Resultats de la cerca - Xavier Langlois

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  1. 1
    Pharmacokinetic–pharmacodynamic modelling of fluvoxamine 5‐HT transporter occupancy in rat frontal cortex

    Pharmacokinetic–pharmacodynamic modelling of fluvoxamine 5‐HT transporter occupancy in rat frontal cortex per Marian Geldof, Jan Freijer, Ludy van Beijsterveldt, Xavier Langlois, Meindert Danhof

    Publicat 2008
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  2. 2
    Combined α2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat

    Combined α2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat per Monica M. Marcus, Kent Jardemark, Marie-Louise Wadenberg, Xavier Langlois, P. Hertel, Torgny H. Svensson

    Publicat 2005
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  3. 3
    Preclinical evaluation of the antipsychotic potential of the mGlu2‐positive allosteric modulator JNJ‐40411813

    Preclinical evaluation of the antipsychotic potential of the mGlu2‐positive allosteric modulator JNJ‐40411813 per Hilde Lavreysen, Xavier Langlois, Luc Ver Donck, José María Cid Nuñez, Stefan Pype, Robert Lütjens, Anton A. H. P. Megens

    Publicat 2015
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  4. 4
    Pyrido[4,3-<i>e</i>][1,2,4]triazolo[4,3-<i>a</i>]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors

    Pyrido[4,3-<i>e</i>][1,2,4]triazolo[4,3-<i>a</i>]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors per Frederik Rombouts, Gary Tresadern, Peter Buijnsters, Xavier Langlois, Fulgencio Tovar, Thomas Steinbrecher, Greet Vanhoof, Marijke Somers, José-Ignacio Andrés, Andrés A. Trabanco

    Publicat 2015
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  5. 5
    Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice

    Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice per Steven Biesmans, J Adriaan Bouwknecht, Luc Ver Donck, Xavier Langlois, Paul D. Acton, Patrick De Haes, Nima Davoodi, Theo Meert, Niels Hellings, Rony Nuydens

    Publicat 2015
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  6. 6
    Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor

    Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor per Hilde Lavreysen, A. Ahnaou, Wilhelmus Drinkenburg, Xavier Langlois, Claire Mackie, Stefan Pype, Robert Lütjens, Emmanuel Le Poul, Andrés A. Trabanco, José María Cid Nuñez

    Publicat 2014
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  7. 7
    Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement

    Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement per Peter Buijnsters, Meri De Angelis, Xavier Langlois, Frederik Rombouts, Wendy E. Sanderson, Gary Tresadern, Alison Ritchie, Andrés A. Trabanco, Greet Vanhoof, Yves Van Roosbroeck, José-Ignacio Andrés

    Publicat 2014
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  8. 8
    Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule

    Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule per Eckhard Bender, Arjan Buist, Mirek Jurzak, Xavier Langlois, Geert Baggerman, Peter Verhasselt, Martine Ercken, Hongqing Guo, Cindy Wintmolders, Ilse Van den Wyngaert, Irma Van Oers, Liliane Schoofs, Walter Luyten

    Publicat 2002
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  9. 9
    Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

    Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice per Steven Biesmans, Theo Meert, J Adriaan Bouwknecht, Paul D. Acton, Nima Davoodi, Patrick De Haes, Jacobine Kuijlaars, Xavier Langlois, Liam J. R. Matthews, Luc Ver Donck, Niels Hellings, Rony Nuydens

    Publicat 2013
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  10. 10
    Preclinical Evaluation of <sup>18</sup>F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain

    Preclinical Evaluation of <sup>18</sup>F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain per Sofie Celen, Michel Koole, Meri De Angelis, I. SANNEN, Satish K. Chitneni, Jesús Alcázar, Stefanie Dedeurwaerdere, Dieder Moechars, Mark E. Schmidt, Alfons Verbruggen, Xavier Langlois, Koen Van Laere, José Ignacio Andrés, Guy Bormans

    Publicat 2010
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  11. 11
    Preclinical Evaluation of<sup>18</sup>F-JNJ64349311, a Novel PET Tracer for Tau Imaging

    Preclinical Evaluation of<sup>18</sup>F-JNJ64349311, a Novel PET Tracer for Tau Imaging per Lieven Declercq, Frederik Rombouts, Michel Koole, Katleen Fierens, Jonas Mariën, Xavier Langlois, José Ignacio Andrés, Mark E. Schmidt, Gregor J. Macdonald, Diederik Moechars, Wim Vanduffel, Thomas Tousseyn, Rik Vandenberghe, Koen Van Laere, Alfons Verbruggen, Guy Bormans

    Publicat 2017
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  12. 12
    Acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H<sub>3</sub> antagonist

    Acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H<sub>3</sub> antagonist per Ann Barbier, Craig W. Berridge, Christine Dugovic, Aaron D. Laposky, Sandy J. Wilson, Jamin D. Boggs, Leah Aluisio, Brian Lord, Curt Mazur, Cindy M. Pudiak, Xavier Langlois, Wei Xiao, Richard L. Apodaca, Nicholas I. Carruthers, Timothy W. Lovenberg

    Publicat 2004
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  13. 13
    Common mouse models of tauopathy reflect early but not late human disease

    Common mouse models of tauopathy reflect early but not late human disease per Kathrin Wenger, Arthur Viodé, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony W. Bannon, Rui B. Chang, Theresa R. Connors, Derek H. Oakley, Bernhard Y. Renard, Juri Rappsilber, Bradley T. Hyman, Hanno Steen, Judith A. Steen

    Publicat 2023
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  14. 14
    Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

    Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates per Dieter Ory, Sofie Celen, Rik Gijsbers, Chris Van den Haute, Andrey Postnov, Michel Koole, Caroline Vandeputte, José-Ignacio Andrés, Jesús Alcázar, Meri De Angelis, Xavier Langlois, Anindya Bhattacharya, Mark E. Schmidt, Michael A. Letavic, Wim Vanduffel, Koen Van Laere, Alfons Verbruggen, Zeger Debyser, Guy Bormans

    Publicat 2016
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  15. 15
    Discovery of VU0409551/JNJ-46778212: An mGlu<sub>5</sub> Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia

    Discovery of VU0409551/JNJ-46778212: An mGlu<sub>5</sub> Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia per Susana Conde-Ceide, Carlos M. Martínez‐Viturro, Jesús Alcázar, Pedro M. García-Barrantes, Hilde Lavreysen, Claire Mackie, Paige N. Vinson, Jerri M. Rook, Thomas M. Bridges, J. Scott Daniels, Anton A. H. P. Megens, Xavier Langlois, Wilhelmus Drinkenburg, A. Ahnaou, Colleen M. Niswender, Carrie K. Jones, Gregor J. Macdonald, Thomas Steckler, P. Jeffrey Conn, Shaun R. Stauffer, José M. Bartolomé-Nebreda, Craig W. Lindsley

    Publicat 2015
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  16. 16
    Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau

    Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau per Astrid Wachter, Maya E. Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily J. McGlame, Timothy Pastika, Joseph A. Tamm, Nandini Romanul, Kiran Yanamandra, Rachel E. Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Y. Grinberg, Methasit Jaisa-aad, Li Huan, Matthew P. Frosch, Markus P. Kummer, Sudeshna Das, Tammy Dellovade, Eric Karran, Xavier Langlois, Janina S. Ried, Alberto Serrano‐Pozo, Robert V. Talanian, Knut Biber, Bradley T. Hyman

    Publicat 2024
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