Resultats de la cerca - Silvia Buonamici

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  1. 1
    The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis

    The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis per Brenton G. Mar, Dereck D. Amakye, Iannis Aifantis, Silvia Buonamici

    Publicat 2011
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  2. 2
    EVI1 induces myelodysplastic syndrome in mice

    EVI1 induces myelodysplastic syndrome in mice per Silvia Buonamici, Donglan Li, Yiqing Chi, Rui Zhao, Xuerong Wang, Larry D. Brace, Hongyu Ni, Yogen Saunthararajah, Giuseppina Nucifora

    Publicat 2004
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  3. 3
    The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

    The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia per Benjamin J. Thompson, Silvia Buonamici, Maria Luisa Sulis, Teresa Palomero, Tomas Vilimas, Giuseppe Basso, Adolfo A. Ferrando, Iannis Aifantis

    Publicat 2007
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  4. 4
    Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival

    Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival per Stefanie Chan, Praveen Sridhar, Rory Kirchner, Ying Jie Lock, Zach Herbert, Silvia Buonamici, Peter G. Smith, Judy Lieberman, Fabio Petrocca

    Publicat 2017
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  5. 5
    Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

    Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7 per Benjamin J. Thompson, Vladimir Janković, Jie Gao, Silvia Buonamici, Alan Vest, Jennifer May Lee, Jiří Zavadil, Stephen D. Nimer, Iannis Aifantis

    Publicat 2008
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  6. 6
    Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

    Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds per Constantin Cretu, Anant A. Agrawal, Andrew S. Cook, Cindy L. Will, Peter Fekkes, Peter G. Smith, Reinhard Lührmann, Nicholas Larsen, Silvia Buonamici, Vladimir Peña

    Publicat 2018
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  7. 7
    Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

    Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function per Jie Gao, Stephanie Graves, Ute Koch, Suqing Liu, Vladimir Janković, Silvia Buonamici, Abdeljabar El Andaloussi, Stephen D. Nimer, Barbara L. Kee, Russell S. Taichman, Freddy Radtke, Iannis Aifantis

    Publicat 2009
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  8. 8
    Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer

    Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer per Dingxiao Zhang, Qiang Hu, Xiaozhuo Liu, Yibing Ji, Hsueh‐Ping Chao, Yan Liu, Amanda Tracz, Jason Kirk, Silvia Buonamici, Ping Zhu, Jianmin Wang, Song Liu, Dean G. Tang

    Publicat 2020
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  9. 9
    The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

    The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action per Lorenzo I. Finci, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Teng Teng, Anant A. Agrawal, Betty Chan, Sean Irwin, Craig Karr, Andrew S. Cook, Ping Zhu, Dominic J. Reynolds, Peter G. Smith, Peter Fekkes, Silvia Buonamici, Nicholas Larsen

    Publicat 2018
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  10. 10
    Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

    Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts per Annalisa Mupo, Magdalene J. Seiler, Vijitha Sathiaseelan, Alena Pance, Yi‐Tsung Yang, Anant A. Agrawal, Francesco Iorio, Ruben Bautista, Suruchi Pacharne, Konstantinos Tzelepis, Nicla Manes, Penny Wright, Elli Papaemmanuil, David G. Kent, Peter Campbell, Silvia Buonamici, Niccolò Bolli, George S. Vassiliou

    Publicat 2016
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  11. 11
    A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

    A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia per Apostolos Klinakis, Camille Lobry, Omar Abdel‐Wahab, Philmo Oh, Hiroshi Haeno, Silvia Buonamici, Inge Van de Walle, Séverine Cathelin, Thomas Trimarchi, Elisa Araldi, Cynthia Liu, Sherif Ibrahim, Miroslav Beran, Jiří Zavadil, Argiris Efstratiadis, Tom Taghon, Franziska Michor, Ross L. Levine, Iannis Aifantis

    Publicat 2011
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  12. 12
    Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML

    Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML per Emily C. Wheeler, Benjamín Martín, William C. Doyle, Sofia Neaher, Caroline A. Conway, C Pitton, Rebecca A. Gorelov, Melanie Donahue, Johann C. Jann, Omar Abdel‐Wahab, Justin Taylor, Michael Seiler, Silvia Buonamici, Yana Pikman, Jacqueline S. Garcia, Roger Belizaire, Karen Adelman, Zuzana Tóthová

    Publicat 2024
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  13. 13
    Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

    Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma per Rocco Sciarrillo, Anna Wojtuszkiewicz, Btissame El Hassouni, Niccola Funel, Paolo Gandellini, Tonny Lagerweij, Silvia Buonamici, Maxime Blijlevens, Eveline A. Zeeuw van der Laan, Nadia Zaffaroni, Marcello Deraco, Shigeki Kusamura, Tom Würdinger, Godefridus J. Peters, Carla F.M. Molthoff, Gerrit Jansen, Gertjan J.L. Kaspers, Jacqueline Cloos, Elisa Giovannetti

    Publicat 2018
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  14. 14
    Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

    Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators per Daniel Aird, Teng Teng, Chia‐Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua J. Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson, Ping Zhu

    Publicat 2019
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  15. 15
    CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

    CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia per Silvia Buonamici, Thomas Trimarchi, Maria Grazia Ruocco, Linsey B. Reavie, Séverine Cathelin, Brenton G. Mar, Apostolos Klinakis, Yevgeniy Lukyanov, Jen‐Chieh Tseng, Filiz Şen, Eric A. Gehrie, Mengling Li, Elizabeth W. Newcomb, Jiří Zavadil, Daniel Meruelo, Martin Lipp, Sherif Ibrahim, Argiris Efstratiadis, David Zagzag, Jonathan S. Bromberg, Michael L. Dustin, Iannis Aifantis

    Publicat 2009
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  16. 16
    Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

    Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation per Esther A. Obeng, Ryan Chappell, Michael Seiler, Michelle C. Chen, Dean R. Campagna, Paul J. Schmidt, Rebekka K. Schneider, Allegra M. Lord, Lili Wang, Rutendo Gambe, Marie McConkey, Abdullah Mahmood Ali, Azra Raza, Lihua Yu, Silvia Buonamici, Peter G. Smith, Ann Mullally, Catherine J. Wu, Mark D. Fleming, Benjamin L. Ebert

    Publicat 2016
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  17. 17
    Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

    Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS per Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al‐Raqad, Manami Maeda, Vivien A. C. Schoonenberg, Mitchel A. Cole, Claudio Macias-Treviño, Yuichi Ishikawa, Qiuming Yao, Michitaka Nakano, Fumio Arai, Stuart H. Orkin, Bruno Reversade, Silvia Buonamici, Luca Pinello, Koichi Akashi, Daniel E. Bauer, Takahiro Maeda

    Publicat 2018
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  18. 18
    Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

    Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities per Mariella G. Filbin, Sukriti K. Dabral, Maria F. Pazyra‐Murphy, Shakti Ramkissoon, Andrew L. Kung, Ekaterina Pak, Jarom Y. Chung, Matthew Theisen, Yanping Sun, Yoko Franchetti, Yu Sun, David S. Shulman, Navid Redjal, Barbara Tabak, Rameen Beroukhim, Qi Wang, Jean J. Zhao, Marion Dorsch, Silvia Buonamici, Keith L. Ligon, Joseph F. Kelleher, Rosalind A. Segal

    Publicat 2013
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  19. 19
    Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

    Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins per Stanley Chun-Wei Lee, Heidi Dvinge, Eun Hee Kim, Hana Cho, Jean‐Baptiste Micol, Young Rock Chung, Benjamin H. Durham, Akihide Yoshimi, Young Joon Kim, Michaël Thomas, Camille Lobry, Chun–Wei Chen, Alessandro Pastore, Justin Taylor, Xujun Wang, Andrei V. Krivtsov, Scott A. Armstrong, James Palacino, Silvia Buonamici, Peter G. Smith, Robert K. Bradley, Omar Abdel‐Wahab

    Publicat 2016
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  20. 20
    Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

    Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex per Teng Teng, Jennifer Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Sudeep Prajapati, Daniel Aird, Silvia Buonamici, Benjamin Caleb, Betty Chan, Laura Corson, Jacob Feala, Peter Fekkes, Baudouin Gerard, Craig Karr, Manav Korpal, Xiang Liu, Jason T. Lowe, Yoshiharu Mizui, James Palacino, Eunice Park, Peter G. Smith, Vanitha Subramanian, Zhenhua J. Wu, Jian Zou, Lihua Yu, Agustin Chicas, Markus Warmuth, Nicholas Larsen, Ping Zhu

    Publicat 2017
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