Výsledky vyhledávání - Philip B. Verghese

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  1. 1
    Apolipoprotein E in Alzheimer's disease and other neurological disorders

    Apolipoprotein E in Alzheimer's disease and other neurological disorders Autor Philip B. Verghese, Joseph M. Castellano, David M. Holtzman

    Vydáno 2011
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  2. 2
    Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

    Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation Autor Ellen Hubin, Philip B. Verghese, Nico van Nuland, Kerensa Broersen

    Vydáno 2019
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  3. 3
    The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

    The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation Autor Kanchan Garai, Philip B. Verghese, Berevan Baban, David M. Holtzman, Carl Frieden

    Vydáno 2014
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  4. 4
    Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

    Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes Autor Jacob M. Basak, Philip B. Verghese, Hyejin Yoon, Jungsu Kim, David M. Holtzman

    Vydáno 2012
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  5. 5
    Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis

    Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis Autor Dick Terwel, Knut R. Steffensen, Philip B. Verghese, Markus P. Kummer, Jan-Ακε Gustafsson, David M. Holtzman, Michael T. Heneka

    Vydáno 2011
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  6. 6
    ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

    ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions Autor Philip B. Verghese, Joseph M. Castellano, Kanchan Garai, Yinong Wang, Hong Jiang, Aarti R. Shah, Guojun Bu, Carl Frieden, David M. Holtzman

    Vydáno 2013
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  7. 7
    A randomized controlled study to evaluate the effect of bexarotene on amyloid‐β and apolipoprotein E metabolism in healthy subjects

    A randomized controlled study to evaluate the effect of bexarotene on amyloid‐β and apolipoprotein E metabolism in healthy subjects Autor Kaushik Ghosal, Michael Haag, Philip B. Verghese, Tim West, T VEENSTRA, Joel B. Braunstein, Randall J. Bateman, David M. Holtzman, Gary E. Landreth

    Vydáno 2016
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  8. 8
    Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

    Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes Autor Won‐Suk Chung, Philip B. Verghese, Chandrani Chakraborty, J. Keith Joung, Bradley T. Hyman, Jason D. Ulrich, David M. Holtzman, Ben A. Barres

    Vydáno 2016
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  9. 9
    Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

    Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis Autor Jungsu Kim, Adam E. M. Eltorai, Hong Jiang, Fan Liao, Philip B. Verghese, Jaekwang Kim, Floy R. Stewart, Jacob M. Basak, David M. Holtzman

    Vydáno 2012
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  10. 10
    Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

    Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Autor Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman, Berislav V. Zloković

    Vydáno 2018
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  11. 11
    Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

    Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death Autor Philip B. Verghese, Yo Sasaki, Donghan M. Yang, Floy R. Stewart, Fatima Sabar, Mary Beth Finn, Christine M. Wroge, Steven Mennerick, Jeffrey J. Neil, Jeffrey Milbrandt, David M. Holtzman

    Vydáno 2011
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  12. 12
    Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

    Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation Autor Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard, Rashid Deane

    Vydáno 2016
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  13. 13
    Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

    Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis Autor Joseph M. Castellano, Rashid Deane, Andrew J. Gottesdiener, Philip B. Verghese, Floy R. Stewart, Tim West, Andrew C. Paoletti, Tristan Kasper, Ronald B. DeMattos, Berislav V. Zloković, David M. Holtzman

    Vydáno 2012
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  14. 14
    In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

    In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis Autor Jason D. Ulrich, Jack M. Burchett, Jessica L. Restivo, Dorothy R. Schuler, Philip B. Verghese, Thomas E. Mahan, Gary E. Landreth, Joseph M. Castellano, Hong Jiang, John R. Cirrito, David M. Holtzman

    Vydáno 2013
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  15. 15
    Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

    Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline Autor Shan Liu, Shin-Ae Park, Garrett Allington, Frances Prelli, Yanjie Sun, Mitchell Martá-Ariza, Henrieta Scholtzova, Goutam Biswas, Bernard J. Treves Brown, Philip B. Verghese, Pankaj Mehta, Yong-Uk Kwon, Thomas Wısnıewskı

    Vydáno 2017
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  16. 16
    The PrecivityAD™ test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis

    The PrecivityAD™ test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis Autor Kristopher M. Kirmess, Matthew R. Meyer, Mary S. Holubasch, S Knapik, Yan Hu, Erin N. Jackson, Scott E. Harpstrite, Philip B. Verghese, Tim West, I. Fogelman, Joel B. Braunstein, Kevin E. Yarasheski, John H. Contois

    Vydáno 2021
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  17. 17
    Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study

    Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study Autor Mark Monane, Demetrius M. Maraganore, Robert G. Carlile, Kim Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

    Vydáno 2025
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  18. 18
    A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis

    A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysi... Autor Tim West, Kristopher M. Kirmess, Matthew R. Meyer, Mary S. Holubasch, S Knapik, Yan Hu, John H. Contois, Erin N. Jackson, Scott E. Harpstrite, Randall J. Bateman, David M. Holtzman, Philip B. Verghese, I. Fogelman, Joel B. Braunstein, Kevin E. Yarasheski

    Vydáno 2021
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  19. 19
    microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain

    microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain Autor Jaekwang Kim, Hyejin Yoon, Takahiro Horie, Jack M. Burchett, Jessica L. Restivo, Noemí Rotllán, Cristina M. Ramírez, Philip B. Verghese, Masafumi Ihara, Hyang-Sook Hoe, Christine Esau, Carlos Fernández‐Hernando, David M. Holtzman, John R. Cirrito, Koh Ono, Jungsu Kim

    Vydáno 2015
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  20. 20
    Comparison of plasma and <scp>CSF</scp> biomarkers in predicting cognitive decline

    Comparison of plasma and <scp>CSF</scp> biomarkers in predicting cognitive decline Autor Andrew J. Aschenbrenner, Yan Li, Rachel L. Henson, Katherine Volluz, Jason Hassenstab, Philip B. Verghese, Tim West, Matthew R. Meyer, Kristopher M. Kirmess, Anne M. Fagan, Chengjie Xiong, David M. Holtzman, John C. Morris, Randall J. Bateman, Suzanne E. Schindler

    Vydáno 2022
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