Søgeresultater - Vivanco, Igor

Inhibitors in AKTion: ATP-competitive vs allosteric af Lazaro, Glorianne, Kostaras, Eleftherios, Vivanco, Igor

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Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients af Stein, Shayna, Zhao, Rui, Haeno, Hiroshi, Vivanco, Igor, Michor, Franziska

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Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine af Coleman, Niamh, Moyers, Justin T, Harbery, Alice, Vivanco, Igor, Yap, Timothy A

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A kinase-independent function of AKT promotes cancer cell survival af Vivanco, Igor, Chen, Zhi C, Tanos, Barbara, Oldrini, Barbara, Hsieh, Wan-Ying, Yannuzzi, Nicolas, Campos, Carl, Mellinghoff, Ingo K

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IQGAP1 controls tight junction formation through differential regulation of claudin recruitment af Tanos, Barbara E., Perez Bay, Andres E., Salvarezza, Susana, Vivanco, Igor, Mellinghoff, Ingo, Osman, Mahasin, Sacks, David B., Rodriguez-Boulan, Enrique

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Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency af Peng, Li, Wu, Ting-Ting, Tchieu, Jason H., Feng, Jun, Brown, Helen J., Feng, Jiaying, Li, Xudong, Qi, Jing, Deng, Hongyu, Vivanco, Igor, Mellinghoff, Ingo K., Jamieson, Christina, Sun, Ren

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Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death af Graham, Nicholas A, Tahmasian, Martik, Kohli, Bitika, Komisopoulou, Evangelia, Zhu, Maggie, Vivanco, Igor, Teitell, Michael A, Wu, Hong, Ribas, Antoni, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Graeber, Thomas G

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STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors af Hubert, Rene S., Vivanco, Igor, Chen, Emily, Rastegar, Shiva, Leong, Kahan, Mitchell, Steve C., Madraswala, Rashida, Zhou, Yanhong, Kuo, James, Raitano, Arthur B., Jakobovits, Aya, Saffran, Douglas C., Afar, Daniel E. H.

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Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer af Regales, Lucia, Gong, Yixuan, Shen, Ronglai, de Stanchina, Elisa, Vivanco, Igor, Goel, Aviva, Koutcher, Jason A., Spassova, Maria, Ouerfelli, Ouathek, Mellinghoff, Ingo K., Zakowski, Maureen F., Politi, Katerina A., Pao, William

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DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF af Gutierrez-Prat, Nuria, Zuberer, Hedwig L, Mangano, Luca, Karimaddini, Zahra, Wolf, Luise, Tyanova, Stefka, Wellinger, Lisa C, Marbach, Daniel, Griesser, Vera, Pettazzoni, Piergiorgio, Bischoff, James R, Rohle, Daniel, Palladino, Chiara, Vivanco, Igor

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A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity af Kostaras, Eleftherios, Kaserer, Teresa, Lazaro, Glorianne, Heuss, Sara Farrah, Hussain, Aasia, Casado, Pedro, Hayes, Angela, Yandim, Cihangir, Palaskas, Nicolaos, Yu, Yi, Schwartz, Brian, Raynaud, Florence, Chung, Yuen-Li, Cutillas, Pedro R., Vivanco, Igor

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Preliminary evidence of antitumour activity of Ipatasertib (Ipat) and Atezolizumab (ATZ) in glioblastoma patients (pts) with PTEN loss from the Phase 1 Ice-CAP trial (NCT03673787) af Tiu, Crescens, Welsh, Liam, Jones, Timothy, Zachariou, Anna, Prout, Toby, Turner, Alison, Daly, Rob, Tunariu, Nina, Riisnaes, Ruth, Gurel, Bora, Crespo, Mateus, Carreira, Suzanne, Vivanco, Igor, Jenkins, Ben, Yap, Christina, Minchom, Anna, Banerji, Udai, deBono, Johann, Lopez, Juanita

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SCIDOT-08. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM (CBTDDC) af Rahman, Ruman, Campbell, Emma, Brem, Henry, Pearl, Monica, Green, Jordan, Janowski, Miroslaw, Walczak, Piotr, Tyler, Betty, Warren, Katherine, Singleton, Will, Mullen, Alexander, Boyd, Marie, Veal, Gareth, Hargrave, Darren, van Vuurden, Dannis, Powell, Steven, Battaglia, Giuseppe, Vivanco, Igor, Al-Jamal, Khuloud, Walker, David

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EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer af Oldrini, Barbara, Hsieh, Wan-Ying, Erdjument-Bromage, Hediye, Codega, Paolo, Carro, Maria Stella, Curiel-García, Alvaro, Campos, Carl, Pourmaleki, Maryam, Grommes, Christian, Vivanco, Igor, Rohle, Daniel, Bielski, Craig M., Taylor, Barry S., Hollmann, Travis J., Rosenblum, Marc, Tempst, Paul, Blenis, John, Squatrito, Massimo, Mellinghoff, Ingo K.

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Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies af Veeriah, Selvaraju, Taylor, Barry S, Meng, Shasha, Fang, Fang, Yilmaz, Emrullah, Vivanco, Igor, Janakiraman, Manickam, Schultz, Nikolaus, Hanrahan, Aphrothiti J, Pao, William, Ladanyi, Marc, Sander, Chris, Heguy, Adriana, Holland, Eric C, Paty, Philip B, Mischel, Paul S, Liau, Linda, Cloughesy, Timothy F, Mellinghoff, Ingo K, Solit, David B, Chan, Timothy A

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RBTT-06. TESSA JOWELL BRAIN MATRIX STUDY: A BRITISH FEASIBILITY STUDY OF MOLECULAR STRATIFICATION AND TARGETED THERAPY TO OPTIMIZE THE CLINICAL MANAGEMENT OF PATIENTS WITH GLIOMA af Watts, Colin, Apps, John, Ansorg, Olaf, Savage, Josh, Fox, Richard, Chalmers, Anthony, Short, Susan C, Thompson, Gerard, Waldman, Adam, Capper, David, Hargrave, Darren, Brennan, Paul, Smith, Stuart, Ashkan, Keyoumars, Wykes, Victoria, Kurian, Kathreena, Jamal-Hanjani, Mariam, Swanton, Charles, Buckle, Peter, Bulbeck, Helen, Stead, Lucy F, Vivanco, Igor, Bowden, Sarah

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The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation af Vivanco, Igor, Rohle, Daniel, Versele, Matthias, Iwanami, Akio, Kuga, Daisuke, Oldrini, Barbara, Tanaka, Kazuhiro, Dang, Julie, Kubek, Sara, Palaskas, Nicolaos, Hsueh, Teli, Evans, Michael, Mulholland, David, Wolle, Daniel, Rajasekaran, Sigrid, Rajasekaran, Ayyappan, Liau, Linda M., Cloughesy, Timothy F., Dikic, Ivan, Brennan, Cameron, Wu, Hong, Mischel, Paul S., Perera, Timothy, Mellinghoff, Ingo K.

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The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers af Veeriah, Selvaraju, Brennan, Cameron, Meng, Shasha, Singh, Bhuvanesh, Fagin, James A., Solit, David B., Paty, Philip B., Rohle, Dan, Vivanco, Igor, Chmielecki, Juliann, Pao, William, Ladanyi, Marc, Gerald, William L., Liau, Linda, Cloughesy, Timothy C., Mischel, Paul S., Sander, Chris, Taylor, Barry, Schultz, Nikolaus, Major, John, Heguy, Adriana, Fang, Fang, Mellinghoff, Ingo K., Chan, Timothy A.

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EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers af Smyth, Elizabeth C, Vlachogiannis, Georgios, Hedayat, Somaieh, Harbery, Alice, Hulkki-Wilson, Sanna, Salati, Massimiliano, Kouvelakis, Kyriakos, Fernandez-Mateos, Javier, Cresswell, George D, Fontana, Elisa, Seidlitz, Therese, Peckitt, Clare, Hahne, Jens C, Lampis, Andrea, Begum, Ruwaida, Watkins, David, Rao, Sheela, Starling, Naureen, Waddell, Tom, Okines, Alicia, Crosby, Tom, Mansoor, Was, Wadsley, Jonathan, Middleton, Gary, Fassan, Matteo, Wotherspoon, Andrew, Braconi, Chiara, Chau, Ian, Vivanco, Igor, Sottoriva, Andrea, Stange, Daniel E, Cunningham, David, Valeri, Nicola

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Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma af Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, Vivanco, Igor, Lee, Jeffrey C., Huang, Julie H., Alexander, Sethu, Du, Jinyan, Kau, Tweeny, Thomas, Roman K., Shah, Kinjal, Soto, Horacio, Perner, Sven, Prensner, John, Debiasi, Ralph M., Demichelis, Francesca, Hatton, Charlie, Rubin, Mark A., Garraway, Levi A., Nelson, Stan F., Liau, Linda, Mischel, Paul S., Cloughesy, Tim F., Meyerson, Matthew, Golub, Todd A., Lander, Eric S., Mellinghoff, Ingo K., Sellers, William R.

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