Canlyniadau Chwilio - Schoeberl, Birgit

An expanding role for cell biologists in drug discovery and pharmacology gan Sorger, Peter K., Schoeberl, Birgit

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Competing Docking Interactions can Bring About Bistability in the MAPK Cascade gan Legewie, Stefan, Schoeberl, Birgit, Blüthgen, Nils, Herzel, Hanspeter

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Tensor clustering with algebraic constraints gives interpretable groups of crosstalk mechanisms in breast cancer gan Seigal, Anna, Beguerisse-Díaz, Mariano, Schoeberl, Birgit, Niepel, Mario, Harrington, Heather A.

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Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles gan Kanodia, Jitendra, Chai, Diana, Vollmer, Jannik, Kim, Jaeyeon, Raue, Andreas, Finn, Greg, Schoeberl, Birgit

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Autocrine signaling is a key regulatory element during osteoclastogenesis gan Kopesky, Paul, Tiedemann, Kerstin, Alkekhia, Dahlia, Zechner, Christoph, Millard, Bjorn, Schoeberl, Birgit, Komarova, Svetlana V.

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Effects of Insulin-like Growth Factor-1 and Dexamethasone on Cytokine-Challenged Cartilage: Relevance to Post Traumatic Osteoarthritis gan Li, Yang, Wang, Yang, Chubinskaya, Susanna, Schoeberl, Birgit, Florine, Emily, Kopesky, Paul, Grodzinsky, Alan J.

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Estimation of immune cell content in tumour tissue using single-cell RNA-seq data gan Schelker, Max, Feau, Sonia, Du, Jinyan, Ranu, Nav, Klipp, Edda, MacBeath, Gavin, Schoeberl, Birgit, Raue, Andreas

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Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data gan Chen, William W, Schoeberl, Birgit, Jasper, Paul J, Niepel, Mario, Nielsen, Ulrik B, Lauffenburger, Douglas A, Sorger, Peter K

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Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines gan Niepel, Mario, Hafner, Marc, Pace, Emily A., Chung, Mirra, Chai, Diana H., Zhou, Lili, Schoeberl, Birgit, Sorger, Peter K.

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HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B gan Kirouac, Daniel C., Du, Jinyan, Lahdenranta, Johanna, Onsum, Matthew D., Nielsen, Ulrik B., Schoeberl, Birgit, McDonagh, Charlotte F.

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Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making gan Kondic, Anna, Bottino, Dean, Harrold, John, Kearns, Jeffrey D., Musante, CJ, Odinecs, Aleksandrs, Ramanujan, Saroja, Selimkhanov, Jangir, Schoeberl, Birgit

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Analysis of growth factor signaling in genetically diverse breast cancer lines gan Niepel, Mario, Hafner, Marc, Pace, Emily A, Chung, Mirra, Chai, Diana H, Zhou, Lili, Muhlich, Jeremy L, Schoeberl, Birgit, Sorger, Peter K

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Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies gan Zhou, Yu, Goenaga, Anne-Laure, Harms, Brian D., Zou, Hao, Lou, Jianlong, Conrad, Fraser, Adams, Gregory P., Schoeberl, Birgit, Nielsen, Ulrik B., Marks, James D.

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Predicting ligand-dependent tumors from multi-dimensional signaling features gan Hass, Helge, Masson, Kristina, Wohlgemuth, Sibylle, Paragas, Violette, Allen, John E., Sevecka, Mark, Pace, Emily, Timmer, Jens, Stelling, Joerg, MacBeath, Gavin, Schoeberl, Birgit, Raue, Andreas

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Rapid optimization and prototyping for therapeutic antibody-like molecules gan Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Jiao, Yang, Razlog, Maja, Zhang, Kathy, Baum, Jason, Johnson, Bryan, Tang, Jian, Schoeberl, Birgit, Fitzgerald, Jonathan, Nielsen, Ulrik, Lugovskoy, Alexey A.

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Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer gan Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios

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Ten simple rules to power drug discovery with data science gan Ferrero, Enrico, Brachat, Sophie, Jenkins, Jeremy L., Marc, Philippe, Skewes-Cox, Peter, Altshuler, Robert C., Gubser Keller, Caroline, Kauffmann, Audrey, Sassaman, Erik K., Laramie, Jason M., Schoeberl, Birgit, Borowsky, Mark L., Stiefl, Nikolaus

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An ErbB3 antibody, MM-121, is active in cancers with ligand dependent activation gan Schoeberl, Birgit, Faber, Anthony C., Li, Danan, Liang, Mei-Chih, Crosby, Katherine, Onsum, Matthew, Burenkova, Olga, Pace, Emily, Walton, Zandra, Nie, Lin, Fulgham, Aaron, Song, Youngchul, Nielsen, Ulrik B., Engelman, Jeffrey A., Wong, Kwok-Kin

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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells gan Sheng, Qing, Liu, Xinggang, Fleming, Eleanor, Yuan, Karen, Piao, Huiying, Chen, Jinyun, Moustafa, Zeinab, Thomas, Roman K., Greulich, Heidi, Schinzel, Anna, Zaghlul, Sara, Batt, David, Ettenberg, Seth, Meyerson, Matthew, Schoeberl, Birgit, Kung, Andrew L., Hahn, William C., Drapkin, Ronny, Livingston, David M., Liu, Joyce F.

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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM gan Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

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