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin

    l-Tryptophan-mediated Enhancement of Susceptibility to Nonalcoholic Fatty Liver Disease Is Dependent on the Mammalian Target of Rapamycin Autor Yosuke Osawa, Hiromitsu Kanamori, Ekihiro Seki, Masato Hoshi, Hirofumi Ohtaki, Yoichi Yasuda, Hiroyasu Ito, Atsushi Suetsugu, Masahito Nagaki, Hisataka Moriwaki, Kuniaki Saito, Mitsuru Seishima

    Vydáno 2011
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  16. 16
    Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model

    Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model Autor Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama‐Kohara, Tsunekazu Hishima, Soichi Kojima, Kiminori Kimura, Michinori Kohara

    Vydáno 2017
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  17. 17
    Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial

    Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Singl... Autor Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara, Masashi Mizokami

    Vydáno 2017
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