Søgeresultater - Schoeberl, Birgit

An expanding role for cell biologists in drug discovery and pharmacology af Sorger, Peter K., Schoeberl, Birgit

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Competing Docking Interactions can Bring About Bistability in the MAPK Cascade af Legewie, Stefan, Schoeberl, Birgit, Blüthgen, Nils, Herzel, Hanspeter

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Tensor clustering with algebraic constraints gives interpretable groups of crosstalk mechanisms in breast cancer af Seigal, Anna, Beguerisse-Díaz, Mariano, Schoeberl, Birgit, Niepel, Mario, Harrington, Heather A.

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Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles af Kanodia, Jitendra, Chai, Diana, Vollmer, Jannik, Kim, Jaeyeon, Raue, Andreas, Finn, Greg, Schoeberl, Birgit

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Autocrine signaling is a key regulatory element during osteoclastogenesis af Kopesky, Paul, Tiedemann, Kerstin, Alkekhia, Dahlia, Zechner, Christoph, Millard, Bjorn, Schoeberl, Birgit, Komarova, Svetlana V.

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Effects of Insulin-like Growth Factor-1 and Dexamethasone on Cytokine-Challenged Cartilage: Relevance to Post Traumatic Osteoarthritis af Li, Yang, Wang, Yang, Chubinskaya, Susanna, Schoeberl, Birgit, Florine, Emily, Kopesky, Paul, Grodzinsky, Alan J.

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Estimation of immune cell content in tumour tissue using single-cell RNA-seq data af Schelker, Max, Feau, Sonia, Du, Jinyan, Ranu, Nav, Klipp, Edda, MacBeath, Gavin, Schoeberl, Birgit, Raue, Andreas

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Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data af Chen, William W, Schoeberl, Birgit, Jasper, Paul J, Niepel, Mario, Nielsen, Ulrik B, Lauffenburger, Douglas A, Sorger, Peter K

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Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines af Niepel, Mario, Hafner, Marc, Pace, Emily A., Chung, Mirra, Chai, Diana H., Zhou, Lili, Schoeberl, Birgit, Sorger, Peter K.

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HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B af Kirouac, Daniel C., Du, Jinyan, Lahdenranta, Johanna, Onsum, Matthew D., Nielsen, Ulrik B., Schoeberl, Birgit, McDonagh, Charlotte F.

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Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making af Kondic, Anna, Bottino, Dean, Harrold, John, Kearns, Jeffrey D., Musante, CJ, Odinecs, Aleksandrs, Ramanujan, Saroja, Selimkhanov, Jangir, Schoeberl, Birgit

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Analysis of growth factor signaling in genetically diverse breast cancer lines af Niepel, Mario, Hafner, Marc, Pace, Emily A, Chung, Mirra, Chai, Diana H, Zhou, Lili, Muhlich, Jeremy L, Schoeberl, Birgit, Sorger, Peter K

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Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies af Zhou, Yu, Goenaga, Anne-Laure, Harms, Brian D., Zou, Hao, Lou, Jianlong, Conrad, Fraser, Adams, Gregory P., Schoeberl, Birgit, Nielsen, Ulrik B., Marks, James D.

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Predicting ligand-dependent tumors from multi-dimensional signaling features af Hass, Helge, Masson, Kristina, Wohlgemuth, Sibylle, Paragas, Violette, Allen, John E., Sevecka, Mark, Pace, Emily, Timmer, Jens, Stelling, Joerg, MacBeath, Gavin, Schoeberl, Birgit, Raue, Andreas

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Rapid optimization and prototyping for therapeutic antibody-like molecules af Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Jiao, Yang, Razlog, Maja, Zhang, Kathy, Baum, Jason, Johnson, Bryan, Tang, Jian, Schoeberl, Birgit, Fitzgerald, Jonathan, Nielsen, Ulrik, Lugovskoy, Alexey A.

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Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer af Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios

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Ten simple rules to power drug discovery with data science af Ferrero, Enrico, Brachat, Sophie, Jenkins, Jeremy L., Marc, Philippe, Skewes-Cox, Peter, Altshuler, Robert C., Gubser Keller, Caroline, Kauffmann, Audrey, Sassaman, Erik K., Laramie, Jason M., Schoeberl, Birgit, Borowsky, Mark L., Stiefl, Nikolaus

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An ErbB3 antibody, MM-121, is active in cancers with ligand dependent activation af Schoeberl, Birgit, Faber, Anthony C., Li, Danan, Liang, Mei-Chih, Crosby, Katherine, Onsum, Matthew, Burenkova, Olga, Pace, Emily, Walton, Zandra, Nie, Lin, Fulgham, Aaron, Song, Youngchul, Nielsen, Ulrik B., Engelman, Jeffrey A., Wong, Kwok-Kin

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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells af Sheng, Qing, Liu, Xinggang, Fleming, Eleanor, Yuan, Karen, Piao, Huiying, Chen, Jinyun, Moustafa, Zeinab, Thomas, Roman K., Greulich, Heidi, Schinzel, Anna, Zaghlul, Sara, Batt, David, Ettenberg, Seth, Meyerson, Matthew, Schoeberl, Birgit, Kung, Andrew L., Hahn, William C., Drapkin, Ronny, Livingston, David M., Liu, Joyce F.

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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM af Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

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