نتائج البحث - Nicholas Kwiatkowski
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Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors حسب Sampada Kalan, Ramon Amat, Miriam Merzel Schachter, Nicholas Kwiatkowski, Brian J. Abraham, Yanke Liang, Tinghu Zhang, Calla M. Olson, Stéphane Larochelle, Richard A. Young, Nathanael S. Gray, Robert P. Fisher
منشور في 2017Artigo -
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Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML حسب Matthias Brand, Baishan Jiang, Sophie Bauer, Katherine A. Donovan, Yanke Liang, Eric S. Wang, Radosław P. Nowak, Jingting Yuan, Tinghu Zhang, Nicholas Kwiatkowski, André C. Müller, Eric S. Fischer, Nathanael S. Gray, Georg Winter
منشور في 2018Artigo -
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High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors حسب Chandrasekhar V. Miduturu, Xianming Deng, Nicholas Kwiatkowski, Wannian Yang, Laurent Brault, P. Filippakopoulos, Eunah Chung, Qingkai Yang, Juerg Schwaller, Stefan Knapp, Randall W. King, Jiing‐Dwan Lee, Sanna Herrgård, Patrick P. Zarrinkar, Nathanael S. Gray
منشور في 2011Artigo -
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Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors حسب Yang Gao, Tinghu Zhang, Hideki Terai, Scott B. Ficarro, Nicholas Kwiatkowski, Ming-Feng Hao, Bandana Sharma, Camilla L. Christensen, Edmond Chipumuro, Kwok‐Kin Wong, Jarrod A. Marto, Peter S. Hammerman, Nathanael S. Gray, Rani E. George
منشور في 2017Artigo -
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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function حسب Nicholas Kwiatkowski, Nannette Jelluma, P. Filippakopoulos, M. Soundararajan, Michael S. Manak, Mijung Kwon, Hwan Geun Choi, Taebo Sim, Quinn L. Deveraux, Sabine Rottmann, David Pellman, Jagesh V. Shah, Geert J.P.L. Kops, Stefan Knapp, Nathanael S. Gray
منشور في 2010Artigo -
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High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma حسب Philip Eliades, Brian J. Abraham, Zhenyu Ji, David M. Miller, Camilla L. Christensen, Nicholas Kwiatkowski, Raj Kumar, Ching Ni Njauw, Michael Taylor, Benchun Miao, Tinghu Zhang, Kwok‐Kin Wong, Nathanael S. Gray, Richard A. Young, Hensin Tsao
منشور في 2018Artigo -
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Discovery and resistance mechanism of a selective CDK12 degrader حسب Baishan Jiang, Yang Gao, Jianwei Che, Wenchao Lu, Ines H. Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J. Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M. Riching, Danette L. Daniels, Peter K. Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S. Gray
منشور في 2021Artigo -
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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer حسب Yubao Wang, Tinghu Zhang, Nicholas Kwiatkowski, Brian J. Abraham, Tong Ihn Lee, Shaozhen Xie, Haluk Yuzugullu, Thanh Von, Heyuan Li, Ziao Lin, Daniel G. Stover, Elgene Lim, Zhigang C. Wang, J. Dirk Iglehart, Richard A. Young, Nathanael S. Gray, Jean J. Zhao
منشور في 2015Artigo -
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Small genomic insertions form enhancers that misregulate oncogenes حسب Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert‐Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
منشور في 2017Artigo -
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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation حسب Calla M. Olson, Baishan Jiang, Michael A. Erb, Yanke Liang, Zainab M. Doctor, Zinan Zhang, Tinghu Zhang, Nicholas Kwiatkowski, Myriam Boukhali, Jennifer L. Green, Wilhelm Haas, Tyzoon Nomanbhoy, Eric S. Fischer, Richard A. Young, James E. Bradner, Georg Winter, Nathanael S. Gray
منشور في 2017Artigo -
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CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer حسب Edmond Chipumuro, Eugenio Marco, Camilla L. Christensen, Nicholas Kwiatkowski, Tinghu Zhang, Clark M. Hatheway, Brian J. Abraham, Bandana Sharma, Caleb M. Yeung, Abigail Altabef, Antonio R. Pérez‐Atayde, Kwok‐Kin Wong, Guo‐Cheng Yuan, Nathanael S. Gray, Richard A. Young, Rani E. George
منشور في 2014Artigo -
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THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors حسب Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rossella Marullo, M. Nieves Calvo-Vidal, Jude M. Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Román, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti
منشور في 2017Artigo -
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EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma حسب Amanda Balboni Iniguez, Björn Stolte, Emily Jue Wang, Amy Saur Conway, Gabriela Alexe, Neekesh V. Dharia, Nicholas Kwiatkowski, Tinghu Zhang, Brian J. Abraham, Jaume Mora, Peter Kalev, Alan L. Leggett, Dipanjan Chowdhury, Cyril H. Benes, Richard A. Young, Nathanael S. Gray, Kimberly Stegmaier
منشور في 2018Artigo -
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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands حسب Lara Gechijian, Dennis L. Buckley, Matthew A. Lawlor, Jaime M. Reyes, Joshiawa Paulk, Christopher J. Ott, Georg Winter, Michael A. Erb, Thomas G. Scott, Mousheng Xu, Hyuk‐Soo Seo, Sirano Dhe‐Paganon, Nicholas Kwiatkowski, Jennifer A. Perry, Jun Qi, Nathanael S. Gray, James E. Bradner
منشور في 2018Artigo -
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A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer حسب Jieun Son, Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa L. Verano, Mika Lin, John M. Hatcher, Nicholas Kwiatkowski, Pınar Ö. Eser, Michael J. Poitras, Stephen Wang, Man Xu, Prafulla C. Gokhale, Michael D. Cameron, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne
منشور في 2022Artigo
أدوات البحث:
موضوعات ذات صلة
Biology
Cancer research
Genetics
Gene
Cell biology
Chemistry
Biochemistry
Kinase
Computational biology
Cell cycle
Transcription factor
Cancer
Medicine
Cyclin-dependent kinase 2
Cell
Cyclin-dependent kinase
Cyclin-dependent kinase 7
Signal transduction
Enhancer
Linguistics
Philosophy
Protein kinase A
Transcription (linguistics)
Apoptosis
DNA
Gene expression
Internal medicine
Pharmacology
DNA damage
Immunology