Search Results - Tracy Zimmermann

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  1. 1
    Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

    Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate by Tracy Zimmermann, Verena Karsten, Amy Chan, Joseph Chiesa, Malcolm Boyce, Brian R. Bettencourt, Renta Hutabarat, Saraswathy V. Nochur, Akshay Vaishnaw, Jared Gollob

    Published 2017
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  2. 2
    Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

    Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression by Jennifer L. S. Willoughby, Amy Chan, Alfica Sehgal, James S. Butler, Jayaprakash K. Nair, Tim Racie, Svetlana Shulga‐Morskaya, Tuyen Nguyen, Kun Qian, Kristina Yucius, Klaus Charissé, Theo J.C. van Berkel, Muthiah Manoharan, Kallanthottathil G. Rajeev, Martin A. Maier, Vasant Jadhav, Tracy Zimmermann

    Published 2017
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  3. 3
    Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

    Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis by James S. Butler, Amy Chan, Susete Costelha, Shannon Fishman, Jennifer L. S. Willoughby, Todd Borland, Stuart Milstein, Donald J. Foster, Paula Gonçalves, Qingmin Chen, June Qin, Brian R. Bettencourt, Dinah W.Y. Sah, Rene Alvarez, Kallanthottathil G. Rajeev, Muthiah Manoharan, Kevin Fitzgerald, Rachel Meyers, Saraswathy V. Nochur, Maria João Saraiva, Tracy Zimmermann

    Published 2016
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  4. 4
    Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

    Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates by Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Xuemei Zhang, Minggeng Gao, Ju Liu, Ramesh Indrakanti, Sally Schofield, Philip Kretschmer, Christopher R. Brown, Swati Gupta, Jennifer L. S. Willoughby, Julie A. Boshar, Vasant Jadhav, Klaus Charissé, Tracy Zimmermann, Kevin Fitzgerald, Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Renta Hutabarat, Martin A. Maier

    Published 2017
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  5. 5
    A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    A combinatorial library of lipid-like materials for delivery of RNAi therapeutics by Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg, Elizaveta S. Leshchiner, Valentina Busini, Naushad Hossain, Sergio Bacallado, David N. Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin de Fougerolles, J. Robert Dorkin, K. N. Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir V. Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G. Rajeev, Dinah W.Y. Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans‐Peter Vornlocher, Tracy Zimmermann, Róbert Langer, Daniel G. Anderson

    Published 2008
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  6. 6
    Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates by Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N. Anderson, Timothy Racie, Birgit Bramlage, Akin Akinc, David Butler, Klaus Charissé, Robert Dorkin, Yupeng Fan, Christina Gamba‐Vitalo, Philipp Hadwiger, Muthusamy Jayaraman, Matthias John, K. N. Jayaprakash, Martin A. Maier, Lubomir V. Nechev, Kallanthottathil G. Rajeev, Timothy Read, Ingo Röhl, Jürgen Soutschek, Pamela Tan, Jamie Wong, Gang Wang, Tracy Zimmermann, Antonin de Fougerolles, Hans-Peter Vornlocher, Róbert Langer, Daniel G. Anderson, Muthiah Manoharan, Victor Koteliansky, Jay D. Horton, Kevin Fitzgerald

    Published 2008
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  7. 7
    Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates

    Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates by Maja M. Janas, Ivan Zlatev, Ju Liu, Yongfeng Jiang, Scott Barros, Jessica E. Sutherland, Wendell Davis, Jingxuan Liu, Christopher R. Brown, Xiumin Liu, Mark K. Schlegel, Lauren P. Blair, Xuemei Zhang, Biplab Das, Chris Tran, Krishna Aluri, Jing Li, Saket Agarwal, Ramesh Indrakanti, Klaus Charissé, Jayaprakash K. Nair, Shigeo Matsuda, Kallanthottathil G. Rajeev, Tracy Zimmermann, Laura Sepp‐Lorenzino, Yuanxin Xu, Akin Akinc, Kevin Fitzgerald, Akshay Vaishnaw, Peter F. Smith, Muthiah Manoharan, Vasant Jadhav, Jing‐Tao Wu, Martin A. Maier

    Published 2019
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