Resultados da busca - Nicholas McHugh

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  1. 1
    Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo

    Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo por Annabelle Biscans, Socheata Ly, Nicholas McHugh, David Cooper, Anastasia Khvorova

    Publicado em 2022
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  2. 2
    Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

    Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles por Annabelle Biscans, Jillian Caiazzi, Nicholas McHugh, Vignesh Hariharan, Manish Muhuri, Anastasia Khvorova

    Publicado em 2020
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  3. 3
    The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

    The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy por Annabelle Biscans, Jillian Caiazzi, Sarah M. Davis, Nicholas McHugh, Jacquelyn Sousa, Anastasia Khvorova

    Publicado em 2020
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  4. 4
    Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

    Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 por Sarah M. Davis, Vignesh Hariharan, Agnes S. Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova

    Publicado em 2022
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  5. 5
    Silencing <i>Apoe</i> with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

    Silencing <i>Apoe</i> with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease por Chantal Ferguson, Samuel Hildebrand, Bruno M.D.C. Godinho, Julianna Buchwald, Dimas Echeverria, Andrew H. Coles, Anastasia P. Grigorenko, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Matthew Hassler, Francesco Santarelli, Michael T. Heneka, Е. И. Рогаев, Anastasia Khvorova

    Publicado em 2024
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  6. 6
    An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

    An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis por Batuhan Yenilmez, Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz, Julia F. Alterman, Matthew Hassler, Samuel Hildebrand, Chloe DiMarzio, Nicholas McHugh, Lorenc Vangjeli, Jacquelyn Sousa, Meixia Pan, Xianlin Han, Michael A. Brehm, Anastasia Khvorova, Michael Czech

    Publicado em 2021
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  7. 7
    Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

    Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin por Qi Tang, Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel Hildebrand, Khashayar Afshari, Katherine Y. Gross, Jacquelyn Sousa, Allison Maebius, Christina Bartholdy, Pia Pernille Søgaard, Malene Jackerott, Vignesh Hariharan, Ashley Summers, Xueli Fan, Ken Okamura, Kathryn Monopoli, David Cooper, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, Raymond Furgal, Karen Dresser, Sarah J. Winter, Annabelle Biscans, Jane Chuprin, Nazgol‐Sadat Haddadi, Shany Sherman, Ümmügülsüm Yıldız-Altay, Mehdi Rashighi, Jillian M. Richmond, Claire Bouix‐Peter, Carine Blanchard, Adam Clauss, Julia F. Alterman, Anastasia Khvorova, John E. Harris

    Publicado em 2023
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  8. 8
    Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

    Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection por Vignesh Hariharan, Minwook Shin, Ching‐Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada, Zhiru Guo, Mohan Somasundaran, Qi Tang, Kathryn Monopoli, Pranathi M. Krishnamurthy, Gitali Devi, Nicholas McHugh, David Cooper, Dimas Echeverria, John Cruz, Io Long Chan, Ping Liu, Sun-Young Lim, Jill McConnell, Satya Prakash Singh, Samuel Hildebrand, Jacquelyn Sousa, Sarah M. Davis, Zachary Kennedy, Chantal Ferguson, Bruno M.D.C. Godinho, Yann Thillier, Jillian Caiazzi, Socheata Ly, Manish Muhuri, Karen Kelly, Fiachra Humphries, Alyssa Cousineau, Krishna Mohan Parsi, Qi Li, Yang Wang, René Maehr, Guangping Gao, Dmitry Korkin, William M. McDougall, Robert W. Finberg, Katherine A. Fitzgerald, Jennifer Wang, Jonathan K. Watts, Anastasia Khvorova

    Publicado em 2023
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