检索结果 - Richard A. Ward

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  1. 1
    Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations

    Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations 由 Egle Avizienyte, Richard A. Ward, Andrew P. Garner

    出版 2008
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  2. 2
    Resistance to intercompartmental mass transfer limits β2-microglobulin removal by post-dilution hemodiafiltration

    Resistance to intercompartmental mass transfer limits β2-microglobulin removal by post-dilution hemodiafiltration 由 Richard A. Ward, Tom Greene, Beate Hartmann, W. Samtleben

    出版 2006
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  3. 3
    Priming of the Neutrophil Respiratory Burst Involves p38 Mitogen-activated Protein Kinase-dependent Exocytosis of Flavocytochrome b 558-containing Granules

    Priming of the Neutrophil Respiratory Burst Involves p38 Mitogen-activated Protein Kinase-dependent Exocytosis of Flavocytochrome b 558-containing Granules 由 Richard A. Ward, Michio Nakamura, Kenneth R. McLeish

    出版 2000
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  4. 4
    Structural basis of the effect of activating mutations on the EGF receptor

    Structural basis of the effect of activating mutations on the EGF receptor 由 Ioannis Galdadas, Luca Carlino, Richard A. Ward, Samantha Jane Hughes, Shozeb Haider, Francesco Luigi Gervasio

    出版 2021
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  5. 5
    The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M

    The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M 由 Sam Butterworth, Darren A.E. Cross, M. Raymond V. Finlay, Richard A. Ward, Michael J. Waring

    出版 2017
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  6. 6
    ParaMol: A Package for Automatic Parameterization of Molecular Mechanics Force Fields

    ParaMol: A Package for Automatic Parameterization of Molecular Mechanics Force Fields 由 João Morado, Paul N. Mortenson, Marcel L. Verdonk, Richard A. Ward, Jonathan W. Essex, Chris‐Kriton Skylaris

    出版 2021
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  7. 7
    Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

    Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst 由 Silvia M. Uriarte, Madhavi J. Rane, Gregory C. Luerman, Michelle T. Barati, Richard A. Ward, William M. Nauseef, Kenneth R. McLeish

    出版 2011
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  8. 8
    Structural characterization of trypanosomatids kinases: targets to drug discovery

    Structural characterization of trypanosomatids kinases: targets to drug discovery 由 Tatiana de Arruda Campos Brasil de Souza, Daniel Maragno Trindade, Cajsa Tonoli, Camila C. Santos, Richard A. Ward, Arthur Vieira da Silva Oliveira, M. Murakami

    出版 2012
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  9. 9
    Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

    Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III pho... 由 Ružica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard A. Ward, Darren A.E. Cross, Ian G. Ganley, Dario R. Alessi

    出版 2014
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  10. 10
    The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

    The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells 由 Sumaiya Sharmeen, Marko Škrtić, Mahadeo A. Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Sonali B. Fonseca, Hongxiang Sun, Tabitha E. Wood, Richard A. Ward, Mark D. Minden, Robert A. Batey, Alessandro Datti, Jeffrey L. Wrana, Shana O. Kelley, Aaron D. Schimmer

    出版 2010
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  11. 11
    Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily

    Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily 由 Jonathan D.J. Wrigley, Gérald Gavory, Iain Simpson, Marian Preston, Helen Plant, Jenna Bradley, Anne U. Goeppert, Ewelina Rozycka, Gareth M. Davies, Jarrod Walsh, Andrea Valentine, Keeva McClelland, Krzysztofa Ewa Odrzywol, Jonathan Renshaw, Joanna Boros, Jonathan Tart, Lindsey Leach, Thorsten Nowak, Richard A. Ward, Timothy Harrison, David Andrews

    出版 2017
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  12. 12
    Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

    Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions 由 Nicolas Floc’h, Matthew J. Martin, Jonathan W. Riess, Jonathan P. Orme, Anna D. Staniszewska, Ludovic Ménard, Maria Emanuela Cuomo, Daniel O’Neill, Richard A. Ward, M. Raymond V. Finlay, Darren McKerrecher, Mingshan Cheng, Daniel P. Vang, Rebekah A. Burich, James Keck, David R. Gandara, Philip C. Mack, Darren A.E. Cross

    出版 2018
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  13. 13
    AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

    AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer 由 Darren A.E. Cross, Susan Ashton, Serban Ghiorghiu, Cath Eberlein, Caroline A. Nebhan, Paula J. Spitzler, Jonathon P. Orme, M. Raymond V. Finlay, Richard A. Ward, Martine J. Mellor, Gareth Hughes, Amar Rahi, Vivien N. Jacobs, Monica Red Brewer, Eiki Ichihara, Jing Sun, Hailing Jin, Peter Ballard, Katherine Al-Kadhimi, Rachel Rowlinson, Teresa Klinowska, Graham H.P. Richmond, Mireille Cantarini, Dong‐Wan Kim, Malcolm Ranson, William Pao

    出版 2014
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  14. 14
    AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in <i>KRAS</i>-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib

    AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in <i>KRAS</i>-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib 由 Vikki Flemington, Emma Jane Davies, David M. Robinson, Linda C. Sandin, Oona Delpuech, Pei Zhang, Lyndsey Hanson, Paul Farrington, Sigourney Bell, Katarzyna Falenta, Francis D. Gibbons, Nicola Lindsay, Aaron Smith, Joanne Wilson, Karen Roberts, Michael Tonge, Philip Hopcroft, Sophie E. Willis, Martine P. Roudier, Claire Rooney, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Stephen E. Fawell, Clifford D. Jones, Richard A. Ward, Iain Simpson, Sabina Cosulich, J. Elizabeth Pease, Paul D. Smith

    出版 2020
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  15. 15
    Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs

    Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs 由 Nicola Colclough, Kan Chen, Peter Johnström, Nicole Strittmatter, Yumei Yan, Gail L. Wrigley, Magnus Schou, Richard J. A. Goodwin, Katarina Varnäs, Sally J. Adua, Minghui Zhao, Don X. Nguyen, Gareth Maglennon, Peter Barton, James Atkinson, Lin Zhang, Annika Janefeldt, Joanne Wilson, Aaron Smith, Akihiro Takano, Ryosuke Arakawa, Mikhail Kondrashov, Jonas Malmquist, Evgeny Revunov, Ana Vázquez‐Romero, Mohammad Mahdi Moein, Albert D. Windhorst, Natasha A. Karp, M. Raymond V. Finlay, Richard A. Ward, James Yates, Paul D. Smith, Lars Farde, Zack Cheng, Darren A.E. Cross

    出版 2020
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