检索结果 - Patrick McCarren

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  1. 1
    Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with <i>MTAP</i> Deletion

    Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with <i>MTAP</i> Deletion 由 Kevin M. Cottrell, Kimberly J. Briggs, Alice Tsai, Matthew R. Tonini, Douglas A. Whittington, Shanzhong Gong, Colin Liang, Patrick McCarren, Minjie Zhang, Wenhai Zhang, Alan Huang, John P. Maxwell

    出版 2025
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  2. 2
    Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

    Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties 由 Björn Over, Patrick McCarren, Per Artursson, Michael A. Foley, Fabrizio Giordanetto, Gunnar Grönberg, Constanze Hilgendorf, Maurice D. Lee, Pär Matsson, Giovanni Muncipinto, Mélanie Pellisson, Matthew W. D. Perry, Richard Svensson, Jeremy R. Duvall, Jan Kihlberg

    出版 2014
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  3. 3
    The Drug Repurposing Hub: a next-generation drug library and information resource

    The Drug Repurposing Hub: a next-generation drug library and information resource 由 Steven M. Corsello, Joshua A. Bittker, Zihan Liu, Joshua Gould, Patrick McCarren, Jodi Hirschman, Stephen Johnston, Anita Vrcic, Bang Wong, Mariya Khan, Jacob K. Asiedu, Rajiv Narayan, Christopher C. Mader, Aravind Subramanian, Todd R. Golub

    出版 2017
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  4. 4
    A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase

    A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase 由 Samantha Wellington, Partha P. Nag, K. Michalska, Stephen Johnston, R. Jedrzejczak, Virendar K. Kaushik, Anne E. Clatworthy, Noman Siddiqi, Patrick McCarren, Besnik Bajrami, N.I. Maltseva, Senya Combs, Stewart L. Fisher, A. Joachimiak, Stuart L. Schreiber, Deborah T. Hung

    出版 2017
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  5. 5
    Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers

    Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers 由 Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington, Haris Jahić, Janid A. Ali, Charles B. Davis, Shanzhong Gong, Deepali Gotur, Lina Gu, Patrick McCarren, Matthew R. Tonini, Alice Tsai, Erik Wilker, Hongling Yuan, Minjie Zhang, Wenhai Zhang, Alan Huang, John P. Maxwell

    出版 2024
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  6. 6
    An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

    An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8 由 David E. Olson, Namrata D. Udeshi, Noah A. Wolfson, Carol Ann Pitcairn, Eric D. Sullivan, Jacob D. Jaffe, Tanya Svinkina, Ted Natoli, Xiaodong Lü, Joshiawa Paulk, Patrick McCarren, Florence F. Wagner, Doug Barker, Eleanor Howe, Fanny Lazzaro, Jennifer Gale, Yan-Ling Zhang, Aravind Subramanian, Carol A. Fierke, Steven A. Carr, Edward B. Holson

    出版 2014
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  7. 7
    Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

    Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers 由 Florence F. Wagner, Yarong Zhang, Daniel M. Fass, Naima T. Joseph, Jennifer Gale, Michel Weïwer, Patrick McCarren, Stewart L. Fisher, Taner Kaya, Wen‐Ning Zhao, Surya A. Reis, Krista M. Hennig, Melvin E. Thomas, Bérénice C. Lemercier, Michael C. Lewis, Ji‐Song Guan, M. P. Moyer, Edward M. Scolnick, Stephen J. Haggarty, Li‐Huei Tsai, Edward B. Holson

    出版 2014
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  8. 8
    Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction

    Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction 由 David C. McKinney, Brian J. McMillan, Matthew J. Ranaghan, Jamie A. Moroco, Merissa Brousseau, Zachary Mullin-Bernstein, Meghan O’Keefe, Patrick McCarren, Michael F. Mesleh, Kathleen M. Mulvaney, Foxy P. Robinson, Ritu Singh, Besnik Bajrami, Florence F. Wagner, Robert Hilgraf, Martin J. Drysdale, Arthur J. Campbell, Adam Skepner, David E. Timm, Dale Porter, Virendar K. Kaushik, William R. Sellers, Alessandra Ianari

    出版 2021
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