Resultats de la cerca - Olena Barbash

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  1. 1
    Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability

    Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability per Laura Pontano, Priya Aggarwal, Olena Barbash, Eric J. Brown, Craig H. Bassing, J. Alan Diehl

    Publicat 2008
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  2. 2
    Mutations in Fbx4 Inhibit Dimerization of the SCFFbx4 Ligase and Contribute to Cyclin D1 Overexpression in Human Cancer

    Mutations in Fbx4 Inhibit Dimerization of the SCFFbx4 Ligase and Contribute to Cyclin D1 Overexpression in Human Cancer per Olena Barbash, Petia Zamfirova, Douglas I. Lin, Xiangmei Chen, Yang Ke, Hiroshi Nakagawa, Fengmin Lu, Anil K. Rustgi, J. Alan Diehl

    Publicat 2008
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  3. 3
    The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation

    The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation per Laura Pontano Vaites, Eric K. Lee, Zhaorui Lian, Olena Barbash, Darshan Roy, Mariusz A. Wasik, Andres J. Klein‐Szanto, Anil K. Rustgi, J. Alan Diehl

    Publicat 2011
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  4. 4
    Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

    Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex per Douglas I. Lin, Olena Barbash, Suresh Kumar, Jason D. Weber, J. Wade Harper, Andres J. Klein–Szanto, Anil K. Rustgi, Serge Y. Fuchs, J. Alan Diehl

    Publicat 2006
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  5. 5
    “Z4” Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism

    “Z4” Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism per Hitoshi Shiota, Janine E. Elya, Artyom A. Alekseyenko, Pauline M. Chou, Shelby Gorman, Olena Barbash, Kelly Becht, Kristina Danga, Mitzi I. Kuroda, Valentina Nardi, Christopher A. French

    Publicat 2018
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  6. 6
    Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

    Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer per Anastasia Wyce, Yan Degenhardt, Yuchen Bai, BaoChau Le, Susan Korenchuk, Ming-Chih Crouthamel, Charles F. McHugh, Robert L. Vessella, Caretha L. Creasy, Peter J. Tummino, Olena Barbash

    Publicat 2013
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  7. 7
    Phase I/II study of the clinical activity and safety of GSK3326595 in patients with myeloid neoplasms

    Phase I/II study of the clinical activity and safety of GSK3326595 in patients with myeloid neoplasms per Justin M. Watts, Mark D. Minden, Kimo Bachiashvili, Andrew M. Brunner, Sameem Abedin, Timothy Crossman, Magdalena Zając, V. V. Moroz, Jacqueline L. Egger, Aarti Tarkar, Brandon E. Kremer, Olena Barbash, Gautam Borthakur

    Publicat 2024
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  8. 8
    PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

    PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression per Kelly Chiang, Agnieszka Zielińska, Abeer M. Shaaban, María Pilar Sánchez-Bailón, James Jarrold, Thomas L. Clarke, Jingxian Zhang, Adele Francis, J. Louise Jones, Sally Smith, Olena Barbash, Ernesto Guccione, Gillian Farnie, Matthew J. Smalley, Clare C. Davies

    Publicat 2017
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  9. 9
    Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

    Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation per Glenn S. Van Aller, Nicolas Reynoird, Olena Barbash, Michael J. Huddleston, Shichong Liu, Anne‐Flore Zmoos, Patrick McDevitt, Robert H. Sinnamon, BaoChau Le, Glòria Mas Martín, Roland S. Annan, Julien Sage, Benjamin A. Garcia, Peter J. Tummino, Or Gozani, Ryan G. Kruger

    Publicat 2012
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  10. 10
    SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

    SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer per Paweł K. Mazur, Nicolas Reynoird, Purvesh Khatri, Pascal W.T.C. Jansen, Alex W. Wilkinson, Shichong Liu, Olena Barbash, Glenn S. Van Aller, Michael J. Huddleston, Dashyant Dhanak, Peter J. Tummino, Ryan G. Kruger, Benjamin A. Garcia, Atul J. Butte, Michiel Vermeulen, Julien Sage, Or Gozani

    Publicat 2014
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  11. 11
    Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

    Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing per Sarah V. Gerhart, Wendy A. Kellner, Christine Thompson, Melissa B. Pappalardi, Xiping Zhang, Rocío Montes de, Elayne Penebre, Kenneth W. Duncan, Ann Boriack-Sjodin, BaoChau Le, Christina R. Majer, Michael T. McCabe, Chris Carpenter, Neil Johnson, Ryan G. Kruger, Olena Barbash

    Publicat 2018
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  12. 12
    Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses

    Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses per Andrew Fedoriw, Leilei Shi, Shane W. O’Brien, Kimberly N. Smitheman, Yunfei Wang, Jiakai Hou, Christian Sherk, Satyajit Rajapurkar, Jenny Laraio, Leila J. Williams, Chunyu Xu, Guangchun Han, Qin Feng, Mark T. Bedford, Linghua Wang, Olena Barbash, Ryan G. Kruger, Patrick Hwu, Helai P. Mohammad, Weiyi Peng

    Publicat 2022
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  13. 13
    BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

    BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models per Anastasia Wyce, Gopinath Ganji, Kimberly N. Smitheman, Chun‐wa Chung, Susan Korenchuk, Yuchen Bai, Olena Barbash, BaoChau Le, Peter D. Craggs, Michael T. McCabe, Karen M. Kennedy-Wilson, Lydia V. Sanchez, Romain Gosmini, Nigel J. Parr, Charles F. McHugh, Dashyant Dhanak, Rab K. Prinjha, Kurt R. Auger, Peter J. Tummino

    Publicat 2013
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  14. 14
    Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

    Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762 per Aristeidis Chaidos, Valentina S. Caputo, Katerina Gouvedenou, Binbin Liu, Ilaria Marigo, Mohammed S. Chaudhry, Antonia Rotolo, David F. Tough, Nicholas Smithers, Anna K. Bassil, Trevor Chapman, Nicola Harker, Olena Barbash, Peter J. Tummino, Niam Al-Mahdi, Andrea Haynes, Leanne Cutler, BaoChau Le, Amin Rahemtulla, Irene Roberts, Maurits F. Kleijnen, Jason Witherington, Nigel J. Parr, Rab K. Prinjha, Anastasios Karadimitris

    Publicat 2013
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  15. 15
    Homologous Recombination Deficiency: Concepts, Definitions, and Assays

    Homologous Recombination Deficiency: Concepts, Definitions, and Assays per Mark Stewart, Diana Merino Vega, Rebecca C. Arend, Jonathan Baden, Olena Barbash, Nike Beaubier, Grace Collins, Tim French, Negar Ghahramani, Patsy Hinson, Petar Jelinic, Matthew J. Marton, Kimberly McGregor, Jerod Parsons, Lakshman Ramamurthy, Mark Sausen, Ethan S. Sokol, Albrecht Stenzinger, Hillary Stires, Kirsten M. Timms, Diana Turco, Iris Wang, J Andrew Williams, Elaine Wong-Ho, Jeff Allen

    Publicat 2022
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  16. 16
    Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors

    Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors per Sarina A. Piha‐Paul, Christine L. Hann, Christopher A. French, Sophie Cousin, Irene Braña, Phillippe Cassier, Víctor Moreno, Johann S. de Bono, Sara Harward, Geraldine Ferron‐Brady, Olena Barbash, Anastasia Wyce, Yuehui Wu, Thierry Horner, Meg Annan, Nigel J. Parr, Rabinder Prinjha, Christopher L. Carpenter, John Hilton, David S. Hong, Naomi B. Haas, Mark C. Markowski, Arindam Dhar, Peter J. O’Dwyer, Geoffrey I. Shapiro

    Publicat 2019
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  17. 17
    Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

    Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation per Jia Yi Fong, Luca Pignata, Pierre-Alexis Goy, Kimihito C. Kawabata, Stanley Chun-Wei Lee, Cheryl M. Koh, Daniele Musiani, Enrico Massignani, Andriana G. Kotini, Alex Penson, Cheng Mun Wun, Yudao Shen, Megan Schwarz, Diana Low, Alexander Rialdi, Michelle Ki, Heike Wollmann, Slim Mzoughi, Florence Gay, Christine Thompson, Timothy K. Hart, Olena Barbash, Genna M. Luciani, Magdalena M. Szewczyk, Bas J. Wouters, Ruud Delwel, Eirini P. Papapetrou, Dalia Baršytė-Lovejoy, C.H. Arrowsmith, Mark D. Minden, Jian Jin, Ari Melnick, Tiziana Bonaldi, Omar Abdel‐Wahab, Ernesto Guccione

    Publicat 2019
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  18. 18
    Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

    Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia per Charles C. Bell, Katie Fennell, Yih-Chih Chan, Florian Rambow, Miriam M. Yeung, Dane Vassiliadis, Luis E. Lara Gonzalez, Paul Yeh, Luciano G. Martelotto, Aljosja Rogiers, Brandon E. Kremer, Olena Barbash, Helai P. Mohammad, Timothy M. Johanson, Marian L. Burr, Arindam Dhar, Natalie O. Karpinich, Luyi Tian, Dean Tyler, Laura MacPherson, Junwei Shi, Nathan Pinnawala, Chun Yew Fong, Anthony T. Papenfuss, Sean M. Grimmond, Sarah‐Jane Dawson, Rhys S. Allan, Ryan G. Kruger, Christopher R. Vakoc, David L. Goode, Shalin H. Naik, Omer Gilan, Enid Y.N. Lam, Jean‐Christophe Marine, Rab K. Prinjha, Mark A. Dawson

    Publicat 2019
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  19. 19
    Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

    Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss per Andrew Fedoriw, Satyajit Rajapurkar, Shane W. O’Brien, Sarah V. Gerhart, Lorna H. Mitchell, Nicholas D. Adams, Nathalie Rioux, Trupti Lingaraj, Scott Ribich, Melissa B. Pappalardi, Niyant Shah, Jenny Laraio, Yan Liu, Michael Butticello, Chris Carpenter, Caretha L. Creasy, Susan Korenchuk, Michael T. McCabe, Charles F. McHugh, Raman P. Nagarajan, Craig D. Wagner, Francesca Zappacosta, Roland S. Annan, N.O. Concha, Roberta Thomas, Timothy K. Hart, J. Joshua Smith, Robert A. Copeland, Mikel P. Moyer, John Campbell, Kim Stickland, James E. Mills, Suzanne Jacques-O’Hagan, Christina J. Allain, Danielle Johnston, Alejandra Raimondi, Margaret Porter Scott, Nigel J. Waters, Kerren K. Swinger, Ann Boriack-Sjodin, Thomas V. Riera, Gideon Shapiro, Richard Chesworth, Rabinder Prinjha, Ryan G. Kruger, Olena Barbash, Helai P. Mohammad

    Publicat 2019
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