Resultats de la cerca - Vivanco, Igor

Inhibitors in AKTion: ATP-competitive vs allosteric per Lazaro, Glorianne, Kostaras, Eleftherios, Vivanco, Igor

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Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients per Stein, Shayna, Zhao, Rui, Haeno, Hiroshi, Vivanco, Igor, Michor, Franziska

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Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine per Coleman, Niamh, Moyers, Justin T, Harbery, Alice, Vivanco, Igor, Yap, Timothy A

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A kinase-independent function of AKT promotes cancer cell survival per Vivanco, Igor, Chen, Zhi C, Tanos, Barbara, Oldrini, Barbara, Hsieh, Wan-Ying, Yannuzzi, Nicolas, Campos, Carl, Mellinghoff, Ingo K

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IQGAP1 controls tight junction formation through differential regulation of claudin recruitment per Tanos, Barbara E., Perez Bay, Andres E., Salvarezza, Susana, Vivanco, Igor, Mellinghoff, Ingo, Osman, Mahasin, Sacks, David B., Rodriguez-Boulan, Enrique

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Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency per Peng, Li, Wu, Ting-Ting, Tchieu, Jason H., Feng, Jun, Brown, Helen J., Feng, Jiaying, Li, Xudong, Qi, Jing, Deng, Hongyu, Vivanco, Igor, Mellinghoff, Ingo K., Jamieson, Christina, Sun, Ren

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Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death per Graham, Nicholas A, Tahmasian, Martik, Kohli, Bitika, Komisopoulou, Evangelia, Zhu, Maggie, Vivanco, Igor, Teitell, Michael A, Wu, Hong, Ribas, Antoni, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Graeber, Thomas G

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STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors per Hubert, Rene S., Vivanco, Igor, Chen, Emily, Rastegar, Shiva, Leong, Kahan, Mitchell, Steve C., Madraswala, Rashida, Zhou, Yanhong, Kuo, James, Raitano, Arthur B., Jakobovits, Aya, Saffran, Douglas C., Afar, Daniel E. H.

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Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer per Regales, Lucia, Gong, Yixuan, Shen, Ronglai, de Stanchina, Elisa, Vivanco, Igor, Goel, Aviva, Koutcher, Jason A., Spassova, Maria, Ouerfelli, Ouathek, Mellinghoff, Ingo K., Zakowski, Maureen F., Politi, Katerina A., Pao, William

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DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF per Gutierrez-Prat, Nuria, Zuberer, Hedwig L, Mangano, Luca, Karimaddini, Zahra, Wolf, Luise, Tyanova, Stefka, Wellinger, Lisa C, Marbach, Daniel, Griesser, Vera, Pettazzoni, Piergiorgio, Bischoff, James R, Rohle, Daniel, Palladino, Chiara, Vivanco, Igor

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A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity per Kostaras, Eleftherios, Kaserer, Teresa, Lazaro, Glorianne, Heuss, Sara Farrah, Hussain, Aasia, Casado, Pedro, Hayes, Angela, Yandim, Cihangir, Palaskas, Nicolaos, Yu, Yi, Schwartz, Brian, Raynaud, Florence, Chung, Yuen-Li, Cutillas, Pedro R., Vivanco, Igor

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Preliminary evidence of antitumour activity of Ipatasertib (Ipat) and Atezolizumab (ATZ) in glioblastoma patients (pts) with PTEN loss from the Phase 1 Ice-CAP trial (NCT03673787) per Tiu, Crescens, Welsh, Liam, Jones, Timothy, Zachariou, Anna, Prout, Toby, Turner, Alison, Daly, Rob, Tunariu, Nina, Riisnaes, Ruth, Gurel, Bora, Crespo, Mateus, Carreira, Suzanne, Vivanco, Igor, Jenkins, Ben, Yap, Christina, Minchom, Anna, Banerji, Udai, deBono, Johann, Lopez, Juanita

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SCIDOT-08. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM (CBTDDC) per Rahman, Ruman, Campbell, Emma, Brem, Henry, Pearl, Monica, Green, Jordan, Janowski, Miroslaw, Walczak, Piotr, Tyler, Betty, Warren, Katherine, Singleton, Will, Mullen, Alexander, Boyd, Marie, Veal, Gareth, Hargrave, Darren, van Vuurden, Dannis, Powell, Steven, Battaglia, Giuseppe, Vivanco, Igor, Al-Jamal, Khuloud, Walker, David

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EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer per Oldrini, Barbara, Hsieh, Wan-Ying, Erdjument-Bromage, Hediye, Codega, Paolo, Carro, Maria Stella, Curiel-García, Alvaro, Campos, Carl, Pourmaleki, Maryam, Grommes, Christian, Vivanco, Igor, Rohle, Daniel, Bielski, Craig M., Taylor, Barry S., Hollmann, Travis J., Rosenblum, Marc, Tempst, Paul, Blenis, John, Squatrito, Massimo, Mellinghoff, Ingo K.

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Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies per Veeriah, Selvaraju, Taylor, Barry S, Meng, Shasha, Fang, Fang, Yilmaz, Emrullah, Vivanco, Igor, Janakiraman, Manickam, Schultz, Nikolaus, Hanrahan, Aphrothiti J, Pao, William, Ladanyi, Marc, Sander, Chris, Heguy, Adriana, Holland, Eric C, Paty, Philip B, Mischel, Paul S, Liau, Linda, Cloughesy, Timothy F, Mellinghoff, Ingo K, Solit, David B, Chan, Timothy A

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RBTT-06. TESSA JOWELL BRAIN MATRIX STUDY: A BRITISH FEASIBILITY STUDY OF MOLECULAR STRATIFICATION AND TARGETED THERAPY TO OPTIMIZE THE CLINICAL MANAGEMENT OF PATIENTS WITH GLIOMA per Watts, Colin, Apps, John, Ansorg, Olaf, Savage, Josh, Fox, Richard, Chalmers, Anthony, Short, Susan C, Thompson, Gerard, Waldman, Adam, Capper, David, Hargrave, Darren, Brennan, Paul, Smith, Stuart, Ashkan, Keyoumars, Wykes, Victoria, Kurian, Kathreena, Jamal-Hanjani, Mariam, Swanton, Charles, Buckle, Peter, Bulbeck, Helen, Stead, Lucy F, Vivanco, Igor, Bowden, Sarah

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The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation per Vivanco, Igor, Rohle, Daniel, Versele, Matthias, Iwanami, Akio, Kuga, Daisuke, Oldrini, Barbara, Tanaka, Kazuhiro, Dang, Julie, Kubek, Sara, Palaskas, Nicolaos, Hsueh, Teli, Evans, Michael, Mulholland, David, Wolle, Daniel, Rajasekaran, Sigrid, Rajasekaran, Ayyappan, Liau, Linda M., Cloughesy, Timothy F., Dikic, Ivan, Brennan, Cameron, Wu, Hong, Mischel, Paul S., Perera, Timothy, Mellinghoff, Ingo K.

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The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers per Veeriah, Selvaraju, Brennan, Cameron, Meng, Shasha, Singh, Bhuvanesh, Fagin, James A., Solit, David B., Paty, Philip B., Rohle, Dan, Vivanco, Igor, Chmielecki, Juliann, Pao, William, Ladanyi, Marc, Gerald, William L., Liau, Linda, Cloughesy, Timothy C., Mischel, Paul S., Sander, Chris, Taylor, Barry, Schultz, Nikolaus, Major, John, Heguy, Adriana, Fang, Fang, Mellinghoff, Ingo K., Chan, Timothy A.

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EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers per Smyth, Elizabeth C, Vlachogiannis, Georgios, Hedayat, Somaieh, Harbery, Alice, Hulkki-Wilson, Sanna, Salati, Massimiliano, Kouvelakis, Kyriakos, Fernandez-Mateos, Javier, Cresswell, George D, Fontana, Elisa, Seidlitz, Therese, Peckitt, Clare, Hahne, Jens C, Lampis, Andrea, Begum, Ruwaida, Watkins, David, Rao, Sheela, Starling, Naureen, Waddell, Tom, Okines, Alicia, Crosby, Tom, Mansoor, Was, Wadsley, Jonathan, Middleton, Gary, Fassan, Matteo, Wotherspoon, Andrew, Braconi, Chiara, Chau, Ian, Vivanco, Igor, Sottoriva, Andrea, Stange, Daniel E, Cunningham, David, Valeri, Nicola

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Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma per Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, Vivanco, Igor, Lee, Jeffrey C., Huang, Julie H., Alexander, Sethu, Du, Jinyan, Kau, Tweeny, Thomas, Roman K., Shah, Kinjal, Soto, Horacio, Perner, Sven, Prensner, John, Debiasi, Ralph M., Demichelis, Francesca, Hatton, Charlie, Rubin, Mark A., Garraway, Levi A., Nelson, Stan F., Liau, Linda, Mischel, Paul S., Cloughesy, Tim F., Meyerson, Matthew, Golub, Todd A., Lander, Eric S., Mellinghoff, Ingo K., Sellers, William R.

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