Rezultati - Vivanco, Igor

Inhibitors in AKTion: ATP-competitive vs allosteric od Lazaro, Glorianne, Kostaras, Eleftherios, Vivanco, Igor

Polni tekst Polni tekst Polni tekst

Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients od Stein, Shayna, Zhao, Rui, Haeno, Hiroshi, Vivanco, Igor, Michor, Franziska

Polni tekst Polni tekst Polni tekst

Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine od Coleman, Niamh, Moyers, Justin T, Harbery, Alice, Vivanco, Igor, Yap, Timothy A

Polni tekst Polni tekst Polni tekst

A kinase-independent function of AKT promotes cancer cell survival od Vivanco, Igor, Chen, Zhi C, Tanos, Barbara, Oldrini, Barbara, Hsieh, Wan-Ying, Yannuzzi, Nicolas, Campos, Carl, Mellinghoff, Ingo K

Polni tekst Polni tekst Polni tekst

IQGAP1 controls tight junction formation through differential regulation of claudin recruitment od Tanos, Barbara E., Perez Bay, Andres E., Salvarezza, Susana, Vivanco, Igor, Mellinghoff, Ingo, Osman, Mahasin, Sacks, David B., Rodriguez-Boulan, Enrique

Polni tekst Polni tekst Polni tekst

Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency od Peng, Li, Wu, Ting-Ting, Tchieu, Jason H., Feng, Jun, Brown, Helen J., Feng, Jiaying, Li, Xudong, Qi, Jing, Deng, Hongyu, Vivanco, Igor, Mellinghoff, Ingo K., Jamieson, Christina, Sun, Ren

Polni tekst Polni tekst Polni tekst

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death od Graham, Nicholas A, Tahmasian, Martik, Kohli, Bitika, Komisopoulou, Evangelia, Zhu, Maggie, Vivanco, Igor, Teitell, Michael A, Wu, Hong, Ribas, Antoni, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Graeber, Thomas G

Polni tekst Polni tekst Polni tekst

STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors od Hubert, Rene S., Vivanco, Igor, Chen, Emily, Rastegar, Shiva, Leong, Kahan, Mitchell, Steve C., Madraswala, Rashida, Zhou, Yanhong, Kuo, James, Raitano, Arthur B., Jakobovits, Aya, Saffran, Douglas C., Afar, Daniel E. H.

Polni tekst Polni tekst

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer od Regales, Lucia, Gong, Yixuan, Shen, Ronglai, de Stanchina, Elisa, Vivanco, Igor, Goel, Aviva, Koutcher, Jason A., Spassova, Maria, Ouerfelli, Ouathek, Mellinghoff, Ingo K., Zakowski, Maureen F., Politi, Katerina A., Pao, William

Polni tekst Polni tekst Polni tekst

DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF od Gutierrez-Prat, Nuria, Zuberer, Hedwig L, Mangano, Luca, Karimaddini, Zahra, Wolf, Luise, Tyanova, Stefka, Wellinger, Lisa C, Marbach, Daniel, Griesser, Vera, Pettazzoni, Piergiorgio, Bischoff, James R, Rohle, Daniel, Palladino, Chiara, Vivanco, Igor

Polni tekst Polni tekst Polni tekst

A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity od Kostaras, Eleftherios, Kaserer, Teresa, Lazaro, Glorianne, Heuss, Sara Farrah, Hussain, Aasia, Casado, Pedro, Hayes, Angela, Yandim, Cihangir, Palaskas, Nicolaos, Yu, Yi, Schwartz, Brian, Raynaud, Florence, Chung, Yuen-Li, Cutillas, Pedro R., Vivanco, Igor

Polni tekst Polni tekst Polni tekst

Preliminary evidence of antitumour activity of Ipatasertib (Ipat) and Atezolizumab (ATZ) in glioblastoma patients (pts) with PTEN loss from the Phase 1 Ice-CAP trial (NCT03673787) od Tiu, Crescens, Welsh, Liam, Jones, Timothy, Zachariou, Anna, Prout, Toby, Turner, Alison, Daly, Rob, Tunariu, Nina, Riisnaes, Ruth, Gurel, Bora, Crespo, Mateus, Carreira, Suzanne, Vivanco, Igor, Jenkins, Ben, Yap, Christina, Minchom, Anna, Banerji, Udai, deBono, Johann, Lopez, Juanita

Polni tekst Polni tekst

SCIDOT-08. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM (CBTDDC) od Rahman, Ruman, Campbell, Emma, Brem, Henry, Pearl, Monica, Green, Jordan, Janowski, Miroslaw, Walczak, Piotr, Tyler, Betty, Warren, Katherine, Singleton, Will, Mullen, Alexander, Boyd, Marie, Veal, Gareth, Hargrave, Darren, van Vuurden, Dannis, Powell, Steven, Battaglia, Giuseppe, Vivanco, Igor, Al-Jamal, Khuloud, Walker, David

Polni tekst Polni tekst

EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer od Oldrini, Barbara, Hsieh, Wan-Ying, Erdjument-Bromage, Hediye, Codega, Paolo, Carro, Maria Stella, Curiel-García, Alvaro, Campos, Carl, Pourmaleki, Maryam, Grommes, Christian, Vivanco, Igor, Rohle, Daniel, Bielski, Craig M., Taylor, Barry S., Hollmann, Travis J., Rosenblum, Marc, Tempst, Paul, Blenis, John, Squatrito, Massimo, Mellinghoff, Ingo K.

Polni tekst Polni tekst Polni tekst

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies od Veeriah, Selvaraju, Taylor, Barry S, Meng, Shasha, Fang, Fang, Yilmaz, Emrullah, Vivanco, Igor, Janakiraman, Manickam, Schultz, Nikolaus, Hanrahan, Aphrothiti J, Pao, William, Ladanyi, Marc, Sander, Chris, Heguy, Adriana, Holland, Eric C, Paty, Philip B, Mischel, Paul S, Liau, Linda, Cloughesy, Timothy F, Mellinghoff, Ingo K, Solit, David B, Chan, Timothy A

Polni tekst Polni tekst Polni tekst

RBTT-06. TESSA JOWELL BRAIN MATRIX STUDY: A BRITISH FEASIBILITY STUDY OF MOLECULAR STRATIFICATION AND TARGETED THERAPY TO OPTIMIZE THE CLINICAL MANAGEMENT OF PATIENTS WITH GLIOMA od Watts, Colin, Apps, John, Ansorg, Olaf, Savage, Josh, Fox, Richard, Chalmers, Anthony, Short, Susan C, Thompson, Gerard, Waldman, Adam, Capper, David, Hargrave, Darren, Brennan, Paul, Smith, Stuart, Ashkan, Keyoumars, Wykes, Victoria, Kurian, Kathreena, Jamal-Hanjani, Mariam, Swanton, Charles, Buckle, Peter, Bulbeck, Helen, Stead, Lucy F, Vivanco, Igor, Bowden, Sarah

Polni tekst Polni tekst

The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation od Vivanco, Igor, Rohle, Daniel, Versele, Matthias, Iwanami, Akio, Kuga, Daisuke, Oldrini, Barbara, Tanaka, Kazuhiro, Dang, Julie, Kubek, Sara, Palaskas, Nicolaos, Hsueh, Teli, Evans, Michael, Mulholland, David, Wolle, Daniel, Rajasekaran, Sigrid, Rajasekaran, Ayyappan, Liau, Linda M., Cloughesy, Timothy F., Dikic, Ivan, Brennan, Cameron, Wu, Hong, Mischel, Paul S., Perera, Timothy, Mellinghoff, Ingo K.

Polni tekst Polni tekst Polni tekst

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers od Veeriah, Selvaraju, Brennan, Cameron, Meng, Shasha, Singh, Bhuvanesh, Fagin, James A., Solit, David B., Paty, Philip B., Rohle, Dan, Vivanco, Igor, Chmielecki, Juliann, Pao, William, Ladanyi, Marc, Gerald, William L., Liau, Linda, Cloughesy, Timothy C., Mischel, Paul S., Sander, Chris, Taylor, Barry, Schultz, Nikolaus, Major, John, Heguy, Adriana, Fang, Fang, Mellinghoff, Ingo K., Chan, Timothy A.

Polni tekst Polni tekst Polni tekst

EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers od Smyth, Elizabeth C, Vlachogiannis, Georgios, Hedayat, Somaieh, Harbery, Alice, Hulkki-Wilson, Sanna, Salati, Massimiliano, Kouvelakis, Kyriakos, Fernandez-Mateos, Javier, Cresswell, George D, Fontana, Elisa, Seidlitz, Therese, Peckitt, Clare, Hahne, Jens C, Lampis, Andrea, Begum, Ruwaida, Watkins, David, Rao, Sheela, Starling, Naureen, Waddell, Tom, Okines, Alicia, Crosby, Tom, Mansoor, Was, Wadsley, Jonathan, Middleton, Gary, Fassan, Matteo, Wotherspoon, Andrew, Braconi, Chiara, Chau, Ian, Vivanco, Igor, Sottoriva, Andrea, Stange, Daniel E, Cunningham, David, Valeri, Nicola

Polni tekst Polni tekst Polni tekst

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma od Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, Vivanco, Igor, Lee, Jeffrey C., Huang, Julie H., Alexander, Sethu, Du, Jinyan, Kau, Tweeny, Thomas, Roman K., Shah, Kinjal, Soto, Horacio, Perner, Sven, Prensner, John, Debiasi, Ralph M., Demichelis, Francesca, Hatton, Charlie, Rubin, Mark A., Garraway, Levi A., Nelson, Stan F., Liau, Linda, Mischel, Paul S., Cloughesy, Tim F., Meyerson, Matthew, Golub, Todd A., Lander, Eric S., Mellinghoff, Ingo K., Sellers, William R.

Polni tekst Polni tekst Polni tekst