Výsledky vyhledávání - Patrick McCarren
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1
Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with <i>MTAP</i> Deletion Autor Kevin M. Cottrell, Kimberly J. Briggs, Alice Tsai, Matthew R. Tonini, Douglas A. Whittington, Shanzhong Gong, Colin Liang, Patrick McCarren, Minjie Zhang, Wenhai Zhang, Alan Huang, John P. Maxwell
Vydáno 2025Artigo -
2
Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties Autor Björn Over, Patrick McCarren, Per Artursson, Michael A. Foley, Fabrizio Giordanetto, Gunnar Grönberg, Constanze Hilgendorf, Maurice D. Lee, Pär Matsson, Giovanni Muncipinto, Mélanie Pellisson, Matthew W. D. Perry, Richard Svensson, Jeremy R. Duvall, Jan Kihlberg
Vydáno 2014Artigo -
3
The Drug Repurposing Hub: a next-generation drug library and information resource Autor Steven M. Corsello, Joshua A. Bittker, Zihan Liu, Joshua Gould, Patrick McCarren, Jodi Hirschman, Stephen Johnston, Anita Vrcic, Bang Wong, Mariya Khan, Jacob K. Asiedu, Rajiv Narayan, Christopher C. Mader, Aravind Subramanian, Todd R. Golub
Vydáno 2017Carta -
4
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase Autor Samantha Wellington, Partha P. Nag, K. Michalska, Stephen Johnston, R. Jedrzejczak, Virendar K. Kaushik, Anne E. Clatworthy, Noman Siddiqi, Patrick McCarren, Besnik Bajrami, N.I. Maltseva, Senya Combs, Stewart L. Fisher, A. Joachimiak, Stuart L. Schreiber, Deborah T. Hung
Vydáno 2017Artigo -
5
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers Autor Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington, Haris Jahić, Janid A. Ali, Charles B. Davis, Shanzhong Gong, Deepali Gotur, Lina Gu, Patrick McCarren, Matthew R. Tonini, Alice Tsai, Erik Wilker, Hongling Yuan, Minjie Zhang, Wenhai Zhang, Alan Huang, John P. Maxwell
Vydáno 2024Artigo -
6
An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8 Autor David E. Olson, Namrata D. Udeshi, Noah A. Wolfson, Carol Ann Pitcairn, Eric D. Sullivan, Jacob D. Jaffe, Tanya Svinkina, Ted Natoli, Xiaodong Lü, Joshiawa Paulk, Patrick McCarren, Florence F. Wagner, Doug Barker, Eleanor Howe, Fanny Lazzaro, Jennifer Gale, Yan-Ling Zhang, Aravind Subramanian, Carol A. Fierke, Steven A. Carr, Edward B. Holson
Vydáno 2014Carta -
7
Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers Autor Florence F. Wagner, Yarong Zhang, Daniel M. Fass, Naima T. Joseph, Jennifer Gale, Michel Weïwer, Patrick McCarren, Stewart L. Fisher, Taner Kaya, Wen‐Ning Zhao, Surya A. Reis, Krista M. Hennig, Melvin E. Thomas, Bérénice C. Lemercier, Michael C. Lewis, Ji‐Song Guan, M. P. Moyer, Edward M. Scolnick, Stephen J. Haggarty, Li‐Huei Tsai, Edward B. Holson
Vydáno 2014Artigo -
8
Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction Autor David C. McKinney, Brian J. McMillan, Matthew J. Ranaghan, Jamie A. Moroco, Merissa Brousseau, Zachary Mullin-Bernstein, Meghan O’Keefe, Patrick McCarren, Michael F. Mesleh, Kathleen M. Mulvaney, Foxy P. Robinson, Ritu Singh, Besnik Bajrami, Florence F. Wagner, Robert Hilgraf, Martin J. Drysdale, Arthur J. Campbell, Adam Skepner, David E. Timm, Dale Porter, Virendar K. Kaushik, William R. Sellers, Alessandra Ianari
Vydáno 2021Artigo
Vyhledávací nástroje:
Související témata
Biochemistry
Biology
Chemistry
Gene
Pharmacology
Medicine
Cancer research
Chromatin
Computer science
Drug discovery
Enzyme
Histone
Histone deacetylase
Histone deacetylase 2
Neuroscience
Organic chemistry
Stereochemistry
ATP synthase
Acetylation
Allosteric regulation
Amino acid
Artificial intelligence
Bioinformatics
Blood–brain barrier
Bromodomain
Cell biology
Central nervous system
Chromatin remodeling
Class (philosophy)
Computational biology