Ohcanbohtosat - Qiu, Huawei

Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer Dahkki Yu, Xiangjing, Liu, Jie, Qiu, Huawei, Hao, Huiting, Zhu, Jinhong, Peng, Shiyun

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells Dahkki Zhu, Hao, Qiu, Huawei, Yoon, Hae-Won Patricia, Huang, Shuning, Bunn, H. Franklin

Viečča ollesdeavstta Viečča ollesdeavstta

Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease Dahkki Zhou, Yan-Feng, Metcalf, Matthew C., Garman, Scott C., Edmunds, Tim, Qiu, Huawei, Wei, Ronnie R.

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGFβ1 antibody Dahkki Lord, Dana M., Bird, Julie J., Honey, Denise M., Best, Annie, Park, Anna, Wei, Ronnie R., Qiu, Huawei

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Impact of cysteine variants on the structure, activity, and stability of recombinant human α-galactosidase A Dahkki Qiu, Huawei, Honey, Denise M, Kingsbury, Jonathan S, Park, Anna, Boudanova, Ekaterina, Wei, Ronnie R, Pan, Clark Q, Edmunds, Tim

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

X-ray and Biochemical Analysis of N370S Mutant Human Acid β-Glucosidase Dahkki Wei, Ronnie R., Hughes, Heather, Boucher, Susan, Bird, Julie J., Guziewicz, Nicholas, Van Patten, Scott M., Qiu, Huawei, Pan, Clark Qun, Edmunds, Tim

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues Dahkki Zhou, Qun, Kyazike, Josephine, Boudanova, Ekaterina, Drzyzga, Michael, Honey, Denise, Cost, Robert, Hou, Lihui, Duffieux, Francis, Brun, Marie-Priscille, Park, Anna, Qiu, Huawei

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

A Bispecific Protein Capable of Engaging CTLA-4 and MHCII Protects Non-Obese Diabetic Mice from Autoimmune Diabetes Dahkki Zhao, Hongmei, Karman, Jozsef, Jiang, Ji-Lei, Zhang, Jinhua, Gumlaw, Nathan, Lydon, John, Zhou, Qun, Qiu, Huawei, Jiang, Canwen, Cheng, Seng H., Zhu, Yunxiang

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life Dahkki Mackness, Brian C., Jaworski, Julie A., Boudanova, Ekaterina, Park, Anna, Valente, Delphine, Mauriac, Christine, Pasquier, Olivier, Schmidt, Thorsten, Kabiri, Mostafa, Kandira, Abdullah, Radošević, Katarina, Qiu, Huawei

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models Dahkki Valente, Delphine, Mauriac, Christine, Schmidt, Thorsten, Focken, Ingo, Beninga, Jochen, Mackness, Brian, Qiu, Huawei, Vicat, Pascale, Kandira, Abdullah, Radošević, Katarina, Rao, Srini, Darbyshire, John, Kabiri, Mostafa

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Engineering an anti-CD52 antibody for enhanced deamidation stability Dahkki Qiu, Huawei, Wei, Ronnie, Jaworski, Julie, Boudanova, Ekaterina, Hughes, Heather, VanPatten, Scott, Lund, Anders, Day, Jaime, Zhou, Yanfeng, McSherry, Tracey, Pan, Clark Q., Sendak, Rebecca

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Engineered Fc-glycosylation switch to eliminate antibody effector function Dahkki Zhou, Qun, Jaworski, Julie, Zhou, Yanfeng, Valente, Delphine, Cotton, Joanne, Honey, Denise, Boudanova, Ekaterina, Beninga, Jochen, Rao, Ercole, Wei, Ronnie, Mauriac, Christine, Pan, Clark, Park, Anna, Qiu, Huawei

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Engineering Aglycosylated IgG Variants with Wild-type or Improved Binding Affinity to Human Fc gamma RIIA and Fc gamma RIIIAs Dahkki Chen, Tiffany F., Sazinsky, Stephen L., Houde, Damian, DiLillo, David J., Bird, Julie, Li, Kevin K., Cheng, George T., Qiu, Huawei, Engen, John R., Ravetch, Jeffrey V., Wittrup, K. Dane

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting... Dahkki Qiu, Yu, Stegalkina, Svetlana, Zhang, Jianxin, Boudanova, Ekaterina, Park, Anna, Zhou, Yanfeng, Prabakaran, Ponraj, Pougatcheva, Svetlana, Ustyugova, Irina V., Vogel, Thorsten U., Mundle, Sophia T., Oomen, Ray, Delagrave, Simon, Ross, Ted M., Kleanthous, Harry, Qiu, Huawei

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms Dahkki Stefano, James E., Lord, Dana M., Zhou, Yanfeng, Jaworski, Julie, Hopke, Joern, Travaline, Tara, Zhang, Ningning, Wong, Karen, Lennon, Amanda, He, Timothy, Bric-Furlong, Eva, Cherrie, Cornishia, Magnay, Tristan, Remy, Elisabeth, Brondyk, William, Qiu, Huawei, Radošević, Katarina

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions Dahkki Moulin, Aaron, Mathieu, Magali, Lawrence, Catherine, Bigelow, Russell, Levine, Mark, Hamel, Christine, Marquette, Jean-Piere, Le Parc, Josiane, Loux, Christophe, Ferrari, Paul, Capdevila, Cecile, Dumas, Jacques, Dumas, Bruno, Rak, Alexey, Bird, Julie, Qiu, Huawei, Pan, Clark Q, Edmunds, Tim, Wei, Ronnie R

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta

biAb Mediated Restoration of the Linkage between Dystroglycan and Laminin-211 as a Therapeutic Approach for α-Dystroglycanopathies Dahkki Gumlaw, Nathan, Sevigny, Leila M., Zhao, Hongmei, Luo, Zhengyu, Bangari, Dinesh S., Masterjohn, Elizabeth, Chen, Yangde, McDonald, Barbara, Magnay, Maureen, Travaline, Tara, Yoshida-Moriguchi, Takako, Fan, Wei, Reczek, David, Stefano, James E., Qiu, Huawei, Beil, Christian, Lange, Christian, Rao, Ercole, Lukason, Michael, Barry, Elizabeth, Brondyk, William H., Zhu, Yunxiang, Cheng, Seng H.

Viečča ollesdeavstta Viečča ollesdeavstta Viečča ollesdeavstta