Výsledky vyhledávání - Philipp Sievers

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  1. 1
    Clinical implementation of integrated molecular‐morphologic risk prediction for meningioma

    Clinical implementation of integrated molecular‐morphologic risk prediction for meningioma Autor Thomas Hielscher, Martin Sill, Philipp Sievers, Damian Stichel, Sebastian Brandner, David Jones, Andreas von Deimling, Felix Sahm, Sybren L. N. Maas

    Vydáno 2022
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  2. 2
    Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice

    Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice Autor Frank Szulzewsky, Sonali Arora, Aleena Arakaki, Philipp Sievers, Damian A. Almiron Bonnin, Patrick J. Paddison, Felix Sahm, Patrick J. Cimino, Taranjit S. Gujral, Eric C. Holland

    Vydáno 2022
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  3. 3
    Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling

    Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling Autor Konstantin Okonechnikov, David R. Ghasemi, Daniel Schrimpf, Svenja Tonn, Martin Mynarek, Jan Köster, Till Milde, Tuyu Zheng, Philipp Sievers, Felix Sahm, David Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Kristian W. Pajtler, Andrey Korshunov

    Vydáno 2025
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  4. 4
    Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

    Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation Autor Andrey Korshunov, Konstantin Okonechnikov, Felix Schmitt-Hoffner, Marina Ryzhova, Felix Sahm, Damian Stichel, Daniel Schrimpf, David Reuß, Philipp Sievers, Abigail K. Suwala, Э. В. Кумирова, Olga Zheludkova, Andrey Golanov, David Jones, Stefan M. Pfister, Marcel Kool, Andreas von Deimling

    Vydáno 2021
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  5. 5
    Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042

    Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular an... Autor Sybren L. N. Maas, Philipp Sievers, Damien C. Weber, Michael Weller, Martin J. van den Bent, Maximilian J. Mair, Johan M. Kros, Fransesca Carparrotti, Andreas von Deimling, V. Salvador, Saskia M. Peerdeman, José Casas-Martín, Thierry Gorlia, Felix Sahm, Matthias Preusser

    Vydáno 2023
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  6. 6
    Response to trametinib treatment in progressive pediatric low-grade glioma patients

    Response to trametinib treatment in progressive pediatric low-grade glioma patients Autor Florian Selt, Cornelis M. van Tilburg, Brigitte Bison, Philipp Sievers, Inga Harting, Jonas Ecker, Kristian W. Pajtler, Felix Sahm, Annabelle Bahr, Michèle Simon, David Jones, Lennart Well, Victor‐Felix Mautner, David Capper, Pablo Hernáiz Driever, Astrid Gnekow, Stefan M. Pfister, Olaf Witt, Till Milde

    Vydáno 2020
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  7. 7
    Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas

    Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas Autor Elmar Kirches, Felix Sahm, Andrey Korshunov, Christina Bluecher, Natalie Waldt, Siegfried Kropf, Daniel Schrimpf, Philipp Sievers, Damian Stichel, Ulrich Schüller, Jens Schittenhelm, Markus J. Riemenschneider, Matthias A. Karajannis, Arie Perry, Torsten Pietsch, Svenja Boekhoff, David Capper, Katja Beck, Nagarajan Paramasivam, Matthias Schlesner, Priscilla K. Brastianos, Hermann L. Müller, Stefan M. Pfister, Christian Mawrin

    Vydáno 2021
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  8. 8
    Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

    Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience Autor David Capper, Damian Stichel, Felix Sahm, David Jones, Daniel Schrimpf, Martin Sill, Simone Schmid, Volker Hovestadt, David Reuß, Christian Koelsche, Annekathrin Reinhardt, Annika K. Wefers, Kristin Huang, Philipp Sievers, Azadeh Ebrahimi, Anne Schöler, Daniel Teichmann, Arend Koch, Daniel Hänggi, Andreas Unterberg, Michael Platten, Wolfgang Wick, Olaf Witt, Till Milde, Andrey Korshunov, Stefan M. Pfister, Andreas von Deimling

    Vydáno 2018
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  9. 9
    CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

    CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas Autor Philipp Sievers, Thomas Hielscher, Daniel Schrimpf, Damian Stichel, David Reuß, Anna S. Berghoff, Marian C. Neidert, Hans‐Georg Wirsching, Christian Mawrin, Ralf Ketter, Werner Paulus, Guido Reifenberger, Katrin Lamszus, Manfred Westphal, Nima Etminan, Miriam Ratliff, Christel Herold‐Mende, Stefan M. Pfister, David Jones, Michael Weller, Patrick N. Harter, Wolfgang Wick, Matthias Preusser, Andreas von Deimling, Felix Sahm

    Vydáno 2020
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  10. 10
    Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma

    Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma Autor Verena Panitz, Saša Končarević, Ahmed Sadik, Dennis Friedel, Tobias Bausbacher, Saskia Trump, Vadim Farztdinov, Sandra Schulz, Philipp Sievers, S. Schmidt, Ina Jürgenson, Stephan Jung, Karsten Kuhn, Irada Pflüger, Suraj Sharma, Antje Wick, Pauline Pfänder, Stefan Selzer, Philipp Kickingereder, Felix Sahm, Andreas von Deimling, Ines Heiland, Carsten Hopf, Peter Schulz‐Knappe, Ian Pike, Michael Platten, Wolfgang Wick, Christiane A. Opitz

    Vydáno 2021
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  11. 11
    Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study

    Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study Autor Areeba Patel, Helin Dogan, Alexander Payne, Elena Krause, Philipp Sievers, Natalie Schoebe, Daniel Schrimpf, Christina Blume, Damian Stichel, Nadine Holmes, Philipp Euskirchen, Jürgen Hench, Stephan Frank, Violaine Rosenstiel-Goidts, Miriam Ratliff, Nima Etminan, Andreas Unterberg, Christoph Dieterich, Christel Herold‐Mende, Stefan M. Pfister, Wolfgang Wick, Matthew Loose, Andreas von Deimling, Martin Sill, David Jones, Matthias Schlesner, Felix Sahm

    Vydáno 2022
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  12. 12
    Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome

    Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome Autor H. Nayanga Thirimanne, Damian Almiron-Bonnin, Nicholas Nuechterlein, Sonali Arora, Matt Jensen, Carolina A. Parada, Chengxiang Qiu, Frank Szulzewsky, Collin W. English, William Chen, Philipp Sievers, Farshad Nassiri, Justin Z. Wang, Tiemo J. Klisch, Kenneth D. Aldape, Akash J. Patel, Patrick J. Cimino, Gelareh Zadeh, Felix Sahm, David R. Raleigh, Jay Shendure, Manuel Ferreira, Eric C. Holland

    Vydáno 2024
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  13. 13
    BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma

    BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma Autor Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alcon, Simone Schmid, Heike Peterziel, Jessica W. Tsai, Romain Guiho, Juan Pedro Martı́nez-Barberá, Stefan Pusch, Jing Deng, Yifan Zhai, Cornelis M. van Tilburg, Martin U Schuhman, Ahmed El Damaty, Pratiti Bandopadhayay, Christel Herold‐Mende, Andreas von Deimling, Stefan M. Pfister, Joan Montero, David Capper, Ina Oehme, Felix Sahm, David Jones, Olaf Witt, Till Milde

    Vydáno 2022
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  14. 14
    Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics

    Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics Autor Michael Ritter, Christina Blume, Yiheng Tang, Areeba Patel, Bhuvic Patel, Natalie Berghaus, Jasim Kada Benotmane, Jan Kueckelhaus, Yahaya A Yabo, Junyi Zhang, Elena Grabis, Giulia Villa, David Niklas Zimmer, Amir Khriesh, Philipp Sievers, Zaira Seferbekova, Felix Hinz, Vidhya M. Ravi, Marcel Seiz‐Rosenhagen, Miriam Ratliff, Christel Herold‐Mende, Oliver Schnell, Jürgen Beck, Wolfgang Wick, Andreas von Deimling, Moritz Gerstung, Dieter Henrik Heiland, Felix Sahm

    Vydáno 2025
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  15. 15
    A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of <i>EGFR</i>

    A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of <i>EGFR</i> Autor Philipp Sievers, Martin Sill, Daniel Schrimpf, Damian Stichel, David Reuß, Dominik Sturm, Jürgen Hench, Stephan Frank, Lenka Krsková, Aleš Vícha, Michal Zápotocký, Brigitte Bison, David Castel, Jacques Grill, Marie‐Anne Debily, Patrick N. Harter, Matija Snuderl, Christof M. Kramm, Guido Reifenberger, Andrey Korshunov, Nada Jabado, Pieter Wesseling, Wolfgang Wick, David A. Solomon, Arie Perry, Thomas S. Jacques, Chris Jones, Olaf Witt, Stefan M. Pfister, Andreas von Deimling, David Jones, Felix Sahm

    Vydáno 2020
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  16. 16
    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1 Autor Ling Hai, Dirk C. Hoffmann, Robin J. Wagener, Daniel Domínguez Azorín, David Hausmann, Ruifan Xie, Magnus-Carsten Huppertz, Julien Hiblot, Philipp Sievers, Sophie Heuer, Jakob Ito, Gina Cebulla, Alexandros Kourtesakis, Leon D. Kaulen, Miriam Ratliff, Henriette Mandelbaum, Erik Jung, Ammar Jabali, Sandra Horschitz, Kati Ernst, Denise Reibold, Uwe Warnken, Varun Venkataramani, Rainer Will, Mario L. Suvà, Christel Herold‐Mende, Felix Sahm, Frank Winkler, Matthias Schlesner, Wolfgang Wick, Tobias Keßler

    Vydáno 2024
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  17. 17
    Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions

    Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions Autor Arnault Tauziède‐Espariat, Aurore Siegfried, Yvan Nicaise, Thomas Kergrohen, Philipp Sievers, Alexandre Vasiljevic, Alexandre Roux, Edouard Dezamis, Chiara Benevello, Marie‐Christine Machet, Sophie Michalak, Chloé Puiseux, Francisco Llamas‐Gutierrez, Pierre Leblond, Franck Bourdeaut, Jacques Grill, Christelle Dufour, Léa Guerrini‐Rousseau, Samuel Abbou, Volodia Dangouloff‐Ros, Nathalie Boddaert, Raphaël Saffroy, Lauren Hasty, Ellen Wahler, Mélanie Pagès, Felipe Andreiuolo, Emmanuèle Lechapt, Fabrice Chrétien, Thomas Blauwblomme, Kévin Beccaria, Johan Pallud, Stéphanie Puget, Emmanuelle Uro‐Coste, Pascale Varlet

    Vydáno 2021
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  18. 18
    Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1

    Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1 Autor Philipp Sievers, Romain Appay, Daniel Schrimpf, Damian Stichel, David Reuß, Annika K. Wefers, Annekathrin Reinhardt, Roland Coras, Viktoria Ruf, Simone Schmid, Karin de Stricker, Henning B. Boldt, Bjarne Winther Kristensen, Jeanette Krogh Petersen, Benedicte Parm Ulhøi, Maria Gardberg, Eleonora Aronica, Martin Hasselblatt, Wolfgang Brück, Franck Bielle, Karima Mokhtari, Benoît Lhermitte, Wolfgang Wick, Christel Herold‐Mende, Daniel Hänggi, Sebastian Brandner, Felice Giangaspero, David Capper, Elisabeth J. Rushing, Pieter Wesseling, Stefan M. Pfister, Dominique Figarella‐Branger, Andreas von Deimling, Felix Sahm, David Jones

    Vydáno 2019
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  19. 19
    Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

    Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis Autor Abigail K. Suwala, Damian Stichel, Daniel Schrimpf, Matthias Kloor, Annika K. Wefers, Annekathrin Reinhardt, Sybren L. N. Maas, Christian P. Kratz, Leonille Schweizer, Martin Hasselblatt, Matija Snuderl, Malak Abedalthagafi, Zied Abdullaev, Camelia M. Monoranu, Markus Bergmann, Arnulf Pekrun, Christian F. Freyschlag, Eleonora Aronica, Christof M. Kramm, Felix Hinz, Philipp Sievers, Andrey Korshunov, Marcel Kool, Stefan M. Pfister, Dominik Sturm, David Jones, Wolfgang Wick, Andreas Unterberg, Christian Hartmann, Andrew Dodgshun, Uri Tabori, Pieter Wesseling, Felix Sahm, Andreas von Deimling, David Reuß

    Vydáno 2020
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  20. 20
    Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1

    Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1 Autor Philipp Sievers, Martin Sill, Christina Blume, Arnault Tauziède‐Espariat, Daniel Schrimpf, Damian Stichel, David Reuß, Helin Dogan, Christian Hartmann, Christian Mawrin, Martin Hasselblatt, Walter Stummer, Uta Schick, Jürgen Hench, Stephan Frank, Ralf Ketter, Leonille Schweizer, Jens Schittenhelm, Stéphanie Puget, Sebastian Brandner, Zane Jaunmuktane, Benno Küsters, Zied Abdullaev, Melike Pekmezci, Matija Snuderl, Miriam Ratliff, Christel Herold‐Mende, Andreas Unterberg, Kenneth Aldape, David W. Ellison, Pieter Wesseling, Guido Reifenberger, Wolfgang Wick, Arie Perry, Pascale Varlet, Stefan M. Pfister, David Jones, Andreas von Deimling, Felix Sahm

    Vydáno 2020
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