نتائج البحث - Sangodkar, Jaya

The impact of phosphatases on proliferative and survival signaling in cancer حسب Narla, Goutham, Sangodkar, Jaya, Ryder, Christopher B.

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Targeting PP2A in cancer: Combination therapies حسب Mazhar, Sahar, Taylor, Sarah E., Sangodkar, Jaya, Narla, Goutham

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Therapeutic Targeting of PP2A حسب O’Connor, Caitlin M., Perl, Abbey, Leonard, Daniel, Sangodkar, Jaya, Narla, Goutham

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All roads lead to PP2A: Exploiting the therapeutic potential of this phosphatase حسب Sangodkar, Jaya, Farrington, Caroline, McClinch, Kimberly, Galsky, Matthew D., Kastrinsky, David B., Narla, Goutham

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Reengineered tricyclic anti-cancer agents حسب Kastrinsky, David B., Sangodkar, Jaya, Zaware, Nilesh, Izadmehr, Sudeh, Dhawan, Neil S., Narla, Goutham, Ohlmeyer, Michael

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KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model حسب DiFeo, Analisa, Huang, Fei, Sangodkar, Jaya, Terzo, Esteban A., Leake, Devin, Narla, Goutham, Martignetti, John A.

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Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma حسب Sangodkar, Jaya, DiFeo, Analisa, Feld, Lauren, Bromberg, Romina, Huang, Fei, Terzo, Esteban A., Choudhri, Aisha, Narla, Goutham

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Phosphoproteomics Profiling of Non-Small Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator حسب Wiredja, Danica D., Ayati, Marzieh, Mazhar, Sahar, Sangodkar, Jaya, Maxwell, Sean, Schlatzer, Daniela, Narla, Goutham, Koyutürk, Mehmet, Chance, Mark R.

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PP2A-activating drugs enhance FLT3 inhibitor efficacy through AKT inhibition-dependent GSK-3β-mediated c-Myc and Pim-1 proteasomal degradation حسب Scarpa, Mario, Singh, Prerna, Bailey, Christopher M., Lee, Jonelle K., Kapoor, Shivani, Lapidus, Rena G., Niyongere, Sandrine, Sangodkar, Jaya, Wang, Yin, Perrotti, Danilo, Narla, Goutham, Baer, Maria R.

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Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers حسب Farrington, Caroline C., Yuan, Eric, Mazhar, Sahar, Izadmehr, Sudeh, Hurst, Lauren, Allen-Petersen, Brittany L., Janghorban, Mahnaz, Chung, Eric, Wolczanski, Grace, Galsky, Matthew, Sears, Rosalie, Sangodkar, Jaya, Narla, Goutham

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Direct activation of PP2A for the treatment of tyrosine kinase inhibitor–resistant lung adenocarcinoma حسب Tohmé, Rita, Izadmehr, Sudeh, Gandhe, Sai, Tabaro, Giancarlo, Vallabhaneni, Sanjay, Thomas, Ava, Vasireddi, Neal, Dhawan, Neil S., Ma’ayan, Avi, Sharma, Neelesh, Galsky, Matthew D., Ohlmeyer, Michael, Sangodkar, Jaya, Narla, Goutham

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Sprague Dawley Rag2 null rats created from engineered spermatogonial stem cells are immunodeficient and permissive to human xenografts حسب Noto, Fallon K., Adjan-Steffey, Valeriya, Tong, Min, Ravichandran, Kameswaran, Zhang, Wei, Arey, Angela, McClain, Christopher B., Ostertag, Eric, Mazhar, Sahar, Sangodkar, Jaya, DiFeo, Analisa, Crawford, Jack, Narla, Goutham, Jamling, Tseten Y.

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KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis حسب Narla, Goutham, DiFeo, Analisa, Fernandez, Yolanda, Dhanasekaran, Saravana, Huang, Fei, Sangodkar, Jaya, Hod, Eldad, Leake, Devin, Friedman, Scott L., Hall, Simon J., Chinnaiyan, Arul M., Gerald, William L., Rubin, Mark A., Martignetti, John A.

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Functional role of the KLF6 tumour suppressor gene in gastric cancer حسب Sangodkar, Jaya, Shi, Jiayan, DiFeo, Analisa, Schwartz, Rachel, Bromberg, Romina, Choudhri, Aisha, McClinch, Kim, Hatami, Raheleh, Scheer, Elias, Kremer-Tal, Sigal, Martignetti, John A, Hui, Alex, Leung, WK, Friedman, Scott L, Narla, Goutham

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Targeting ribonucleotide reductase induces synthetic lethality in PP2A-deficient uterine serous carcinoma حسب O’Connor, Caitlin M., Taylor, Sarah E., Miller, Kathryn M., Hurst, Lauren, Haanen, Terrance J., Suhan, Tahra K., Zawacki, Kaitlin P., Noto, Fallon K., Trako, Jonida, Mohan, Arathi, Sangodkar, Jaya, Zamarin, Dmitriy, DiFeo, Analisa, Narla, Goutham

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PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells حسب Kauko, Otto, O’Connor, Caitlin M., Kulesskiy, Evgeny, Sangodkar, Jaya, Aakula, Anna, Izadmehr, Sudeh, Yetukuri, Laxman, Yadav, Bhagwan, Padzik, Artur, Laajala, Teemu Daniel, Haapaniemi, Pekka, Momeny, Majid, Varila, Taru, Ohlmeyer, Michael, Aittokallio, Tero, Wennerberg, Krister, Narla, Goutham, Westermarck, Jukka

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Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response حسب Sangodkar, Jaya, Dhawan, Neil S., Melville, Heather, Singh, Varan J., Yuan, Eric, Rana, Huma, Izadmehr, Sudeh, Farrington, Caroline, Mazhar, Sahar, Katz, Suzanna, Albano, Tara, Arnovitz, Pearlann, Okrent, Rachel, Ohlmeyer, Michael, Galsky, Matthew, Burstein, David, Zhang, David, Politi, Katerina, DiFeo, Analisa, Narla, Goutham

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Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors حسب O’Connor, Caitlin M., Leonard, Daniel, Wiredja, Danica, Avelar, Rita A., Wang, Zhizhi, Schlatzer, Daniela, Bryson, Benjamin, Tokala, Eesha, Taylor, Sarah E., Upadhyay, Aditya, Sangodkar, Jaya, Gingras, Anne-Claude, Westermarck, Jukka, Xu, Wenqing, DiFeo, Analisa, Brautigan, David L., Haider, Shozeb, Jackson, Mark, Narla, Goutham

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The highly recurrent PP2A Aα-subunit mutation P179R alters protein structure and impairs PP2A enzyme function to promote endometrial tumorigenesis حسب Taylor, Sarah E., O’Connor, Caitlin M., Wang, Zhizhi, Shen, Guobo, Song, Haichi, Leonard, Daniel, Sangodkar, Jaya, LaVasseur, Corinne, Avril, Stefanie, Waggoner, Steven, Zanotti, Kristine, Armstrong, Amy J., Nagel, Christa, Resnick, Kimberly, Singh, Sareena, Jackson, Mark W., Xu, Wenqing, Haider, Shozeb, DiFeo, Analisa, Narla, Goutham

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Bisphosphonates inactivate human EGFRs to exert antitumor actions حسب Yuen, Tony, Stachnik, Agnes, Iqbal, Jameel, Sgobba, Miriam, Gupta, Yogesh, Lu, Ping, Colaianni, Graziana, Ji, Yaoting, Zhu, Ling-Ling, Kim, Se-Min, Li, Jianhua, Liu, Peng, Izadmehr, Sudeh, Sangodkar, Jaya, Bailey, Jack, Latif, Yathin, Mujtaba, Shiraz, Epstein, Solomon, Davies, Terry F., Bian, Zhuan, Zallone, Alberta, Aggarwal, Aneel K., Haider, Shozeb, New, Maria I., Sun, Li, Narla, Goutham, Zaidi, Mone

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