Rezultaty - Rapeport, Garth

In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice od Kimura, Genki, Nakaoki, Takahiro, Colley, Thomas, Rapeport, Garth, Strong, Pete, Ito, Kazuhiro, Kizawa, Yasuo

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1335. Safety and Pharmacokinetic Profile of PC786, a Novel Inhibitor of Respiratory Syncytial Virus L-protein Polymerase, in a Single and Multiple-Ascending Dose Study in Healthy V... od Cass, Lindsey, Davis, Amanda, Murray, Alison, Woodward, Kathy, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth

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Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway od Coates, Matthew S., Alton, Eric W. F. W., Rapeport, Garth W., Davies, Jane C., Ito, Kazuhiro

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Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection od Colley, Thomas, Sehra, Gurpreet, Daly, Leah, Kimura, Genki, Nakaoki, Takahiro, Nishimoto, Yuki, Kizawa, Yasuo, Strong, Pete, Rapeport, Garth, Ito, Kazuhiro

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Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure od Thwaites, Ryan S., Coates, Matthew, Ito, Kazuhiro, Ghazaly, Marwa, Feather, Calandra, Abdulla, Farhana, Tunstall, Tanushree, Jain, Pooja, Cass, Lindsey, Rapeport, Garth, Hansel, Trevor T., Nadel, Simon, Openshaw, Peter

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In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris od Rudramurthy, Shivaprakash M, Colley, Thomas, Abdolrasouli, Alireza, Ashman, Jed, Dhaliwal, Manpreet, Kaur, Harsimran, Armstrong-James, Darius, Strong, Pete, Rapeport, Garth, Schelenz, Silke, Ito, Kazuhiro, Chakrabarti, Arunaloke

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Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis od Thwaites, Ryan S., Ito, Kazuhiro, Chingono, Jasmine M. S., Coates, Matthew, Jarvis, Hannah C., Tunstall, Tanushree, Anderson-Dring, Lauren, Cass, Lindsey, Rapeport, Garth, Openshaw, Peter J., Nadel, Simon, Hansel, Trevor T.

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Late therapeutic intervention with a respiratory syncytial virus L‐protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium od Brookes, Daniel W, Coates, Matthew, Allen, Heather, Daly, Leah, Constant, Samuel, Huang, Song, Hows, Mark, Davis, Amanda, Cass, Lindsey, Ayrton, John, Knowles, Ian, Strong, Pete, Rapeport, Garth, Ito, Kazuhiro

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Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus od Colley, Thomas, Sharma, Cheshta, Alanio, Alexandre, Kimura, Genki, Daly, Leah, Nakaoki, Takahiro, Nishimoto, Yuki, Bretagne, Stéphane, Kizawa, Yasuo, Strong, Pete, Rapeport, Garth, Ito, Kazuhiro, Meis, Jacques F, Chowdhary, Anuradha

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Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent od Cass, Lindsey, Murray, Alison, Davis, Amanda, Woodward, Kathy, Albayaty, Muna, Ito, Kazuhiro, Strong, Pete, Ayrton, John, Brindley, Charlie, Prosser, Jayne, Murray, John, French, Eddie, Haywood, Phillip, Wallis, Christopher, Rapeport, Garth

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Safety and Antiviral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study od DeVincenzo, John, Cass, Lindsey, Murray, Alison, Woodward, Kathy, Meals, Elizabeth, Coates, Matthew, Daly, Leah, Wheeler, Vicky, Mori, Julie, Brindley, Charlie, Davis, Amanda, McCurdy, Meabh, Ito, Kazuhiro, Murray, Bryan, Strong, Pete, Rapeport, Garth

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Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor od Coates, Matthew, Brookes, Daniel, Kim, Young-In, Allen, Heather, Fordyce, Euan A. F., Meals, Elizabeth A., Colley, Thomas, Ciana, Claire-Lise, Parra, Guillaume F., Sherbukhin, Vladimir, Stockwell, Jennifer A., Thomas, Jennifer C., Hunt, S. Fraser, Anderson-Dring, Lauren, Onions, Stuart T., Cass, Lindsey, Murray, Peter J., Ito, Kazuhiro, Strong, Pete, DeVincenzo, John P., Rapeport, Garth

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In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection od Colley, Thomas, Alanio, Alexandre, Kelly, Steven L., Sehra, Gurpreet, Kizawa, Yasuo, Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Anderson-Dring, Lauren, Nakaoki, Takahiro, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, Cooke, Michael, Bretagne, Stéphane, King-Underwood, John, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth

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In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection od Colley, Thomas, Sehra, Gurpreet, Chowdhary, Anuradha, Alanio, Alexandre, Kelly, Steven L., Kizawa, Yasuo, Armstrong-James, Darius, Fisher, Matthew C., Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Nishimoto, Yuki, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, McConville, Matthew, King-Underwood, John, Naylor, Alan, Bretagne, Stéphane, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth

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Safety, tolerability, viral kinetics, and immune correlates of protection in healthy, seropositive UK adults inoculated with SARS-CoV-2: a single-centre, open-label, phase 1 contro... od Jackson, Susan, Marshall, Julia L, Mawer, Andrew, Lopez-Ramon, Raquel, Harris, Stephanie A, Satti, Iman, Hughes, Eileen, Preston-Jones, Hannah, Puig, Ingrid Cabrera, Longet, Stephanie, Tipton, Tom, Laidlaw, Stephen, Doherty, Rebecca Powell, Morrison, Hazel, Mitchell, Robert, Tanner, Rachel, Ateere, Alberta, Stylianou, Elena, Wu, Meng-San, Fredsgaard-Jones, Timothy P W, Breuer, Judith, Rapeport, Garth, Ferreira, Vanessa M, Gleeson, Fergus, Pollard, Andrew J, Carroll, Miles, Catchpole, Andrew, Chiu, Christopher, McShane, Helen

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