Výsledky vyhledávání - Thomas Bohnacker

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  1. 1
    Fluid-Phase Pinocytosis of Native Low Density Lipoprotein Promotes Murine M-CSF Differentiated Macrophage Foam Cell Formation

    Fluid-Phase Pinocytosis of Native Low Density Lipoprotein Promotes Murine M-CSF Differentiated Macrophage Foam Cell Formation Autor Manoj Kumar Barthwal, Joshua J. Anzinger, Qing Xu, Thomas Bohnacker, Matthias P. Wymann, Howard S. Kruth

    Vydáno 2013
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    Artigo
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  2. 2
    PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

    PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control Autor Romy Walser, John E. Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Heß, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger Williams, Muriel Laffargue, Matthias P. Wymann

    Vydáno 2013
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  3. 3
    Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors

    Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors Autor Romina Marone, Dominik Erhart, Ann C. Mertz, Thomas Bohnacker, Christian Schnell, Vladimir Cmiljanović, Frédéric Stauffer, Carlos Garcı́a-Echeverrı́a, Bernd Giese, Sauveur-Michel Maira, Matthias P. Wymann

    Vydáno 2009
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  4. 4
    Ras is an indispensable coregulator of the class I <sub>B</sub> phosphoinositide 3-kinase p87/p110γ

    Ras is an indispensable coregulator of the class I <sub>B</sub> phosphoinositide 3-kinase p87/p110γ Autor Barbara Kurig, Aliaksei Shymanets, Thomas Bohnacker, Prajwal Prajwal, Carsten Brock, Mohammad Reza Ahmadian, Michael Schaefer, Antje Gohla, Christian Harteneck, Matthias P. Wymann, Elisabeth Jeanclos, Bernd Nürnberg

    Vydáno 2009
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  5. 5
    A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

    A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor Autor Chiara Borsari, Denise Rageot, Alix Dall’Asen, Thomas Bohnacker, Anna Melone, Alexander Sele, Eileen Jackson, Jean‐Baptiste Langlois, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, Matthias P. Wymann

    Vydáno 2019
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  6. 6
    Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

    Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and... Autor Denise Rageot, Thomas Bohnacker, Anna Melone, Jean‐Baptiste Langlois, Chiara Borsari, Petra Hillmann, Alexander Sele, Florent Beaufils, Marketa Zvelebil, Paul Hebeisen, Wolfgang Löscher, John E. Burke, Doriano Fabbro, Matthias P. Wymann

    Vydáno 2018
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  7. 7
    (<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

    (<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor... Autor Denise Rageot, Thomas Bohnacker, Erhan Keleş, Jacob A. McPhail, Reece M. Hoffmann, Anna Melone, Chiara Borsari, Rohitha Sriramaratnam, Alexander Sele, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, John E. Burke, Matthias P. Wymann

    Vydáno 2019
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  8. 8
    5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology

    5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Can... Autor Florent Beaufils, Nataša Cmiljanović, Vladimir Cmiljanović, Thomas Bohnacker, Anna Melone, Romina Marone, Eileen Jackson, Xuxiao Zhang, Alexander Sele, Chiara Borsari, Jürgen Mestan, Paul Hebeisen, Petra Hillmann, Bernd Giese, Marketa Zvelebil, Doriano Fabbro, Roger Williams, Denise Rageot, Matthias P. Wymann

    Vydáno 2017
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  9. 9
    New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease

    New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease Autor Luca Aresu, Serena Ferraresso, Laura Marconato, Luciano Cascione, Sara Napoli, Eugenio Gaudio, Ivo Kwee, Chiara Tarantelli, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Petra Hillmann, Thomas Bohnacker, Matthias P. Wymann, S. Comazzi, Massimo Milan, Fulvio Riondato, Giulia Dalla Rovere, Mery Giantin, Diana Giannuzzi, Francesco Bertoni

    Vydáno 2018
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  10. 10
    Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

    Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention Autor Thomas Bohnacker, A.E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander Sele, Vladimir Cmiljanović, Nataša Cmiljanović, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Dı́az, Doriano Fabbro, Marketa Zvelebil, Roger Williams, Michel O. Steinmetz, Matthias P. Wymann

    Vydáno 2017
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