检索结果 - Tim Ahfeldt

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  1. 1
    Modeling the complex genetic architectures of brain disease

    Modeling the complex genetic architectures of brain disease 由 Michael B. Fernando, Tim Ahfeldt, Kristen Brennand

    出版 2020
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  2. 2
    A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells

    A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells 由 Nimet Maherali, Tim Ahfeldt, Alessandra Rigamonti, Jochen Utikal, Chad A. Cowan, Konrad Hochedlinger

    出版 2008
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  3. 3
    Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells

    Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells 由 Sarah Eminli, Adlen Foudi, Matthias Stadtfeld, Nimet Maherali, Tim Ahfeldt, Gustavo Mostoslavsky, Hanno Hock, Konrad Hochedlinger

    出版 2009
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  4. 4
    Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy

    Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy 由 Alban Ordureau, Felix Kraus, Jiuchun Zhang, Heeseon An, Sookhee Park, Tim Ahfeldt, João A. Paulo, J. Wade Harper

    出版 2021
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  5. 5
    Disease-Specific Induced Pluripotent Stem Cells

    Disease-Specific Induced Pluripotent Stem Cells 由 In-Hyun Park, Natasha Arora, Hongguang Huo, Nimet Maherali, Tim Ahfeldt, Akiko Shimamura, M. William Lensch, Chad A. Cowan, Konrad Hochedlinger, George Q. Daley

    出版 2008
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  6. 6
    Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

    Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs 由 Hongmei Mou, Rui Zhao, Richard I. Sherwood, Tim Ahfeldt, Allen Lapey, John Wain, Leonard Sicilian, Konstantin I. Izvolsky, Frank H. Lau, Yan V. Sun, Chad A. Cowan, Jayaraj Rajagopal

    出版 2012
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  7. 7
    Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics

    Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics 由 Alban Ordureau, João A. Paulo, Wei Zhang, Tim Ahfeldt, Jiuchun Zhang, Erin F. Cohn, Zhonggang Hou, Jin‐Mi Heo, Lee L. Rubin, Sachdev S. Sidhu, Steven P. Gygi, J. Wade Harper

    出版 2018
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  8. 8
    Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

    Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity 由 Ana Catarina Ferreira, B Hemmer, Sarah M. Philippi, Alejandro Grau‐Perales, Jacob L. Rosenstadt, Hanxiao Liu, Jeffrey Zhu, Tatyana Kareva, Tim Ahfeldt, Merina Varghese, Patrick R. Hof, Joseph M. Castellano

    出版 2023
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  9. 9
    Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model

    Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model 由 Gustavo Morrone Parfitt, Elena Coccia, Camille Goldman, Kristen Whitney, Ricardo Reyes, Lily Sarrafha, Ki Hong Nam, Soha Sohail, Drew R. Jones, John F. Crary, Alban Ordureau, Joel Blanchard, Tim Ahfeldt

    出版 2024
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  10. 10
    Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

    Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons 由 Tim Ahfeldt, Alban Ordureau, Christina Bell, Lily Sarrafha, Chicheng Sun, Silvia Piccinotti, Tobias Graß, Gustavo Morrone Parfitt, João A. Paulo, Fumiki Yanagawa, Takayuki Uozumi, Yasujiro Kiyota, J. Wade Harper, Lee L. Rubin

    出版 2020
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  11. 11
    Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

    Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA 由 Luigi Warren, Philip D. Manos, Tim Ahfeldt, Yuin‐Han Loh, Hu Li, Frank H. Lau, Wataru Ebina, Pankaj Kumar Mandal, Zachary D. Smith, Alexander Meissner, George Q. Daley, Andrew S. Brack, James J. Collins, Chad A. Cowan, Thorsten M. Schlaeger, Derrick J. Rossi

    出版 2010
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  12. 12
    Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease

    Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease 由 Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, M H Liang, Lap Ho, Kurt Farrell, Kristin G. Beaumont, Robert Sebra, Claudia De Sanctis, John F. Crary, Tim Ahfeldt, Joel Blanchard, Drew Neavin, Joseph E. Powell, David A. Davis, Xiaoyan Sun, Bin Zhang, Zhenyu Yue

    出版 2024
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  13. 13
    A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

    A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides 由 Kimberly C. Paul, Richard C. Krolewski, Edinson Lucumi Moreno, Jack Blank, Kristina M. Holton, Tim Ahfeldt, Melissa Furlong, Yu Yu, Myles Cockburn, Laura Thompson, Alexander Kreymerman, Elisabeth M. Ricci-Blair, Yu Jun Li, Heer B. Patel, Richard Lee, Jeff M. Bronstein, Lee L. Rubin, Vikram Khurana, Beate Ritz

    出版 2023
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  14. 14
    Programming human pluripotent stem cells into white and brown adipocytes

    Programming human pluripotent stem cells into white and brown adipocytes 由 Tim Ahfeldt, Robert T. Schinzel, Youn‐Kyoung Lee, David G. Hendrickson, Adam Kaplan, David H. Lum, Raymond Camahort, Fang Xia, Jennifer Shay, Eugene P. Rhee, Clary B. Clish, Rahul C. Deo, Tony S. Shen, Frank H. Lau, Alicia Cowley, Greg Mowrer, Heba Al-Siddiqi, Matthias Nahrendorf, Yan V. Sun, Robert E. Gerszten, John L. Rinn, Chad A. Cowan

    出版 2012
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  15. 15
    A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

    A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models 由 Qiurong Ding, Youn‐Kyoung Lee, Esperance Schaefer, Derek Peters, Adrian Veres, Kevin J. Kim, Nicolas Kuperwasser, Daniel Motola, Torsten Meißner, William T. Hendriks, Marta Trevisan, Rajat Gupta, Annie Moisan, Eric Banks, Max Friesen, Robert T. Schinzel, Fang Xia, Alexander Tang, Yulei Xia, Emmanuel Figueroa, Amy Wann, Tim Ahfeldt, Laurence Dahéron, Feng Zhang, Lee L. Rubin, Lee F. Peng, Raymond T. Chung, Kiran Musunuru, Chad A. Cowan

    出版 2012
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  16. 16
    Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

    Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities 由 Jon M. Madison, Fangjian Zhou, Aparna Nigam, Ali Hussain, Douglas Barker, Ralda Nehme, Karlijn van der Ven, Jonathan Y. Hsu, Pavlina Wolf, Morgan Fleishman, C O'Dushlaine, Samuel A. Rose, Kimberly Chambert, Frank H. Lau, Tim Ahfeldt, Erroll H. Rueckert, Steven D. Sheridan, Daniel M. Fass, James Nemesh, Thomas E. Mullen, Laurence Dahéron, Steven A. McCarroll, Pamela Sklar, Roy H. Perlis, Stephen J. Haggarty

    出版 2015
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  17. 17
    From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

    From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus 由 Yan V. Sun, Alanna Strong, Maria Frank-Kamenetsky, Noemi E Lee, Tim Ahfeldt, Katherine V. Sachs, Xiaoyu Li, Hui Li, Nicolas Kuperwasser, Vera M. Ruda, James P. Pirruccello, Brian Muchmore, Ludmila Prokunina‐Olsson, Jennifer L. Hall, Eric E. Schadt, Carlos R. Morales, Sissel Lund‐Katz, Michael C. Phillips, Jamie Wong, William Cantley, Timothy Racie, Kenechi G. Ejebe, Marju Orho‐Melander, Olle Melander, Victor Koteliansky, Kevin Fitzgerald, Ronald M. Krauss, Chad A. Cowan, Sekar Kathiresan, Daniel J. Rader

    出版 2010
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  18. 18
    A reference human induced pluripotent stem cell line for large-scale collaborative studies

    A reference human induced pluripotent stem cell line for large-scale collaborative studies 由 Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kumar Kanaujiya, Jizhong Zou, David P. Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, Constance Medura, Christopher Tompkins, Stephen H. Hughes, Marianita Santiana, Faraz Faghri, Mike A. Nalls, Dan Vitale, Shannon Ballard, Yue Qi, Daniel M. Ramos, Kailyn Anderson, Julia T. Stadler, Priyanka Narayan, Jason Papademetriou, Luke Reilly, Matthew P. Nelson, Sanya Aggarwal, Leah U. Rosen, Peter Kirwan, Venkat Pisupati, Steven L. Coon, Sonja W. Scholz, Theresa Priebe, Miriam Öttl, Jian Dong, Marieke Meijer, Lara J.M. Janssen, Vanessa S. Lourenco, Rik van der Kant, Dennis Crusius, Dominik Paquet, Ana‐Caroline Raulin, Guojun Bu, Aaron Held, Brian J. Wainger, Rebecca Gabriele, Jackie M. Casey, Selina Wray, Dad Abu-Bonsrah, Clare L. Parish, Melinda S. Beccari, Don W. Cleveland, Emmy Li, Indigo V.L. Rose, Martin Kampmann, Carles Calatayud, Patrik Verstreken, Laurin Heinrich, Max Y. Chen, Birgitt Schüle, Dan Dou, Erika L.F. Holzbaur, Maria Clara Zanellati, Richa Basundra, Mohanish Deshmukh, Sarah Cohen, Richa Khanna, Malavika Raman, Zachary S. Nevin, Madeline Matia, Jonas Van Lent, Vincent Timmerman, Bruce R. Conklin, Katherine Johnson Chase, Ke Zhang, Salome Funes, Daryl A. Bosco, Lena Erlebach, Marc Welzer, Deborah Kronenberg‐Versteeg, Guochang Lyu, Ernest Arenas, Elena Coccia, Lily Sarrafha, Tim Ahfeldt, John C. Marioni, William C. Skarnes, Mark Cookson, Michael E. Ward, Florian T. Merkle

    出版 2022
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