Rezultati - Pekalski, Marcin L

Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells od Patel, Dipali, Rorbach, Joanna, Downes, Kate, Szukszto, Maciej J., Pekalski, Marcin L., Minczuk, Michal

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In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment od Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.

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Human IL-6R(hi)TIGIT(−) CD4(+) CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile od Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.

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Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing od Rainbow, Daniel B., Yang, Xin, Burren, Oliver, Pekalski, Marcin L., Smyth, Deborah J., Klarqvist, Marcus D. R., Penkett, Christopher J., Brugger, Kim, Martin, Howard, Todd, John A., Wallace, Chris, Wicker, Linda S.

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Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs od Gammage, Payam A., Gaude, Edoardo, Van Haute, Lindsey, Rebelo-Guiomar, Pedro, Jackson, Christopher B., Rorbach, Joanna, Pekalski, Marcin L., Robinson, Alan J., Charpentier, Marine, Concordet, Jean-Paul, Frezza, Christian, Minczuk, Michal

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IL-21 production by CD4(+) effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients od Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Cutler, Antony J., Dopico, Xaquin Castro, Smyth, Deborah J., Mashar, Meghavi, Schuilenburg, Helen, Walker, Neil M., Dunger, David B., Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.

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Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells od Bell, Charles J.M., Sun, Yongliang, Nowak, Urszula M., Clark, Jan, Howlett, Sarah, Pekalski, Marcin L., Yang, Xin, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Umana, Pablo, Klein, Christian, Hosse, Ralf J., Wicker, Linda S., Peterson, Laurence B.

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Widespread seasonal gene expression reveals annual differences in human immunity and physiology od Dopico, Xaquin Castro, Evangelou, Marina, Ferreira, Ricardo C., Guo, Hui, Pekalski, Marcin L., Smyth, Deborah J., Cooper, Nicholas, Burren, Oliver S., Fulford, Anthony J., Hennig, Branwen J., Prentice, Andrew M., Ziegler, Anette-G., Bonifacio, Ezio, Wallace, Chris, Todd, John A.

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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease od Peterson, Laurence B., Bell, Charles J.M., Howlett, Sarah K., Pekalski, Marcin L., Brady, Kevin, Hinton, Heather, Sauter, Denise, Todd, John A., Umana, Pablo, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Klein, Christian, Hosse, Ralf J., Wicker, Linda S.

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Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol od Ziegler, Anette-Gabriele, Arnolds, Stefanie, Kölln, Annika, Achenbach, Peter, Berner, Reinhard, Bonifacio, Ezio, Casteels, Kristina, Elding Larsson, Helena, Gündert, Melanie, Hasford, Joerg, Kordonouri, Olga, Lundgren, Markus, Oltarzewski, Mariusz, Pekalski, Marcin L, Pfirrmann, Markus, Snape, Matthew D, Szypowska, Agnieszka, Todd, John A

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Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial od Cutler, Antony J., Oliveira, Joao, Ferreira, Ricardo C., Challis, Ben, Walker, Neil M., Caddy, Sarah, Lu, Jia, Stevens, Helen E., Smyth, Deborah J., Pekalski, Marcin L., Kennet, Jane, Hunter, Kara M.D., Goodfellow, Ian, Wicker, Linda S., Todd, John A., Waldron-Lynch, Frank

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The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes od Seelig, Eleonora, Howlett, James, Porter, Linsey, Truman, Lucy, Heywood, James, Kennet, Jane, Arbon, Emma L., Anselmiova, Katerina, Walker, Neil M., Atkar, Ravinder, Pekalski, Marcin L., Rytina, Ed, Evans, Mark, Wicker, Linda S., Todd, John A., Mander, Adrian P., Bond, Simon, Waldron-Lynch, Frank

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Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping od Wallace, Chris, Cutler, Antony J, Pontikos, Nikolas, Pekalski, Marcin L, Burren, Oliver S, Cooper, Jason D, García, Arcadio Rubio, Ferreira, Ricardo C, Guo, Hui, Walker, Neil M, Smyth, Deborah J, Rich, Stephen S, Onengut-Gumuscu, Suna, Sawcer, Stephen J, Ban, Maria, Richardson, Sylvia, Todd, John A, Wicker, Linda S

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Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases od Ferreira, Ricardo C., Freitag, Daniel F., Cutler, Antony J., Howson, Joanna M. M., Rainbow, Daniel B., Smyth, Deborah J., Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M., Pekalski, Marcin L., Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S., Butterworth, Adam S., Malarstig, Anders, Danesh, John, Todd, John A.

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Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity od Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Rainbow, Daniel B., Yang, Xin, Cutler, Antony J., Oliveira, Joao, Castro Dopico, Xaquin, Smyth, Deborah J., Savinykh, Natalia, Mashar, Meghavi, Vyse, Tim J., Dunger, David B., Baxendale, Helen, Chandra, Anita, Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.

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Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp(620) Risk Allele Drive the Expansion of FOXP3(+) Regulatory T Cells and PD-1 Expression od Ferreira, Ricardo C., Castro Dopico, Xaquin, Oliveira, João J., Rainbow, Daniel B., Yang, Jennie H., Trzupek, Dominik, Todd, Sarah A., McNeill, Mhairi, Steri, Maristella, Orrù, Valeria, Fiorillo, Edoardo, Crouch, Daniel J. M., Pekalski, Marcin L., Cucca, Francesco, Tree, Tim I., Vyse, Tim J., Wicker, Linda S., Todd, John A.

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Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors od Pekalski, Marcin L, Ferreira, Ricardo C, Coulson, Richard M.R., Cutler, Antony J., Guo, Hui, Smyth, Deborah J., Downes, Kate, Dendrou, Calliope A., Dopico, Xaquin Castro, Esposito, Laura, Coleman, Gillian, Stevens, Helen E., Nutland, Sarah, Walker, Neil M., Guy, Catherine, Dunger, David B., Wallace, Chris, Tree, Timothy I. M., Todd, John A., Wicker, Linda S.

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A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes od Ferreira, Ricardo C., Guo, Hui, Coulson, Richard M.R., Smyth, Deborah J., Pekalski, Marcin L., Burren, Oliver S., Cutler, Antony J., Doecke, James D., Flint, Shaun, McKinney, Eoin F., Lyons, Paul A., Smith, Kenneth G.C., Achenbach, Peter, Beyerlein, Andreas, Dunger, David B., Clayton, David G., Wicker, Linda S., Todd, John A., Bonifacio, Ezio, Wallace, Chris, Ziegler, Anette-G.

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Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2 od Pekalski, Marcin L., García, Arcadio Rubio, Ferreira, Ricardo C., Rainbow, Daniel B., Smyth, Deborah J., Mashar, Meghavi, Brady, Jane, Savinykh, Natalia, Dopico, Xaquin Castro, Mahmood, Sumiyya, Duley, Simon, Stevens, Helen E., Walker, Neil M., Cutler, Antony J., Waldron-Lynch, Frank, Dunger, David B., Shannon-Lowe, Claire, Coles, Alasdair J., Jones, Joanne L., Wallace, Chris, Todd, John A., Wicker, Linda S.

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Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial od Todd, John A., Evangelou, Marina, Cutler, Antony J., Pekalski, Marcin L., Walker, Neil M., Stevens, Helen E., Porter, Linsey, Smyth, Deborah J., Rainbow, Daniel B., Ferreira, Ricardo C., Esposito, Laura, Hunter, Kara M. D., Loudon, Kevin, Irons, Kathryn, Yang, Jennie H., Bell, Charles J. M., Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L., Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I., Evans, Mark, Mander, Adrian P., Bond, Simon, Wicker, Linda S., Waldron-Lynch, Frank

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