Resultats de la cerca - Sean Uryu

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  1. 1
    FAK promotes recruitment of talin to nascent adhesions to control cell motility

    FAK promotes recruitment of talin to nascent adhesions to control cell motility per Christine Lawson, Ssang‐Taek Lim, Sean Uryu, Xiao Lei Chen, David Calderwood, David D. Schlaepfer

    Publicat 2012
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  2. 2
    FAK promotes recruitment of talin to nascent adhesions to control cell motility

    FAK promotes recruitment of talin to nascent adhesions to control cell motility per Christine Lawson, Ssang‐Taek Lim, Sean Uryu, Xiao Lei Chen, David Calderwood, David D. Schlaepfer

    Publicat 2012
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  3. 3
    Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells

    Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells per Zhiwen Zhang, Lital Alfonta, Feng Tian, Badry Bursulaya, Sean Uryu, David S. King, Peter G. Schultz

    Publicat 2004
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  4. 4
    FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

    FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth per Isabelle Tancioni, Nichol Miller, Sean Uryu, Christine Lawson, Christine Jean, Xiao Lei Chen, Elizabeth G. Kleinschmidt, David D. Schlaepfer

    Publicat 2015
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  5. 5
    FAK Inhibition Disrupts a β5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth

    FAK Inhibition Disrupts a β5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth per Isabelle Tancioni, Sean Uryu, Florian J. Sulzmaier, Nina R. Shah, Christine Lawson, Nichol Miller, Christine Jean, Xiao Lei Chen, Kristy Ward, David D. Schlaepfer

    Publicat 2014
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  6. 6
    Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

    Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression per Ssang‐Taek Lim, Nichol Miller, Xiao Lei Chen, Isabelle Tancioni, Colin Walsh, Christine Lawson, Sean Uryu, Sara M. Weis, David A. Cheresh, David D. Schlaepfer

    Publicat 2012
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  7. 7
    Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

    Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer per Nina R. Shah, Isabelle Tancioni, Kristy Ward, Christine Lawson, Xiao Lei Chen, Christine Jean, Florian J. Sulzmaier, Sean Uryu, Nichol Miller, Denise C. Connolly, David D. Schlaepfer

    Publicat 2014
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  8. 8
    Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

    Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models per Colin Walsh, Isabelle Tanjoni, Sean Uryu, Alok Tomar, Ju‐Ock Nam, Hong Luo, Angelica Phillips, Neela Patel, Cheni Kwok, Gerald McMahon, Dwayne G. Stupack, David D. Schlaepfer

    Publicat 2010
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  9. 9
    Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

    Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression per Kristy Ward, Isabelle Tancioni, Christine Lawson, Nichol Miller, Christine Jean, Xiao Lei Chen, Sean Uryu, Josephine Kim, David G. Jackson, Dwayne G. Stupack, Steven C. Plaxe, David D. Schlaepfer

    Publicat 2012
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  10. 10
    PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

    PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments per Isabelle Tanjoni, Colin Walsh, Sean Uryu, Alok Tomar, Ju‐Ock Nam, Ainhoa Mielgo, Ssang‐Taek Lim, Congxin Liang, Marcel Koenig, Neela Patel, Cheni Kwok, Gerald McMahon, Dwayne G. Stupack, David D. Schlaepfer

    Publicat 2010
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  11. 11
    Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility

    Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility per Lin Wu, Joie A. Bernard‐Trifilo, Youngkyoung Lim, Ssang‐Taek Lim, Subir K. Mitra, Sean Uryu, Min Chen, Catherine J. Pallen, N K Cheung, David Mikolon, Ainhoa Mielgo, Dwayne G. Stupack, David D. Schlaepfer

    Publicat 2007
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  12. 12
    Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

    Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function per Christine Jean, Xiao Lei Chen, Ju‐Ock Nam, Isabelle Tancioni, Sean Uryu, Christine Lawson, Kristy Ward, Colin Walsh, Nichol Miller, Majid Ghassemian, Patric Turowski, Elisabetta Dejana, Sara M. Weis, David A. Cheresh, David D. Schlaepfer

    Publicat 2014
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  13. 13
    VEGF-Induced Vascular Permeability Is Mediated by FAK

    VEGF-Induced Vascular Permeability Is Mediated by FAK per Xiao Lei Chen, Ju‐Ock Nam, Christine Jean, Christine Lawson, Colin Walsh, Erik T. Goka, Ssang‐Taek Lim, Alok Tomar, Isabelle Tancioni, Sean Uryu, Jun‐Lin Guan, Lisette M. Acevedo, Sara M. Weis, David A. Cheresh, David D. Schlaepfer

    Publicat 2012
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  14. 14
    PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

    PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility per Yangmi Lim, Ssang‐Taek Lim, Alok Tomar, Margaret L. Gardel, Joie A. Bernard‐Trifilo, Xiao Lei Chen, Sean Uryu, Rafaela Cañete-Soler, Jinbin Zhai, Hong Lin, William W. Schlaepfer, Perihan Nalbant, Gary Bokoch, Duško Ilić, Clare M. Waterman, David D. Schlaepfer

    Publicat 2008
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  15. 15
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy per Carlos J. Díaz Osterman, Duygu Ozmadenci, Elizabeth G. Kleinschmidt, Kristin Taylor, A. Barrie, Shulin Jiang, L.M. Bean, Florian J. Sulzmaier, Christine Jean, Isabelle Tancioni, Kristen Anderson, Sean Uryu, Edward A. Cordasco, Jian Li, Xiao Lei Chen, Guo Fu, Marjaana Ojalill, Pekka Rappu, Jyrki Heino, Adam M. Mark, Guorong Xu, Kathleen M. Fisch, Vihren N. Kolev, David T. Weaver, Jonathan A. Pachter, Balázs Győrffy, Michael McHale, Denise C. Connolly, Alfredo Molinolo, Dwayne G. Stupack, David D. Schlaepfer

    Publicat 2019
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  16. 16
    Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (<i>R</i>)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (PF-06821497)

    Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (<i>R</... per Pei‐Pei Kung, Patrick Bingham, Alexei Brooun, Michael R. Collins, Ya‐Li Deng, Dac M. Dinh, Connie Fan, K.S. Gajiwala, Rita Grantner, Hovhannes J. Gukasyan, Wenyue Hu, Buwen Huang, Robert S. Kania, Susan E. Kephart, Cody Krivacic, Robert A. Kumpf, Penney Khamphavong, Manfred Kraus, Wei Liu, Karen A. Maegley, Lisa Nguyen, Shijian Ren, Dan Richter, Robert A. Rollins, Neal W. Sach, Shikhar Sharma, John Sherrill, Jillian E. Spangler, Albert Stewart, Scott C. Sutton, Sean Uryu, Dominique Verhelle, Hui Wang, Shuiwang Wang, Martin Wythes, Shuibo Xin, Shinji Yamazaki, Huichun Zhu, JinJiang Zhu, Luke R. Zehnder, Martin P. Edwards

    Publicat 2017
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  17. 17
    Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

    Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer per Shikhar Sharma, Chi‐Yeh Chung, Sean Uryu, Jelena Petrovic, Joan Cao, Amanda J. Rickard, Nataliya Nady, S.E. Greasley, Eric F. Johnson, Oleg Brodsky, Showkhin Khan, Hui Wang, Zhenxiong Wang, Yong Zhang, Konstantinos Tsaparikos, Lei Chen, Anthony Mazurek, John D. Lapek, Pei‐Pei Kung, Scott C. Sutton, Paul Richardson, Eric C. Greenwald, Shinji Yamazaki, Rhys Jones, Karen A. Maegley, Patrick Bingham, Hieu Lam, Alexandra E. Stupple, Aileen Kamal, Anderly C. Chüeh, Anthony N. Cuzzupe, Benjamin J. Morrow, Bin Ren, Catalina Carrasco‐Pozo, Chin Wee Tan, Dharmesh D. Bhuva, Elizabeth Allan, Elliot Surgenor, François Vaillant, Havva Pehlivanoglu, Hendrik Falk, James R. Whittle, Janet Newman, Joseph Cursons, Judy P. Doherty, Karen L. White, Laura MacPherson, Mark Devlin, Matthew L. Dennis, Meghan Hattarki, Melanie de Silva, Michelle A. Camerino, Miriam Butler, Olan Dolezal, Patricia A. Pilling, Richard C. Foitzik, Paul A. Stupple, H. Rachel Lagiakos, Scott R. Walker, Soroor Hediyeh-zadeh, Stewart D. Nuttall, Sukhdeep K. Spall, Susan A. Charman, Theresa Connor, Thomas S. Peat, Vicky M. Avery, Ylva E. Bozikis, Yuqing Yang, Ming Zhang, Brendon Monahan, Anne K. Voss, Tim Thomas, Ian P. Street, Sarah‐Jane Dawson, Mark A. Dawson, Geoffrey J. Lindeman, Melissa J. Davis, Jane E. Visvader, Thomas A. Paul

    Publicat 2023
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