Sökresultat - Theodore M. Kamenecka

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  1. 1
    Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile

    Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile av Xiaohai Li, Theodore M. Kamenecka, Michael D. Cameron

    Publicerad 2010
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  2. 2
    Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

    Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB av Douglas J. Kojetin, Yongjun Wang, Theodore M. Kamenecka, Thomas P. Burris

    Publicerad 2010
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  3. 3
    Pharmacologic Repression of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen‐Induced Arthritis Experimental Model

    Pharmacologic Repression of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen‐Induced Arthritis Experimental Model av Mi Ra Chang, Brent Lyda, Theodore M. Kamenecka, Patrick R. Griffin

    Publicerad 2013
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  4. 4
    Suppression of atherosclerosis by synthetic REV-ERB agonist

    Suppression of atherosclerosis by synthetic REV-ERB agonist av Sadichha Sitaula, Cyrielle Billon, Theodore M. Kamenecka, Laura A. Solt, Thomas P. Burris

    Publicerad 2015
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  5. 5
    ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes

    ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes av Laura A. Solt, Subhashis Banerjee, Sean Campbell, Theodore M. Kamenecka, Thomas P. Burris

    Publicerad 2015
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  6. 6
    Quantitative structural assessment of graded receptor agonism

    Quantitative structural assessment of graded receptor agonism av Jinsai Shang, Richard Brust, Patrick R. Griffin, Theodore M. Kamenecka, Douglas J. Kojetin

    Publicerad 2019
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  7. 7
    Insular hypocretin transmission regulates nicotine reward

    Insular hypocretin transmission regulates nicotine reward av Jonathan A. Hollander, Qun Lu, Michael D. Cameron, Theodore M. Kamenecka, Paul J. Kenny

    Publicerad 2008
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  8. 8
    Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor

    Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor av Richard Brust, Hua Lin, Jakob Fuhrmann, Alice Asteian, Theodore M. Kamenecka, Douglas J. Kojetin

    Publicerad 2017
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  9. 9
    An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors

    An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors av Jingyi Wang, Alexander Kuryatov, Aarati Sriram, Zhuang Jin, Theodore M. Kamenecka, Paul J. Kenny, Jon Lindstrom

    Publicerad 2015
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  10. 10
    Identification of a Selective RORγ Ligand That Suppresses T<sub>H</sub>17 Cells and Stimulates T Regulatory Cells

    Identification of a Selective RORγ Ligand That Suppresses T<sub>H</sub>17 Cells and Stimulates T Regulatory Cells av Laura A. Solt, Naresh Kumar, Yuanjun He, Theodore M. Kamenecka, Patrick R. Griffin, Thomas P. Burris

    Publicerad 2012
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  11. 11
    Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1

    Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1 av Paola Munoz‐Tello, Hua Lin, Pasha M. Khan, Ian Mitchelle S. de Vera, Theodore M. Kamenecka, Douglas J. Kojetin

    Publicerad 2020
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  12. 12
    Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

    Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states av Brian S. MacTavish, Di Zhu, Jinsai Shang, Qianzhen Shao, Zhongyue J Yang, Theodore M. Kamenecka, Douglas J. Kojetin

    Publicerad 2024
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  13. 13
    Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

    Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states av Brian S. MacTavish, Di Zhu, Jinsai Shang, Qianzhen Shao, Yuanjun He, Zhongyue Yang, Theodore M. Kamenecka, Douglas J. Kojetin

    Publicerad 2025
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  14. 14
    Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

    Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis av Qingzhang Zhu, S. P. Ghoshal, Ana P. C. Rodrigues, Su Gao, Alice Asterian, Theodore M. Kamenecka, James C. Barrow, Anutosh Chakraborty

    Publicerad 2016
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  15. 15
    Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator

    Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator av Naresh Kumar, Brent Lyda, Mi Ra Chang, Janelle Lauer, Laura A. Solt, Thomas P. Burris, Theodore M. Kamenecka, Patrick R. Griffin

    Publicerad 2012
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  16. 16
    PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix

    PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix av Rebecca L. Frkic, A.C. Marshall, Anne‐Laure Blayo, Tara L. Pukala, Theodore M. Kamenecka, Patrick R. Griffin, John B. Bruning

    Publicerad 2018
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  17. 17
    Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism

    Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism av John B. Bruning, Michael J. Chalmers, Swati Prasad, Scott A. Busby, Theodore M. Kamenecka, Yuanjun He, K.W. Nettles, Patrick R. Griffin

    Publicerad 2007
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  18. 18
    Synthetic RORγt Agonists Enhance Protective Immunity

    Synthetic RORγt Agonists Enhance Protective Immunity av Mi Ra Chang, Venkatasubramanian Dharmarajan, Christelle Doebelin, Rubén D. Garcia-Ordoñez, Scott J. Novick, Dana S. Kuruvilla, Theodore M. Kamenecka, Patrick R. Griffin

    Publicerad 2016
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  19. 19
    TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

    TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway av S. P. Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty

    Publicerad 2016
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  20. 20
    REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2

    REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2 av Shuo Huang, Chi‐Hsiu Liu, Zhongxiao Wang, Zhongjie Fu, William Britton, Alexandra K. Blomfield, Theodore M. Kamenecka, Joshua L. Dunaief, Laura A. Solt, Jing Chen

    Publicerad 2022
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