検索結果 - Shamji, Alykhan

Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors 著者: Kuruvilla, Finny G., Shamji, Alykhan F., Schreiber, Stuart L.

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Small-molecule control of cytokine function: new opportunities for treating immune disorders 著者: Sundberg, Thomas B., Xavier, Ramnik J., Schreiber, Stuart L., Shamji, Alykhan F.

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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins 著者: Hardwick, James S., Kuruvilla, Finny G., Tong, Jeffrey K., Shamji, Alykhan F., Schreiber, Stuart L.

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Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway 著者: Schaefer, Giannina I., Perez, José R., Duvall, Jeremy R., Stanton, Benjamin Z., Shamji, Alykhan F., Schreiber, Stuart L.

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Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs 著者: Adams, Drew J., Dai, Mingji, Pellegrino, Giovanni, Wagner, Bridget K., Stern, Andrew M., Shamji, Alykhan F., Schreiber, Stuart L.

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A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma 著者: Yuan, Yuan, Wang, Qiu, Paulk, Joshiawa, Kubicek, Stefan, Kemp, Melissa M., Adams, Drew J., Shamji, Alykhan F., Wagner, Bridget K., Schreiber, Stuart L.

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Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles 著者: Clemons, Paul A., Bodycombe, Nicole E., Carrinski, Hyman A., Wilson, J. Anthony, Shamji, Alykhan F., Wagner, Bridget K., Koehler, Angela N., Schreiber, Stuart L.

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Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death 著者: Adams, Drew J., Boskovic, Zarko V., Theriault, Jimmy R., Wang, Alex J., Stern, Andrew M., Wagner, Bridget K., Shamji, Alykhan F., Schreiber, Stuart L.

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Automated structure–activity relationship mining: connecting chemical structure to biological profiles 著者: Wawer, Mathias J., Jaramillo, David E., Dancik, Vlado, Fass, Daniel M., Haggarty, Stephen J., Shamji, Alykhan F., Wagner, Bridget K., Schreiber, Stuart L., Clemons, Paul A.

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Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses 著者: Dančík, Vlado, Carrel, Hyman, Bodycombe, Nicole E., Seiler, Kathleen Petri, Fomina-Yadlin, Dina, Kubicek, Stefan T., Hartwell, Kimberly, Shamji, Alykhan F., Wagner, Bridget K., Clemons, Paul A.

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Small-molecule inducers of insulin expression in pancreatic α-cells 著者: Fomina-Yadlin, Dina, Kubicek, Stefan, Walpita, Deepika, Dančik, Vlado, Hecksher-Sørensen, Jacob, Bittker, Joshua A., Sharifnia, Tanaz, Shamji, Alykhan, Clemons, Paul A., Wagner, Bridget K., Schreiber, Stuart L.

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A Human Islet Cell Culture System for High-Throughput Screening 著者: Walpita, Deepika, Hasaka, Thomas, Spoonamore, James, Vetere, Amedeo, Takane, Karen K., Fomina-Yadlin, Dina, Fiaschi-Taesch, Nathalie, Shamji, Alykhan, Clemons, Paul A., Stewart, Andrew F., Schreiber, Stuart L., Wagner, Bridget K.

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NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes 著者: Adams, Drew J., Ito, Daisuke, Rees, Matthew G., Seashore-Ludlow, Brinton, Puyang, Xiaoling, Ramos, Alex H., Cheah, Jaime H., Clemons, Paul A., Warmuth, Markus, Zhu, Ping, Shamji, Alykhan F., Schreiber, Stuart L.

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Discovery of a Small-Molecule Probe for V-ATPase Function 著者: Aldrich, Leslie N., Kuo, Szu-Yu, Castoreno, Adam B., Goel, Gautam, Kuballa, Petric, Rees, Matthew G., Seashore-Ludlow, Brinton A., Cheah, Jaime H., Latorre, Isabel J., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.

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Selective killing of cancer cells with a small molecule targeting stress response to ROS 著者: Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U, Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.

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Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS 著者: Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.

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Multiplex Cytological Profiling Assay to Measure Diverse Cellular States 著者: Gustafsdottir, Sigrun M., Ljosa, Vebjorn, Sokolnicki, Katherine L., Anthony Wilson, J., Walpita, Deepika, Kemp, Melissa M., Petri Seiler, Kathleen, Carrel, Hyman A., Golub, Todd R., Schreiber, Stuart L., Clemons, Paul A., Carpenter, Anne E., Shamji, Alykhan F.

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Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1 著者: Law, Jason M., Stark, Sebastian C., Liu, Ke, Liang, Norah E., Hussain, Mahmud M., Leiendecker, Matthias, Ito, Daisuke, Verho, Oscar, Stern, Andrew M., Johnston, Stephen E., Zhang, Yan-Ling, Dunn, Gavin P., Shamji, Alykhan F., Schreiber, Stuart L.

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Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells 著者: Kubicek, Stefan, Gilbert, Joshua C., Fomina-Yadlin, Dina, Gitlin, Alexander D., Yuan, Yuan, Wagner, Florence F., Holson, Edward B., Luo, Tuoping, Lewis, Timothy A., Taylor, Bradley, Gupta, Supriya, Shamji, Alykhan F., Wagner, Bridget K., Clemons, Paul A., Schreiber, Stuart L.

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Selective modulation of autophagy, innate immunity and adaptive immunity by small molecules 著者: Shaw, Stanley Y., Tran, Khoa, Castoreno, Adam B., Peloquin, Joanna M., Lassen, Kara G., Khor, Bernard, Aldrich, Leslie N., Tan, Pauline H., Graham, Daniel B., Kuballa, Petric, Goel, Gautam, Daly, Mark J., Shamji, Alykhan F., Schreiber, Stuart L., Xavier, Ramnik J.

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