檢索結果 - Nicholas Kwiatkowski

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  1. 1
    Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8

    Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 由 John M. Hatcher, Eric S. Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim, Nathanael S. Gray

    出版 2018
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  2. 2
    Release of Mps1 from kinetochores is crucial for timely anaphase onset

    Release of Mps1 from kinetochores is crucial for timely anaphase onset 由 Nannette Jelluma, Tobias B. Dansen, Tale Sliedrecht, Nicholas Kwiatkowski, Geert J.P.L. Kops

    出版 2010
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  3. 3
    Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines

    Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines 由 Antonio Calles, Nicholas Kwiatkowski, Bernard K. Cammarata, Dalia Ercan, Nathanael S. Gray, Pasi A. Jänne

    出版 2014
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  4. 4
    Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1

    Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1 由 Xianming Deng, Qingkai Yang, Nicholas Kwiatkowski, Taebo Sim, Ultan McDermott, Jeffrey Settleman, Jiing-Dwan Lee, Nathanael S. Gray

    出版 2011
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  5. 5
    Development of CDK2 and CDK5 Dual Degrader TMX‐2172

    Development of CDK2 and CDK5 Dual Degrader TMX‐2172 由 Mingxing Teng, Jie Jiang, Zhixiang He, Nicholas Kwiatkowski, Katherine A. Donovan, Caitlin E. Mills, Chiara Victor, John M. Hatcher, Eric S. Fischer, Peter K. Sorger, Tinghu Zhang, Nathanael S. Gray

    出版 2020
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  6. 6
    Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors

    Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors 由 Sampada Kalan, Ramon Amat, Miriam Merzel Schachter, Nicholas Kwiatkowski, Brian J. Abraham, Yanke Liang, Tinghu Zhang, Calla M. Olson, Stéphane Larochelle, Richard A. Young, Nathanael S. Gray, Robert P. Fisher

    出版 2017
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  7. 7
    Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML

    Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML 由 Matthias Brand, Baishan Jiang, Sophie Bauer, Katherine A. Donovan, Yanke Liang, Eric S. Wang, Radosław P. Nowak, Jingting Yuan, Tinghu Zhang, Nicholas Kwiatkowski, André C. Müller, Eric S. Fischer, Nathanael S. Gray, Georg Winter

    出版 2018
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  8. 8
    High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors

    High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors 由 Chandrasekhar V. Miduturu, Xianming Deng, Nicholas Kwiatkowski, Wannian Yang, Laurent Brault, P. Filippakopoulos, Eunah Chung, Qingkai Yang, Juerg Schwaller, Stefan Knapp, Randall W. King, Jiing‐Dwan Lee, Sanna Herrgård, Patrick P. Zarrinkar, Nathanael S. Gray

    出版 2011
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  9. 9
    Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

    Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors 由 Yang Gao, Tinghu Zhang, Hideki Terai, Scott B. Ficarro, Nicholas Kwiatkowski, Ming-Feng Hao, Bandana Sharma, Camilla L. Christensen, Edmond Chipumuro, Kwok‐Kin Wong, Jarrod A. Marto, Peter S. Hammerman, Nathanael S. Gray, Rani E. George

    出版 2017
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  10. 10
    Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

    Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function 由 Nicholas Kwiatkowski, Nannette Jelluma, P. Filippakopoulos, M. Soundararajan, Michael S. Manak, Mijung Kwon, Hwan Geun Choi, Taebo Sim, Quinn L. Deveraux, Sabine Rottmann, David Pellman, Jagesh V. Shah, Geert J.P.L. Kops, Stefan Knapp, Nathanael S. Gray

    出版 2010
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  11. 11
    High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

    High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma 由 Philip Eliades, Brian J. Abraham, Zhenyu Ji, David M. Miller, Camilla L. Christensen, Nicholas Kwiatkowski, Raj Kumar, Ching Ni Njauw, Michael Taylor, Benchun Miao, Tinghu Zhang, Kwok‐Kin Wong, Nathanael S. Gray, Richard A. Young, Hensin Tsao

    出版 2018
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  12. 12
    Discovery and resistance mechanism of a selective CDK12 degrader

    Discovery and resistance mechanism of a selective CDK12 degrader 由 Baishan Jiang, Yang Gao, Jianwei Che, Wenchao Lu, Ines H. Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J. Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M. Riching, Danette L. Daniels, Peter K. Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S. Gray

    出版 2021
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  13. 13
    CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

    CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer 由 Yubao Wang, Tinghu Zhang, Nicholas Kwiatkowski, Brian J. Abraham, Tong Ihn Lee, Shaozhen Xie, Haluk Yuzugullu, Thanh Von, Heyuan Li, Ziao Lin, Daniel G. Stover, Elgene Lim, Zhigang C. Wang, J. Dirk Iglehart, Richard A. Young, Nathanael S. Gray, Jean J. Zhao

    出版 2015
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  14. 14
    Small genomic insertions form enhancers that misregulate oncogenes

    Small genomic insertions form enhancers that misregulate oncogenes 由 Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert‐Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young

    出版 2017
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  15. 15
    Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

    Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation 由 Calla M. Olson, Baishan Jiang, Michael A. Erb, Yanke Liang, Zainab M. Doctor, Zinan Zhang, Tinghu Zhang, Nicholas Kwiatkowski, Myriam Boukhali, Jennifer L. Green, Wilhelm Haas, Tyzoon Nomanbhoy, Eric S. Fischer, Richard A. Young, James E. Bradner, Georg Winter, Nathanael S. Gray

    出版 2017
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  16. 16
    CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

    CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer 由 Edmond Chipumuro, Eugenio Marco, Camilla L. Christensen, Nicholas Kwiatkowski, Tinghu Zhang, Clark M. Hatheway, Brian J. Abraham, Bandana Sharma, Caleb M. Yeung, Abigail Altabef, Antonio R. Pérez‐Atayde, Kwok‐Kin Wong, Guo‐Cheng Yuan, Nathanael S. Gray, Richard A. Young, Rani E. George

    出版 2014
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  17. 17
    THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

    THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors 由 Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rossella Marullo, M. Nieves Calvo-Vidal, Jude M. Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Román, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti

    出版 2017
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  18. 18
    EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

    EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma 由 Amanda Balboni Iniguez, Björn Stolte, Emily Jue Wang, Amy Saur Conway, Gabriela Alexe, Neekesh V. Dharia, Nicholas Kwiatkowski, Tinghu Zhang, Brian J. Abraham, Jaume Mora, Peter Kalev, Alan L. Leggett, Dipanjan Chowdhury, Cyril H. Benes, Richard A. Young, Nathanael S. Gray, Kimberly Stegmaier

    出版 2018
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  19. 19
    Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

    Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands 由 Lara Gechijian, Dennis L. Buckley, Matthew A. Lawlor, Jaime M. Reyes, Joshiawa Paulk, Christopher J. Ott, Georg Winter, Michael A. Erb, Thomas G. Scott, Mousheng Xu, Hyuk‐Soo Seo, Sirano Dhe‐Paganon, Nicholas Kwiatkowski, Jennifer A. Perry, Jun Qi, Nathanael S. Gray, James E. Bradner

    出版 2018
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  20. 20
    A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer

    A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer 由 Jieun Son, Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa L. Verano, Mika Lin, John M. Hatcher, Nicholas Kwiatkowski, Pınar Ö. Eser, Michael J. Poitras, Stephen Wang, Man Xu, Prafulla C. Gokhale, Michael D. Cameron, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne

    出版 2022
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