Výsledky vyhledávání - Takashi Ayaki

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  1. 1
    Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

    Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes Autor Takayuki Kondo, Misato Funayama, Michiyo Miyake, Kayoko Tsukita, Takumi Era, Hitoshi Osaka, Takashi Ayaki, Ryōsuke Takahashi, Haruhisa Inoue

    Vydáno 2016
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  2. 2
    Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals

    Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals Autor Yoshitaka Tamaki, Akemi Shodai, Toshifumi Morimura, Ryota Hikiami, Sumio Minamiyama, Takashi Ayaki, Ikuo Tooyama, Yoshiaki Furukawa, Ryōsuke Takahashi, Makoto Urushitani

    Vydáno 2018
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  3. 3
    Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro

    Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro Autor Megumi Asada‐Utsugi, Kengo Uemura, Takashi Ayaki, Maiko Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryōsuke Takahashi, Ayae Kinoshita, Makoto Urushitani

    Vydáno 2022
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  4. 4
    Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory

    Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory Autor Akihiro Kitamura, Satoshi Saitô, Takakuni Maki, Naoya Oishi, Takashi Ayaki, Yorito Hattori, Yumi Yamamoto, Makoto Urushitani, Raj N. Kalaria, Hidenao Fukuyama, Karen Horsburgh, Ryōsuke Takahashi, Masafumi Ihara

    Vydáno 2015
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  5. 5
    Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia

    Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia Autor Natsue Kishida, Takakuni Maki, Yasushi Takagi, Ken Yasuda, Hisanori Kinoshita, Takashi Ayaki, Takayuki Noro, Yusuke Kinoshita, Yūichi Ono, Hiroharu Kataoka, Kazumichi Yoshida, Eng H. Lo, Ken Arai, Susumu Miyamoto, Ryōsuke Takahashi

    Vydáno 2019
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  6. 6
    Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

    Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis Autor Seshiru Nakazawa, Daisuke Oikawa, Ryohei Ishii, Takashi Ayaki, Hirotaka Takahashi, Hiroyuki Takeda, Ryuichiro Ishitani, Kiyoko Kamei, Izumi Takeyoshi, Hideshi Kawakami, Kazuhiro Iwaï, Izuho Hatada, Tatsuya Sawasaki, Hidefumi Ito, Osamu Nureki, Fuminori Tokunaga

    Vydáno 2016
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  7. 7
    Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)

    Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43) Autor Akemi Shodai, Toshifumi Morimura, Akemi Ido, Tsukasa Uchida, Takashi Ayaki, Rina Takahashi, Soichiro Kitazawa, Sakura Suzuki, Mikako Shirouzu, T. Kigawa, Y. Muto, Shigeyuki Yokoyama, Ryōsuke Takahashi, Ryo Kitahara, Hidefumi Ito, Noriko Fujiwara, Makoto Urushitani

    Vydáno 2013
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  8. 8
    Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

    Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy Autor Seiji Kaji, Takakuni Maki, Hisanori Kinoshita, Norihito Uemura, Takashi Ayaki, Yasuhiro Kawamoto, Takahiro Furuta, Makoto Urushitani, Masato Hasegawa, Yusuke Kinoshita, Yūichi Ono, Xiaobo Mao, Tran H. Quach, Kazuhiro Iwaï, Valina L. Dawson, Ted M. Dawson, Ryōsuke Takahashi

    Vydáno 2018
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  9. 9
    Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant

    Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant Autor Takashi Ayaki, Hidefumi Ito, Hiroko Fukushima, Takeshi Inoue, Takayuki Kondo, Akito Ikemoto, Takeshi Asano, Akemi Shodai, Takuji Fujita, Satoshi Fukui, Hiroyuki Morino, Satoshi Nakano, Hirofumi Kusaka, Hirofumi Yamashita, Masafumi Ihara, Riki Matsumoto, Jun Kawamata, Makoto Urushitani, Hideshi Kawakami, Ryōsuke Takahashi

    Vydáno 2014
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  10. 10
    Induced pluripotent stem cell–based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients

    Induced pluripotent stem cell–based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotr... Autor Keiko Imamura, Yuishin Izumi, Haruhiko Banno, Ryuji Uozumi, Satoshi Morita, Naohiro Egawa, Takashi Ayaki, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Ryosuke Oki, Koji Fujita, Naoto Takahashi, Takafumi Ikeda, Akira Shimizu, Akiko Morinaga, Tomoko Hirohashi, Yosuke Fujii, Ryōsuke Takahashi, Haruhisa Inoue

    Vydáno 2019
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  11. 11
    Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial

    Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial Autor Keiko Imamura, Yuishin Izumi, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Naohiro Egawa, Takashi Ayaki, Ryosuke Oki, Koji Fujita, Ryuji Uozumi, Akiko Morinaga, Tomoko Hirohashi, Yosuke Fujii, Takuya Yamamoto, Harutsugu Tatebe, Takahiko Tokuda, Naoto Takahashi, Satoshi Morita, Ryōsuke Takahashi, Haruhisa Inoue

    Vydáno 2022
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  12. 12
    α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model

    α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model Autor Tomoyuki Taguchi, Masashi Ikuno, Mari Hondo, Laxmi Kumar Parajuli, Katsutoshi Taguchi, Jun Ueda, Masanori Sawamura, Shinya Okuda, Etsuro Nakanishi, Junko Hara, Norihito Uemura, Yusuke Hatanaka, Takashi Ayaki, Shu‐ichi Matsuzawa, Masaki Tanaka, Omar M. A. El‐Agnaf, Masato Koike, Masashi Yanagisawa, Maiko Uemura, Hodaka Yamakado, Ryōsuke Takahashi

    Vydáno 2019
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  13. 13
    The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

    The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis Autor Keiko Imamura, Yuishin Izumi, Akira Watanabe, Kayoko Tsukita, Knut Woltjen, Takuya Yamamoto, Akitsu Hotta, Takayuki Kondo, Shiho Kitaoka, Akira Ohta, Akito Tanaka, Dai Watanabe, Mitsuya Morita, Hiroshi Takuma, Akira Tamaoka, Tilo Kunath, Selina Wray, Hirokazu Furuya, Takumi Era, Kouki Makioka, Koichi Okamoto, Takao Fujisawa, Hideki Nishitoh, Kengo Homma, Hidenori Ichijo, Jean‐Pierre Julien, Nanako Obata, Masato Hosokawa, Haruhiko Akiyama, Satoshi Kaneko, Takashi Ayaki, Hidefumi Ito, Ryuji Kaji, Ryōsuke Takahashi, Shinya Yamanaka, Haruhisa Inoue

    Vydáno 2017
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