Canlyniadau Chwilio - Tree, Timothy

Reconstruction of a pathway of antigen processing and class II MHC peptide capture gan Moss, Catherine X, Tree, Timothy I, Watts, Colin

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Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it? gan Hull, Caroline M., Peakman, Mark, Tree, Timothy I. M.

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HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides gan Ellis, Richard J, Varela-Calvino, Ruben, Tree, Timothy I M, Peakman, Mark

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Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression gan Tree, Timothy I.M., Lawson, Jennifer, Edwards, Hannah, Skowera, Ania, Arif, Sefina, Roep, Bart O., Peakman, Mark

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health gan Arif, Sefina, Tree, Timothy I., Astill, Thomas P., Tremble, Jennifer M., Bishop, Amanda J., Dayan, Colin M., Roep, Bart O., Peakman, Mark

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The Expression of Active CD11b Monocytes in Blood and Disease Progression in Amyotrophic Lateral Sclerosis gan Yildiz, Ozlem, Schroth, Johannes, Lombardi, Vittoria, Pucino, Valentina, Bobeva, Yoana, Yip, Ping Kei, Schmierer, Klaus, Mauro, Claudio, Tree, Timothy, Henson, Sian Mari, Malaspina, Andrea

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Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances gan Ahmed, Simi, Cerosaletti, Karen, James, Eddie, Long, S. Alice, Mannering, Stuart, Speake, Cate, Nakayama, Maki, Tree, Timothy, Roep, Bart O., Herold, Kevan C., Brusko, Todd M.

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INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes gan Dunger, David B., Bruggraber, Sylvaine F. A., Mander, Adrian P., Marcovecchio, M. Loredana, Tree, Timothy, Chmura, Piotr Jaroslaw, Knip, Mikael, Schulte, Anke M., Mathieu, Chantal

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Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner gan Carty, Fiona, Corbett, Jennifer M., Cunha, João Paulo M. C. M., Reading, James L., Tree, Timothy I. M., Ting, Anthony E., Stubblefield, Samantha R., English, Karen

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Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects gan Arif, Sefina, Pujol-Autonell, Irma, Kamra, Yogesh, Williams, Evangelia, Yusuf, Norkhairin, Domingo-Vila, Clara, Shahrabi, Yasaman, Pollock, Emily, Khatri, Leena, Peakman, Mark, Tree, Timothy, Lorenc, Anna

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Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture gan Allen, Jennifer S., Pang, Karl, Skowera, Ania, Ellis, Richard, Rackham, Chloe, Lozanoska-Ochser, Biliana, Tree, Timothy, Leslie, R. David G., Tremble, Jennifer M., Dayan, Colin M., Peakman, Mark

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GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells gan Arif, Sefina, Gomez-Tourino, Iria, Kamra, Yogesh, Pujol-Autonell, Irma, Hanton, Emily, Tree, Timothy, Melandri, Daisy, Hull, Caroline, Wherrett, Diane K., Beam, Craig, Roep, Bart O., Lorenc, Anna, Peakman, Mark

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Type 1 Diabetes-associated IL2RAvariationlowers IL-2 signaling and contributes to diminished CD4(+)CD25(+) regulatory T-cell function gan Garg, Garima, Tyler, Jennifer R, Yang, Jennie H M, Cutler, Antony J, Downes, Kate, Pekalski, Marcin, Bell, Louise, Nutland, Sarah, Peakman, Mark, Todd, John A, Wicker, Linda S, Tree, Timothy I M

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Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes gan Liu, Yuk-Fun, Powrie, Jake, Arif, Sefina, Yang, Jennie H.M., Williams, Evangelia, Khatri, Leena, Joshi, Mamta, Lhuillier, Loic, Fountoulakis, Nikolaos, Smith, Emma, Beam, Craig, Lorenc, Anna, Peakman, Mark, Tree, Timothy

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Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis gan Lu, Ching-Hua, Allen, Kezia, Oei, Felicia, Leoni, Emanuela, Kuhle, Jens, Tree, Timothy, Fratta, Pietro, Sharma, Nikhil, Sidle, Katie, Howard, Robin, Orrell, Richard, Fish, Mark, Greensmith, Linda, Pearce, Neil, Gallo, Valentina, Malaspina, Andrea

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Augmented Expansion of Treg Cells From Healthy and Autoimmune Subjects via Adult Progenitor Cell Co-Culture gan Reading, James L., Roobrouck, Valerie D., Hull, Caroline M., Becker, Pablo Daniel, Beyens, Jelle, Valentin-Torres, Alice, Boardman, Dominic, Lamperti, Estefania Nova, Stubblefield, Samantha, Lombardi, Giovanna, Deans, Robert, Ting, Anthony E., Tree, Timothy

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Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death gan Arif, Sefina, Moore, Fabrice, Marks, Katherine, Bouckenooghe, Thomas, Dayan, Colin M., Planas, Raquel, Vives-Pi, Marta, Powrie, Jake, Tree, Timothy, Marchetti, Piero, Huang, Guo Cai, Gurzov, Esteban N., Pujol-Borrell, Ricardo, Eizirik, Decio L., Peakman, Mark

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IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors gan Whitehouse, Gavin, Gray, Elizabeth, Mastoridis, Sotiris, Merritt, Elliot, Kodela, Elisavet, Yang, Jennie H. M., Danger, Richard, Mairal, Marta, Christakoudi, Sofia, Lozano, Juan J., Macdougall, Iain C., Tree, Timothy I. M., Sanchez-Fueyo, Alberto, Martinez-Llordella, Marc

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Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2 gan Reading, James L, Vaes, Bart, Hull, Caroline, Sabbah, Shereen, Hayday, Thomas, Wang, Nancy S, DiPiero, Anthony, Lehman, Nicholas A, Taggart, Jen M, Carty, Fiona, English, Karen, Pinxteren, Jef, Deans, Robert, Ting, Anthony E, Tree, Timothy I M

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Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes gan Yang, Jennie H.M., Cutler, Antony J., Ferreira, Ricardo C., Reading, James L., Cooper, Nicholas J., Wallace, Chris, Clarke, Pamela, Smyth, Deborah J., Boyce, Christopher S., Gao, Guo-Jian, Todd, John A., Wicker, Linda S., Tree, Timothy I.M.

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