Torthaí cuardaigh - Schoeberl, Birgit

An expanding role for cell biologists in drug discovery and pharmacology de réir Sorger, Peter K., Schoeberl, Birgit

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Competing Docking Interactions can Bring About Bistability in the MAPK Cascade de réir Legewie, Stefan, Schoeberl, Birgit, Blüthgen, Nils, Herzel, Hanspeter

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Tensor clustering with algebraic constraints gives interpretable groups of crosstalk mechanisms in breast cancer de réir Seigal, Anna, Beguerisse-Díaz, Mariano, Schoeberl, Birgit, Niepel, Mario, Harrington, Heather A.

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Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles de réir Kanodia, Jitendra, Chai, Diana, Vollmer, Jannik, Kim, Jaeyeon, Raue, Andreas, Finn, Greg, Schoeberl, Birgit

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Autocrine signaling is a key regulatory element during osteoclastogenesis de réir Kopesky, Paul, Tiedemann, Kerstin, Alkekhia, Dahlia, Zechner, Christoph, Millard, Bjorn, Schoeberl, Birgit, Komarova, Svetlana V.

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Effects of Insulin-like Growth Factor-1 and Dexamethasone on Cytokine-Challenged Cartilage: Relevance to Post Traumatic Osteoarthritis de réir Li, Yang, Wang, Yang, Chubinskaya, Susanna, Schoeberl, Birgit, Florine, Emily, Kopesky, Paul, Grodzinsky, Alan J.

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Estimation of immune cell content in tumour tissue using single-cell RNA-seq data de réir Schelker, Max, Feau, Sonia, Du, Jinyan, Ranu, Nav, Klipp, Edda, MacBeath, Gavin, Schoeberl, Birgit, Raue, Andreas

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Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data de réir Chen, William W, Schoeberl, Birgit, Jasper, Paul J, Niepel, Mario, Nielsen, Ulrik B, Lauffenburger, Douglas A, Sorger, Peter K

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Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines de réir Niepel, Mario, Hafner, Marc, Pace, Emily A., Chung, Mirra, Chai, Diana H., Zhou, Lili, Schoeberl, Birgit, Sorger, Peter K.

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HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B de réir Kirouac, Daniel C., Du, Jinyan, Lahdenranta, Johanna, Onsum, Matthew D., Nielsen, Ulrik B., Schoeberl, Birgit, McDonagh, Charlotte F.

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Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making de réir Kondic, Anna, Bottino, Dean, Harrold, John, Kearns, Jeffrey D., Musante, CJ, Odinecs, Aleksandrs, Ramanujan, Saroja, Selimkhanov, Jangir, Schoeberl, Birgit

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Analysis of growth factor signaling in genetically diverse breast cancer lines de réir Niepel, Mario, Hafner, Marc, Pace, Emily A, Chung, Mirra, Chai, Diana H, Zhou, Lili, Muhlich, Jeremy L, Schoeberl, Birgit, Sorger, Peter K

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Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies de réir Zhou, Yu, Goenaga, Anne-Laure, Harms, Brian D., Zou, Hao, Lou, Jianlong, Conrad, Fraser, Adams, Gregory P., Schoeberl, Birgit, Nielsen, Ulrik B., Marks, James D.

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Predicting ligand-dependent tumors from multi-dimensional signaling features de réir Hass, Helge, Masson, Kristina, Wohlgemuth, Sibylle, Paragas, Violette, Allen, John E., Sevecka, Mark, Pace, Emily, Timmer, Jens, Stelling, Joerg, MacBeath, Gavin, Schoeberl, Birgit, Raue, Andreas

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Rapid optimization and prototyping for therapeutic antibody-like molecules de réir Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Jiao, Yang, Razlog, Maja, Zhang, Kathy, Baum, Jason, Johnson, Bryan, Tang, Jian, Schoeberl, Birgit, Fitzgerald, Jonathan, Nielsen, Ulrik, Lugovskoy, Alexey A.

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Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer de réir Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios

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Ten simple rules to power drug discovery with data science de réir Ferrero, Enrico, Brachat, Sophie, Jenkins, Jeremy L., Marc, Philippe, Skewes-Cox, Peter, Altshuler, Robert C., Gubser Keller, Caroline, Kauffmann, Audrey, Sassaman, Erik K., Laramie, Jason M., Schoeberl, Birgit, Borowsky, Mark L., Stiefl, Nikolaus

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An ErbB3 antibody, MM-121, is active in cancers with ligand dependent activation de réir Schoeberl, Birgit, Faber, Anthony C., Li, Danan, Liang, Mei-Chih, Crosby, Katherine, Onsum, Matthew, Burenkova, Olga, Pace, Emily, Walton, Zandra, Nie, Lin, Fulgham, Aaron, Song, Youngchul, Nielsen, Ulrik B., Engelman, Jeffrey A., Wong, Kwok-Kin

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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells de réir Sheng, Qing, Liu, Xinggang, Fleming, Eleanor, Yuan, Karen, Piao, Huiying, Chen, Jinyun, Moustafa, Zeinab, Thomas, Roman K., Greulich, Heidi, Schinzel, Anna, Zaghlul, Sara, Batt, David, Ettenberg, Seth, Meyerson, Matthew, Schoeberl, Birgit, Kung, Andrew L., Hahn, William C., Drapkin, Ronny, Livingston, David M., Liu, Joyce F.

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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM de réir Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

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