Search Results - Rapeport, Garth

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  1. 1
    In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice

    In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice by Kimura, Genki, Nakaoki, Takahiro, Colley, Thomas, Rapeport, Garth, Strong, Pete, Ito, Kazuhiro, Kizawa, Yasuo

    Published 2017
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  2. 2
    1335. Safety and Pharmacokinetic Profile of PC786, a Novel Inhibitor of Respiratory Syncytial Virus L-protein Polymerase, in a Single and Multiple-Ascending Dose Study in Healthy Volunteer and Mild Asthmatics

    1335. Safety and Pharmacokinetic Profile of PC786, a Novel Inhibitor of Respiratory Syncytial Virus L-protein Polymerase, in a Single and Multiple-Ascending Dose Study in Healthy V... by Cass, Lindsey, Davis, Amanda, Murray, Alison, Woodward, Kathy, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth

    Published 2018
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  3. 3
    Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway

    Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway by Coates, Matthew S., Alton, Eric W. F. W., Rapeport, Garth W., Davies, Jane C., Ito, Kazuhiro

    Published 2021
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  4. 4
    Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection

    Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection by Colley, Thomas, Sehra, Gurpreet, Daly, Leah, Kimura, Genki, Nakaoki, Takahiro, Nishimoto, Yuki, Kizawa, Yasuo, Strong, Pete, Rapeport, Garth, Ito, Kazuhiro

    Published 2019
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  5. 5
    Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure

    Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure by Thwaites, Ryan S., Coates, Matthew, Ito, Kazuhiro, Ghazaly, Marwa, Feather, Calandra, Abdulla, Farhana, Tunstall, Tanushree, Jain, Pooja, Cass, Lindsey, Rapeport, Garth, Hansel, Trevor T., Nadel, Simon, Openshaw, Peter

    Published 2018
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  6. 6
    In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris

    In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris by Rudramurthy, Shivaprakash M, Colley, Thomas, Abdolrasouli, Alireza, Ashman, Jed, Dhaliwal, Manpreet, Kaur, Harsimran, Armstrong-James, Darius, Strong, Pete, Rapeport, Garth, Schelenz, Silke, Ito, Kazuhiro, Chakrabarti, Arunaloke

    Published 2019
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  7. 7
    Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis

    Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis by Thwaites, Ryan S., Ito, Kazuhiro, Chingono, Jasmine M. S., Coates, Matthew, Jarvis, Hannah C., Tunstall, Tanushree, Anderson-Dring, Lauren, Cass, Lindsey, Rapeport, Garth, Openshaw, Peter J., Nadel, Simon, Hansel, Trevor T.

    Published 2017
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  8. 8
    Late therapeutic intervention with a respiratory syncytial virus L‐protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium

    Late therapeutic intervention with a respiratory syncytial virus L‐protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium by Brookes, Daniel W, Coates, Matthew, Allen, Heather, Daly, Leah, Constant, Samuel, Huang, Song, Hows, Mark, Davis, Amanda, Cass, Lindsey, Ayrton, John, Knowles, Ian, Strong, Pete, Rapeport, Garth, Ito, Kazuhiro

    Published 2018
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  9. 9
    Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus

    Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus by Colley, Thomas, Sharma, Cheshta, Alanio, Alexandre, Kimura, Genki, Daly, Leah, Nakaoki, Takahiro, Nishimoto, Yuki, Bretagne, Stéphane, Kizawa, Yasuo, Strong, Pete, Rapeport, Garth, Ito, Kazuhiro, Meis, Jacques F, Chowdhary, Anuradha

    Published 2019
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  10. 10
    Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

    Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent by Cass, Lindsey, Murray, Alison, Davis, Amanda, Woodward, Kathy, Albayaty, Muna, Ito, Kazuhiro, Strong, Pete, Ayrton, John, Brindley, Charlie, Prosser, Jayne, Murray, John, French, Eddie, Haywood, Phillip, Wallis, Christopher, Rapeport, Garth

    Published 2020
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  11. 11
    Safety and Antiviral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study

    Safety and Antiviral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study by DeVincenzo, John, Cass, Lindsey, Murray, Alison, Woodward, Kathy, Meals, Elizabeth, Coates, Matthew, Daly, Leah, Wheeler, Vicky, Mori, Julie, Brindley, Charlie, Davis, Amanda, McCurdy, Meabh, Ito, Kazuhiro, Murray, Bryan, Strong, Pete, Rapeport, Garth

    Published 2020
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  12. 12
    Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor

    Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor by Coates, Matthew, Brookes, Daniel, Kim, Young-In, Allen, Heather, Fordyce, Euan A. F., Meals, Elizabeth A., Colley, Thomas, Ciana, Claire-Lise, Parra, Guillaume F., Sherbukhin, Vladimir, Stockwell, Jennifer A., Thomas, Jennifer C., Hunt, S. Fraser, Anderson-Dring, Lauren, Onions, Stuart T., Cass, Lindsey, Murray, Peter J., Ito, Kazuhiro, Strong, Pete, DeVincenzo, John P., Rapeport, Garth

    Published 2017
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  13. 13
    In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

    In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection by Colley, Thomas, Alanio, Alexandre, Kelly, Steven L., Sehra, Gurpreet, Kizawa, Yasuo, Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Anderson-Dring, Lauren, Nakaoki, Takahiro, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, Cooke, Michael, Bretagne, Stéphane, King-Underwood, John, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth

    Published 2017
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  14. 14
    In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection

    In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection by Colley, Thomas, Sehra, Gurpreet, Chowdhary, Anuradha, Alanio, Alexandre, Kelly, Steven L., Kizawa, Yasuo, Armstrong-James, Darius, Fisher, Matthew C., Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Nishimoto, Yuki, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, McConville, Matthew, King-Underwood, John, Naylor, Alan, Bretagne, Stéphane, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth

    Published 2018
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  15. 15
    Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 controlled human infection study

    Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 contro... by Jackson, Susan, Marshall, Julia L, Mawer, Andrew, Lopez-Ramon, Raquel, Harris, Stephanie A, Satti, Iman, Hughes, Eileen, Preston-Jones, Hannah, Puig, Ingrid Cabrera, Longet, Stephanie, Tipton, Tom, Laidlaw, Stephen, Doherty, Rebecca Powell, Morrison, Hazel, Mitchell, Robert, Tanner, Rachel, Ateere, Alberta, Stylianou, Elena, Wu, Meng-San, Fredsgaard-Jones, Timothy P W, Breuer, Judith, Rapeport, Garth, Ferreira, Vanessa M, Gleeson, Fergus, Pollard, Andrew J, Carroll, Miles, Catchpole, Andrew, Chiu, Christopher, McShane, Helen

    Published 2024
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