Resultats de la cerca - Peter G. Miller

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  1. 1
    Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade

    Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade per Peter G. Miller, Christopher J. Gibson, Arnav Mehta, Adam S. Sperling, Dennie T. Frederick, Michael P. Manos, Benchun Miao, Nir Hacohen, F. Stephen Hodi, Genevieve M. Boland, Benjamin L. Ebert

    Publicat 2020
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  2. 2
    A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

    A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors per Rajiv S. Jumani, Muhammad M. Hasan, Erin E. Stebbins, Liam Donnelly, Peter G. Miller, Connor Klopfer, Kovi Bessoff, José E. Teixeira, Melissa S. Love, Case W. McNamara, Christopher D. Huston

    Publicat 2019
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  3. 3
    Gene Sets Identified with Oncogene Cooperativity Analysis Regulate In Vivo Growth and Survival of Leukemia Stem Cells

    Gene Sets Identified with Oncogene Cooperativity Analysis Regulate In Vivo Growth and Survival of Leukemia Stem Cells per John M. Ashton, Marlene Balys, Sarah J. Neering, Duane C. Hassane, Glenn S. Cowley, David E. Root, Peter G. Miller, Benjamin L. Ebert, Helene R. McMurray, Hartmut Land, Craig T. Jordan

    Publicat 2012
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  4. 4
    A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box

    A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box per Rajiv S. Jumani, Kovi Bessoff, Melissa S. Love, Peter G. Miller, Erin E. Stebbins, José E. Teixeira, Mary Ann Campbell, Marvin J. Meyers, Jennifer A. Zambriski, Vanessa Núñez, Ashley K. Woods, Case W. McNamara, Christopher D. Huston

    Publicat 2018
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  5. 5
    Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy

    Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy per Peter G. Miller, Adam S. Sperling, Elliott J. Brea, Mark B. Leick, Geoffrey Fell, Max Jan, Satyen H. Gohil, Yu‐Tzu Tai, Nikhil C. Munshi, Catherine J. Wu, Donna Neuberg, Marcela V. Maus, Caron A. Jacobson, Christopher J. Gibson, Benjamin L. Ebert

    Publicat 2021
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  6. 6
    Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

    Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis per Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Mahmudul Hasan, Peter G. Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiří Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric E. Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston

    Publicat 2019
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  7. 7
    Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

    Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis per Inga Hofmann, Elizabeth H. Stover, Dana E. Cullen, Junhao Mao, Kelly Morgan, Benjamin H. Lee, Michael G. Kharas, Peter G. Miller, Melanie Cornejo, Rachel Okabe, Scott A. Armstrong, Nico Ghilardi, Stephen E. Gould, Frédéric J. de Sauvage, Andrew P. McMahon, D. Gary Gilliland

    Publicat 2009
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  8. 8
    Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

    Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia per Marcus Järås, Peter G. Miller, Lisa P. Chu, Rishi V. Puram, Emma C. Fink, Rebekka K. Schneider, Fátima Al‐Shahrour, Pablo Peña‐Martínez, Lawrence J. Breyfogle, Kimberly A. Hartwell, Marie McConkey, Glenn S. Cowley, David E. Root, Michael G. Kharas, Ann Mullally, Benjamin L. Ebert

    Publicat 2014
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  9. 9
    PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

    PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells per Josephine Kahn, Peter G. Miller, Alexander J. Silver, Rob S. Sellar, Shruti Bhatt, Christopher J. Gibson, Marie McConkey, Dylan N. Adams, Brenton G. Mar, Philipp Mertins, Shaunt Fereshetian, Karsten Krug, Haoling Zhu, Anthony Letai, Steven A. Carr, John G. Doench, Siddhartha Jaiswal, Benjamin L. Ebert

    Publicat 2018
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  10. 10
    An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis

    An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis per Adi Zoref‐Lorenz, Jun Murakami, Liron Hofstetter, Swaminathan P. Iyer, Ahmad S. Alotaibi, Shehab Mohamed, Peter G. Miller, Elad Guber, Shiri Weinstein, Joanne Yacobovich, Sarah Nikiforow, Benjamin L. Ebert, Adam Lane, Oren Pasvolsky, Pia Raanani, Arnon Nagler, Nancy Berliner, Naval Daver, Martin Ellis, Michael B. Jordan

    Publicat 2021
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  11. 11
    Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

    Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML per Rishi V. Puram, Monika S. Kowalczyk, Carl G. de Boer, Rebekka K. Schneider, Peter G. Miller, Marie McConkey, Zuzana Tóthová, Héctor Tejero, Dirk Heckl, Marcus Järås, Michelle C. Chen, Hubo Li, Alfred Tamayo, Glenn S. Cowley, Orit Rozenblatt–Rosen, Fátima Al‐Shahrour, Aviv Regev, Benjamin L. Ebert

    Publicat 2016
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  12. 12
    Small-molecule-induced polymerization triggers degradation of BCL6

    Small-molecule-induced polymerization triggers degradation of BCL6 per Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel, Lena Nitsch, Shourya S. Roy Burman, Cristina Di Genua, Katherine A. Donovan, Adam S. Sperling, Moritz Hunkeler, Jonathan M. Tsai, Rohan Sharma, Andrew A. Guirguis, Charles Zou, Priya Chudasama, Jessica A. Gasser, Peter G. Miller, Claudia Scholl, Stefan Fröhling, Radosław P. Nowak, Eric S. Fischer, Benjamin L. Ebert

    Publicat 2020
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  13. 13
    Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs

    Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs per Adam S. Sperling, Michael Burgess, Hasmik Keshishian, Jessica A. Gasser, Shruti Bhatt, Max Jan, Mikołaj Słabicki, Rob S. Sellar, Emma C. Fink, Peter G. Miller, Brian Liddicoat, Quinlan Sievers, Rohan Sharma, Dylan N. Adams, Elyse A. Olesinski, Mariateresa Fulciniti, Namrata D. Udeshi, Eric Kuhn, Anthony Letai, Nikhil C. Munshi, Steven A. Carr, Benjamin L. Ebert

    Publicat 2019
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  14. 14
    PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

    PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy per Peter G. Miller, Adam S. Sperling, Christina Mayerhofer, Marie McConkey, Jana M. Ellegast, Carmen Da Silva, Drew N. Cohen, Chuqi Wang, Azeem Sharda, Ni Yan, Subha Saha, Cameron Schluter, Ilexa Schechter, Mikołaj Słabicki, Brittany Sandoval, Josephine Kahn, Steffen Boettcher, Christopher J. Gibson, David T. Scadden, Kimberly Stegmaier, Shruti Bhatt, R. Coleman Lindsley, Benjamin L. Ebert

    Publicat 2023
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  15. 15
    A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies

    A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies per Steffen Boettcher, Peter G. Miller, Rohan Sharma, Marie McConkey, Matthew Leventhal, Andrei V. Krivtsov, Andrew O. Giacomelli, Waihay J. Wong, Jesi Kim, Sherry Chao, Kari J. Kurppa, Xiaoping Yang, Kirsten Milenkowic, Federica Piccioni, David E. Root, Frank G. Rücker, Yael Flamand, Donna Neuberg, R. Coleman Lindsley, Pasi A. Jänne, William C. Hahn, Tyler Jacks, Hartmut Döhner, Scott A. Armstrong, Benjamin L. Ebert

    Publicat 2019
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  16. 16
    Bicyclic azetidines kill the diarrheal pathogen <i>Cryptosporidium</i> in mice by inhibiting parasite phenylalanyl-tRNA synthetase

    Bicyclic azetidines kill the diarrheal pathogen <i>Cryptosporidium</i> in mice by inhibiting parasite phenylalanyl-tRNA synthetase per Sumiti Vinayak, Rajiv S. Jumani, Peter G. Miller, Muhammad M. Hasan, Briana I. McLeod, Jayesh Tandel, Erin E. Stebbins, José E. Teixeira, Julien Borrel, Arthur Gonse, Mingliang Zhang, Xianshui Yu, Amy K. Wernimont, Chris Walpole, Sean Eckley, Melissa S. Love, Case W. McNamara, Manmohan Sharma, Amit Sharma, Christina Scherer, Nobutaka Kato, Stuart L. Schreiber, Bruno Melillo, Boris Striepen, Christopher D. Huston, Eamon Comer

    Publicat 2020
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  17. 17
    <i>TET2</i>-mutant clonal hematopoiesis and risk of gout

    <i>TET2</i>-mutant clonal hematopoiesis and risk of gout per Mridul Agrawal, Abhishek Niroula, Pierre Cunin, Marie McConkey, Veronica Shkolnik, Peter G. Kim, Waihay J. Wong, Lachelle D. Weeks, Amy Lin, Peter G. Miller, Christopher J. Gibson, Aswin Sekar, Inga‐Marie Schaefer, Donna Neuberg, Richard M. Stone, Alexander G. Bick, Md Mesbah Uddin, Gabriel K. Griffin, Siddhartha Jaiswal, Pradeep Natarajan, Peter A. Nigrović, Deepak A. Rao, Benjamin L. Ebert

    Publicat 2022
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  18. 18
    Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non–Small Cell Lung Cancer Using a Clinicogenomic Database

    Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non–Small Cell Lung Cancer Using a Clinicogenomic Database per Gaurav Singal, Peter G. Miller, Vineeta Agarwala, Gerald Li, Gaurav Kaushik, Daniel Backenroth, Anala Gossai, Garrett M. Frampton, Aracelis Z. Torres, Erik Lehnert, David Bourque, Claire O’Connell, Bryan Bowser, Thomas Caron, Ezra Baydur, Kathi Seidl-Rathkopf, Ivan Ivanov, Garrett Alpha-Cobb, Ameet Guria, Jie He, Shannon Frank, Allen C. Nunnally, Mark Bailey, Ann Jaskiw, Dana Feuchtbaum, Nathan C. Nussbaum, Amy P. Abernethy, Vincent A. Miller

    Publicat 2019
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  19. 19
    Lenalidomide promotes the development of <i>TP53</i>-mutated therapy-related myeloid neoplasms

    Lenalidomide promotes the development of <i>TP53</i>-mutated therapy-related myeloid neoplasms per Adam S. Sperling, Veronica Guerra, James A. Kennedy, Yuanqing Yan, Joanne I. Hsu, Feng Wang, Andrew Nguyen, Peter G. Miller, Marie McConkey, Vanessa A. Quevedo Barrios, Ken Furudate, Linda Zhang, Rashmi Kanagal‐Shamanna, Jianhua Zhang, Latasha Little, Curtis Gumbs, Naval Daver, Courtney D. DiNardo, Tapan M. Kadia, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia‐Manero, P. Andrew Futreal, Benjamin L. Ebert, Koichi Takahashi

    Publicat 2022
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  20. 20
    Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

    Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state per Peter G. Miller, Murugappan Sathappa, Jamie A. Moroco, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O. Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S. Sperling, Christopher J. Gibson, Josephine Kahn, Cyrus Y Jin, Matthew J. Ranaghan, Alisha Caliman, Merissa Brousseau, Eric S. Fischer, Robert Lintner, Federica Piccioni, Arthur J. Campbell, David E. Root, Colin W. Garvie, Benjamin L. Ebert

    Publicat 2022
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