Resultats de la cerca - Passini, Elisa

Human Atrial Cell Models to Analyse Haemodialysis-Related Effects on Cardiac Electrophysiology: Work in Progress per Passini, Elisa, Genovesi, Simonetta, Severi, Stefano

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Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach per Paci, Michelangelo, Passini, Elisa, Severi, Stefano, Hyttinen, Jari, Rodriguez, Blanca

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Simulation of the Effects of Extracellular Calcium Changes Leads to a Novel Computational Model of Human Ventricular Action Potential With a Revised Calcium Handling per Bartolucci, Chiara, Passini, Elisa, Hyttinen, Jari, Paci, Michelangelo, Severi, Stefano

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Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias per Passini, Elisa, Trovato, Cristian, Morissette, Pierre, Sannajust, Frederick, Bueno‐Orovio, Alfonso, Rodriguez, Blanca

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All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation per Paci, Michelangelo, Passini, Elisa, Klimas, Aleksandra, Severi, Stefano, Hyttinen, Jari, Rodriguez, Blanca, Entcheva, Emilia

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Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions per Paci, Michelangelo, Koivumäki, Jussi T., Lu, Hua Rong, Gallacher, David J., Passini, Elisa, Rodriguez, Blanca

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Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy per Passini, Elisa, Mincholé, Ana, Coppini, Raffaele, Cerbai, Elisabetta, Rodriguez, Blanca, Severi, Stefano, Bueno-Orovio, Alfonso

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Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities per Trovato, Cristian, Passini, Elisa, Nagy, Norbert, Varró, András, Abi-Gerges, Najah, Severi, Stefano, Rodriguez, Blanca

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Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment per Zhou, Xin, Qu, Yusheng, Passini, Elisa, Bueno-Orovio, Alfonso, Liu, Yang, Vargas, Hugo M., Rodriguez, Blanca

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Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies per Delaunois, Annie, Hebeisen, Simon, Gryshkova, Vitalina, Lushbough, Isabel, Passini, Elisa, Trovato, Cristian, Rodriguez, Blanca, Valentin, Jean-Pierre

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Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm per Muszkiewicz, Anna, Britton, Oliver J., Gemmell, Philip, Passini, Elisa, Sánchez, Carlos, Zhou, Xin, Carusi, Annamaria, Quinn, T. Alexander, Burrage, Kevin, Bueno-Orovio, Alfonso, Rodriguez, Blanca

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Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity per Passini, Elisa, Britton, Oliver J., Lu, Hua Rong, Rohrbacher, Jutta, Hermans, An N., Gallacher, David J., Greig, Robert J. H., Bueno-Orovio, Alfonso, Rodriguez, Blanca

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Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block per Tomek, Jakub, Bueno-Orovio, Alfonso, Passini, Elisa, Zhou, Xin, Minchole, Ana, Britton, Oliver, Bartolucci, Chiara, Severi, Stefano, Shrier, Alvin, Virag, Laszlo, Varro, Andras, Rodriguez, Blanca

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Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay per Morissette, Pierre, Polak, Sebastian, Chain, Anne, Zhai, Jin, Imredy, John P., Wildey, Mary Jo, Travis, Jeffrey, Fitzgerald, Kevin, Fanelli, Patrick, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick, Regan, Christopher

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Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19 per Delaunois, Annie, Abernathy, Matthew, Anderson, Warren D., Beattie, Kylie A., Chaudhary, Khuram W., Coulot, Julie, Gryshkova, Vitalina, Hebeisen, Simon, Holbrook, Mark, Kramer, James, Kuryshev, Yuri, Leishman, Derek, Lushbough, Isabel, Passini, Elisa, Redfern, Will S., Rodriguez, Blanca, Rossman, Eric I., Trovato, Cristian, Wu, Caiyun, Valentin, Jean‐Pierre

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Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop per Rodriguez, Blanca, Carusi, Annamaria, Abi-Gerges, Najah, Ariga, Rina, Britton, Oliver, Bub, Gil, Bueno-Orovio, Alfonso, Burton, Rebecca A.B., Carapella, Valentina, Cardone-Noott, Louie, Daniels, Matthew J., Davies, Mark R., Dutta, Sara, Ghetti, Andre, Grau, Vicente, Harmer, Stephen, Kopljar, Ivan, Lambiase, Pier, Lu, Hua Rong, Lyon, Aurore, Minchole, Ana, Muszkiewicz, Anna, Oster, Julien, Paci, Michelangelo, Passini, Elisa, Severi, Stefano, Taggart, Peter, Tinker, Andy, Valentin, Jean-Pierre, Varro, Andras, Wallman, Mikael, Zhou, Xin

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General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy per Li, Zhihua, Mirams, Gary R., Yoshinaga, Takashi, Ridder, Bradley J., Han, Xiaomei, Chen, Janell E., Stockbridge, Norman L., Wisialowski, Todd A., Damiano, Bruce, Severi, Stefano, Morissette, Pierre, Kowey, Peter R., Holbrook, Mark, Smith, Godfrey, Rasmusson, Randall L., Liu, Michael, Song, Zhen, Qu, Zhilin, Leishman, Derek J., Steidl‐Nichols, Jill, Rodriguez, Blanca, Bueno‐Orovio, Alfonso, Zhou, Xin, Passini, Elisa, Edwards, Andrew G., Morotti, Stefano, Ni, Haibo, Grandi, Eleonora, Clancy, Colleen E., Vandenberg, Jamie, Hill, Adam, Nakamura, Mikiko, Singer, Thomas, Polonchuk, Liudmila, Greiter‐Wilke, Andrea, Wang, Ken, Nave, Stephane, Fullerton, Aaron, Sobie, Eric A., Paci, Michelangelo, Musuamba Tshinanu, Flora, Strauss, David G.

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