Søgeresultater - Tilman Schlothauer

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  1. 1
    MecA, an adaptor protein necessary for ClpC chaperone activity

    MecA, an adaptor protein necessary for ClpC chaperone activity af Tilman Schlothauer, Axel Mogk, David A. Dougan, Bernd Bukau, Kürşad Turgay

    Udgivet 2003
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  2. 2
    Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants

    Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants af Tetyana Dashivets, Marco Thomann, Petra Rueger, Alexander Knaupp, Johannes Büchner, Tilman Schlothauer

    Udgivet 2015
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  3. 3
    Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

    Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry af Pernille Foged Jensen, Vincent Larraillet, Tilman Schlothauer, Hubert Kettenberger, Maximiliane Hilger, Kasper D. Rand

    Udgivet 2014
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  4. 4
    Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies

    Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies af Tetyana Dashivets, Jan Olaf Stracke, Stefan Dengl, Alexander Knaupp, Jan Pollmann, Johannes Büchner, Tilman Schlothauer

    Udgivet 2016
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  5. 5
    In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity

    In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity af Marco Thomann, Tilman Schlothauer, Tetyana Dashivets, Sebastian Malik, Cécile Avenal, Patrick Bulau, Petra Rüger, Dietmar Reusch

    Udgivet 2015
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  6. 6
    A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life

    A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life af Pernille Foged Jensen, Angela Schoch, Vincent Larraillet, Maximiliane Hilger, Tilman Schlothauer, Thomas Emrich, Kasper D. Rand

    Udgivet 2017
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  7. 7
    Adaptor protein controlled oligomerization activates the AAA+ protein ClpC

    Adaptor protein controlled oligomerization activates the AAA+ protein ClpC af Janine Kirstein, Tilman Schlothauer, David A. Dougan, Hauke Lilie, Gilbert Tischendorf, Axel Mogk, Bernd Bukau, Kürşad Turgay

    Udgivet 2006
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  8. 8
    Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS

    Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS af Miriam Hensel, Rebecca Steurer, Juergen Fichtl, Carsten Elger, Frank Wedekind, A. Petzold, Tilman Schlothauer, Michael Mølhøj, Dietmar Reusch, Patrick Bulau

    Udgivet 2011
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  9. 9
    Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

    Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions af Tilman Schlothauer, Sylvia Herter, Claudia Ferrara, Sandra Grau-Richards, Virginie Steinhart, Christian Spick, Manfred Kubbies, Christian Klein, Pablo Umaña, Ekkehard Mössner

    Udgivet 2016
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  10. 10
    Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

    Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies af Tilman Schlothauer, Petra Rueger, Jan Olaf Stracke, Hubert Hertenberger, Felix Fingas, Lothar Kling, Thomas Emrich, Georg Drabner, Stefan Seeber, Johannes Auer, Stefan Koch, Apollon Papadimitriou

    Udgivet 2013
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  11. 11
    Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures

    Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures af Katharina Diepold, Katrin Bomans, Michael Wiedmann, Boris Zimmermann, A. Petzold, Tilman Schlothauer, Robert Mueller, Bernd Moritz, Jan Olaf Stracke, Michael Mølhøj, Dietmar Reusch, Patrick Bulau

    Udgivet 2012
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  12. 12
    A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

    A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies af Jan Olaf Stracke, Thomas Emrich, Petra Rueger, Tilman Schlothauer, Lothar Kling, Alexander Knaupp, Hubert Hertenberger, Andreas Wolfert, Christian Spick, Wilma Lau, Georg Drabner, Ulrike Reiff, Hans Koll, Apollon Papadimitriou

    Udgivet 2014
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  13. 13
    Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions

    Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions af Ingrid Schmid, Lea Bonnington, Monika Gerl, Katrin Bomans, Anna Louisa Thaller, Katharina Wagner, Tilman Schlothauer, Roberto Falkenstein, Boris Zimmermann, Jürgen Kopitz, Max Hasmann, Frieder Bauss, Markus Haberger, Dietmar Reusch, Patrick Bulau

    Udgivet 2018
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  14. 14
    Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

    Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life af Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem‐Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens A. A. Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen

    Udgivet 2022
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  15. 15
    Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

    Assessment of chemical modifications of sites in the CDRs of recombinant antibodies af Markus Haberger, Katrin Bomans, Katharina Diepold, Michaela Hook, Jana Gassner, Tilman Schlothauer, Adrian Zwick, Christian Spick, Jochen Felix Kepert, Brigitte Hienz, Michael Wiedmann, Hermann Beck, Philipp Metzger, Michael Mølhøj, Constanze Knoblich, Ulla Grauschopf, Dietmar Reusch, Patrick Bulau

    Udgivet 2014
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  16. 16
    Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans

    Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans af Hans Peter Grimm, Vanessa Schumacher, Martin Schäfer, Sabine Imhof-Jung, Per‐Ola Freskgård, Kevin Brady, Carsten Hofmann, Petra Rüger, Tilman Schlothauer, Ulrich Göpfert, Maximilian J. Hartl, Sylvia Rottach, Adrian Zwick, Shanon Seger, Rachel Neff, Jens Niewoehner, Niels Janssen

    Udgivet 2023
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  17. 17
    A human endothelial cell-based recycling assay for screening of FcRn targeted molecules

    A human endothelial cell-based recycling assay for screening of FcRn targeted molecules af Algirdas Grevys, Jeannette Nilsen, Kine Marita Knudsen Sand, Muluneh Bekele Daba, Inger Øynebråten, Malin Bern, Martin B. McAdam, Stian Foss, Tilman Schlothauer, Terje E. Michaelsen, Gregory J. Christianson, Derry C. Roopenian, Richard S. Blumberg, Inger Sandlie, Jan Terje Andersen

    Udgivet 2018
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  18. 18
    An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics

    An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics af Malin Bern, Jeannette Nilsen, Mattia Ferrarese, Kine Marita Knudsen Sand, Torleif Tollefsrud Gjølberg, Heidrun Elisabeth Lode, Robert J. Davidson, Rodney M. Camire, Espen S. Bækkevold, Stian Foss, Algirdas Grevys, Bjørn Dalhus, John J. Wilson, Lene S. Høydahl, Gregory J. Christianson, Derry C. Roopenian, Tilman Schlothauer, Terje E. Michaelsen, Morten C. Moe, Silvia Lombardi, Mirko Pinotti, Inger Sandlie, Alessio Branchini, Jan Terje Andersen

    Udgivet 2020
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  19. 19
    Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

    Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria af Stian Foss, Siri Aastedatter Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette M. Scheepmaker, Line Mathiesen, Fulgencio Ruso‐Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, D. B. Bratlie, Terje E. Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette H.W. Leusen, Thomas Valerius, Sanjay Ram, Suzan H. M. Rooijakkers, Inger Sandlie, Jan Terje Andersen

    Udgivet 2024
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  20. 20
    Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies

    Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies af Frank R. Brennan, Joseph Ryan Polli, Jean G. Sathish, Melissa Ramones, Babette Wolf, Tilman Schlothauer, Shirley J. Peters, Curtis C. Maier, Changhua Ji, David Wensel, Derrick R. Witcher, Patricia C. Ryan, T. Scott Manetz, Adriano Flora, Brian W. Soper, Birgit Fogal, Lindsey Dzielak, Xiaoting Wang, Prathap Nagaraja Shastri, Karen Price, Michael Doyle, Nidhi Sharda, Mary Struthers, Maximilian Brinkhaus, Bianca Balbino, Eric Stefanich, Masaki Honda, Jan Terje Andersen, Shermaine Mitchell-Ryan, David P. Humphreys

    Udgivet 2025
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