Výsledky vyhledávání - Steven J. Charlton

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  1. 1
    Agonist efficacy and receptor desensitization: from partial truths to a fuller picture

    Agonist efficacy and receptor desensitization: from partial truths to a fuller picture Autor Steven J. Charlton

    Vydáno 2009
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  2. 2
    Long‐lasting target binding and rebinding as mechanisms to prolong <i>in vivo</i> drug action

    Long‐lasting target binding and rebinding as mechanisms to prolong <i>in vivo</i> drug action Autor Georges Vauquelin, Steven J. Charlton

    Vydáno 2010
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  3. 3
    Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

    Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands Autor Georges Vauquelin, Steven J. Charlton

    Vydáno 2013
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  4. 4
    Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays

    Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays Autor Steven J. Charlton, Georges Vauquelin

    Vydáno 2010
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  5. 5
    Slow receptor dissociation is not a key factor in the duration of action of inhaled long‐acting β<sub>2</sub>‐adrenoceptor agonists

    Slow receptor dissociation is not a key factor in the duration of action of inhaled long‐acting β<sub>2</sub>‐adrenoceptor agonists Autor David A. Sykes, Steven J. Charlton

    Vydáno 2012
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  6. 6
    Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M<sub>3</sub>receptor

    Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M<sub>3</sub>receptor Autor Mark R. Dowling, Steven J. Charlton

    Vydáno 2006
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  7. 7
    Biased Agonism in Drug Discovery—Is It Too Soon to Choose a Path?

    Biased Agonism in Drug Discovery—Is It Too Soon to Choose a Path? Autor Martin C. Michel, Steven J. Charlton

    Vydáno 2018
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  8. 8
    Miniaturized Receptor Binding Assays: Complications Arising from Ligand Depletion

    Miniaturized Receptor Binding Assays: Complications Arising from Ligand Depletion Autor Clare M. Scaramellini Carter, Juliet Leighton-Davies, Steven J. Charlton

    Vydáno 2007
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  9. 9
    Evidence that P2Y<sub>4</sub> nucleotide receptors are involved in the regulation of rat aortic smooth muscle cells by UTP and ATP

    Evidence that P2Y<sub>4</sub> nucleotide receptors are involved in the regulation of rat aortic smooth muscle cells by UTP and ATP Autor Simon Harper, Tania E. Webb, Steven J. Charlton, Leong L. Ng, Michael R. Boarder

    Vydáno 1998
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  10. 10
    A common intracellular allosteric binding site for antagonists of the CXCR2 receptor

    A common intracellular allosteric binding site for antagonists of the CXCR2 receptor Autor Karolina Salchow, ME Bond, SC Evans, NJ Press, Steven J. Charlton, PA Hunt, ME Bradley

    Vydáno 2010
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  11. 11
    PPADS and suramin as antagonists at cloned P<sub>2Y</sub>‐ and P<sub>2U</sub>‐purinoceptors

    PPADS and suramin as antagonists at cloned P<sub>2Y</sub>‐ and P<sub>2U</sub>‐purinoceptors Autor Steven J. Charlton, Colin A. Brown, Gary A. Weisman, John T. Turner, Laurie Erb, Michael R. Boarder

    Vydáno 1996
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  12. 12
    Cloned and transfected P2Y<sub>4</sub> receptors: characterization of a suramin and PPADS‐insensitive response to UTP

    Cloned and transfected P2Y<sub>4</sub> receptors: characterization of a suramin and PPADS‐insensitive response to UTP Autor Steven J. Charlton, Colin A. Brown, Gary A. Weisman, John T. Turner, Laurie Erb, Michael R. Boarder

    Vydáno 1996
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  13. 13
    The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease

    The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease Autor Philippa R Dale, Hana Černecká, Martina Schmidt, Mark R. Dowling, Steven J. Charlton, Michael Pieper, Martin C. Michel

    Vydáno 2014
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  14. 14
    Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

    Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors Autor David A. Sykes, Holly Moore, Lisa A. Stott, Nicholas D. Holliday, Jonathan A. Javitch, J. Robert Lane, Steven J. Charlton

    Vydáno 2017
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  15. 15
    Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy

    Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy Autor David A. Sykes, Michelle Bradley, Darren Riddy, Elizabeth Willard, John Reilly, Asadh Miah, Carsten Bauer, Simon J. Watson, David A. Sandham, Gerald Dubois, Steven J. Charlton

    Vydáno 2016
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  16. 16
    Investigating the molecular mechanisms through which <scp>FTY</scp>720‐<scp>P</scp> causes persistent <scp>S1P<sub>1</sub></scp> receptor internalization

    Investigating the molecular mechanisms through which <scp>FTY</scp>720‐<scp>P</scp> causes persistent <scp>S1P<sub>1</sub></scp> receptor internalization Autor David A. Sykes, Darren Riddy, Craig Stamp, Michelle Bradley, Neil McGuiness, Afrah Sattikar, Danilo Guerini, Inês S. Rodrigues, Albrecht Glaenzel, Mark R. Dowling, Florian Müllershausen, Steven J. Charlton

    Vydáno 2014
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  17. 17
    The Antiallergic Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent Agonists of Human and Rat GPR35

    The Antiallergic Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent Agonists of Human and Rat GPR35 Autor Amanda E. Mackenzie, Gianluigi Caltabiano, Toby Kent, Laura Jenkins, Jennifer E. McCallum, Brian D. Hudson, Stuart A. Nicklin, Lindsay Fawcett, Rachel Markwick, Steven J. Charlton, Graeme Milligan

    Vydáno 2013
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  18. 18
    μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

    μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization Autor Jamie McPherson, Guadalupe Rivero, Myma Baptist, Javier Llorente, Suleiman Al‐Sabah, Cornelius Krasel, William L. Dewey, Christopher Bailey, Elizabeth M. Rosethorne, Steven J. Charlton, Graeme Henderson, Eamonn Kelly

    Vydáno 2010
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  19. 19
    Endomorphin-2: A Biased Agonist at the μ-Opioid Receptor

    Endomorphin-2: A Biased Agonist at the μ-Opioid Receptor Autor Guadalupe Rivero, Javier Llorente, Jamie McPherson, Alex Cooke, Stuart J. Mundell, Craig A. McArdle, Elizabeth M. Rosethorne, Steven J. Charlton, Cornelius Krasel, Christopher Bailey, Graeme Henderson, Eamonn Kelly

    Vydáno 2012
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  20. 20
    Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor

    Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor Autor Hsin‐Yung Yen, Idlir Liko, Wanling Song, Parth Kapoor, Fernando Almeida, Joanna Toporowska, Karolina Gherbi, Jonathan T. S. Hopper, Steven J. Charlton, Argyris Politis, Mark S.P. Sansom, Ali Jazayeri, Carol V. Robinson

    Vydáno 2022
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